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Galnt6 polypeptide N-acetylgalactosaminyltransferase 6 [ Mus musculus (house mouse) ]

Gene ID: 207839, updated on 2-Nov-2024

Summary

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Official Symbol
Galnt6provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 6provided by MGI
Primary source
MGI:MGI:1891640
See related
Ensembl:ENSMUSG00000037280 AllianceGenome:MGI:1891640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GalNAc-T6; 4632410F13
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via threonine. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Is expressed in exocrine system; paravertebral ganglion; and skeleton. Orthologous to human GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 18.2), small intestine adult (RPKM 15.4) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Galnt6 in Genome Data Viewer
Location:
15 F1; 15 56.39 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100587796..100627257, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100689915..100729376, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene bridging integrator 2 Neighboring gene microRNA 6961 Neighboring gene STARR-positive B cell enhancer ABC_E311 Neighboring gene chymotrypsin-like elastase family, member 1 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E10882 Neighboring gene RIKEN cDNA I730030J21 gene Neighboring gene STARR-positive B cell enhancer ABC_E5518 Neighboring gene STARR-positive B cell enhancer ABC_E2451 Neighboring gene predicted gene, 52175 Neighboring gene solute carrier family 4 (anion exchanger), member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. Bennett EP, et al. J Biol Chem, 1999 Sep 3. PMID 10464263
  2. Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. Yoshida CA, et al. J Biol Chem, 2014 Sep 19. PMID 25107907, Free PMC Article
  3. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
  4. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
  5. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This paper describes the identification and cloning of the orthologous human enzyme of mouse UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6.
    Title: Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via threonine ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 6
Names
N-acetylgalactosaminyltransferase T-6
Protein-UDP acetylgalactosaminyltransferase 6
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6
polypeptide GalNAc transferase 6
pp-GaNTase 6
NP_001155239.1
NP_001155240.1
NP_766039.2
XP_030104297.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161767.1 → NP_001155239.1  polypeptide N-acetylgalactosaminyltransferase 6

    See identical proteins and their annotated locations for NP_001155239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC123724, AK159721, BQ175003, BY196827
    Consensus CDS
    CCDS27843.1
    UniProtKB/Swiss-Prot
    Q0VE84, Q3TWF0, Q8C7U7, Q8CED2, Q9QZ16
    Related
    ENSMUSP00000056705.6, ENSMUST00000052069.12
    Conserved Domains (2) summary
    cd02510
    Location:180 → 485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497 → 619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_001161768.1 → NP_001155240.1  polypeptide N-acetylgalactosaminyltransferase 6

    See identical proteins and their annotated locations for NP_001155240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC123724, AK049222, BQ175003
    Consensus CDS
    CCDS27843.1
    UniProtKB/Swiss-Prot
    Q0VE84, Q3TWF0, Q8C7U7, Q8CED2, Q9QZ16
    Related
    ENSMUSP00000124793.2, ENSMUST00000161514.2
    Conserved Domains (2) summary
    cd02510
    Location:180 → 485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497 → 619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. NM_172451.3 → NP_766039.2  polypeptide N-acetylgalactosaminyltransferase 6

    See identical proteins and their annotated locations for NP_766039.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC123724, AK028506, AK159721, BQ175003
    Consensus CDS
    CCDS27843.1
    UniProtKB/Swiss-Prot
    Q0VE84, Q3TWF0, Q8C7U7, Q8CED2, Q9QZ16
    Related
    ENSMUSP00000123848.2, ENSMUST00000159715.8
    Conserved Domains (2) summary
    cd02510
    Location:180 → 485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497 → 619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100587796..100627257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248437.2 → XP_030104297.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    UniProtKB/Swiss-Prot
    Q0VE84, Q3TWF0, Q8C7U7, Q8CED2, Q9QZ16
    Conserved Domains (2) summary
    cd02510
    Location:180 → 485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497 → 619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C7U7.1 GenPept UniProtKB/Swiss-Prot:Q8C7U7

Gene LinkOut

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