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Alg1 ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase [ Mus musculus (house mouse) ]

Gene ID: 208211, updated on 2-Nov-2024

Summary

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Official Symbol
Alg1provided by MGI
Official Full Name
ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferaseprovided by MGI
Primary source
MGI:MGI:2384774
See related
Ensembl:ENSMUSG00000039427 AllianceGenome:MGI:2384774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HMT1; HMAT1
Summary
Predicted to enable chitobiosyldiphosphodolichol beta-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of with a positive effect on protein N-linked glycosylation. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 34.2), ovary adult (RPKM 29.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Alg1 in Genome Data Viewer
Location:
16 A1; 16 2.51 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (5051410..5062773)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5233621..5244909)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Neighboring gene expressed sequence AU021092 Neighboring gene STARR-positive B cell enhancer mm9_chr16:5233472-5233773 Neighboring gene microRNA 6364 Neighboring gene eukaryotic elongation factor 2 lysine methyltransferase Neighboring gene predicted gene 15983 Neighboring gene predicted gene, 57635 Neighboring gene predicted gene, 41414

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC18946

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chitobiosyldiphosphodolichol beta-mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables chitobiosyldiphosphodolichol beta-mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_positive_effect protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic side of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
chitobiosyldiphosphodolichol beta-mannosyltransferase
Names
GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase
GDP-mannose-dolichol diphosphochitobiose mannosyltransferase
asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)
asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase)
asparagine-linked glycosylation protein 1 homolog
beta-1,4 mannosyltransferase
NP_663337.2
XP_011244162.1
XP_036015739.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145362.2 → NP_663337.2  chitobiosyldiphosphodolichol beta-mannosyltransferase

    See identical proteins and their annotated locations for NP_663337.2

    Status: VALIDATED

    Source sequence(s)
    AK145871, BE948597
    Consensus CDS
    CCDS49753.1
    UniProtKB/Swiss-Prot
    Q3UKT8, Q921Q3
    Related
    ENSMUSP00000097770.3, ENSMUST00000100196.9
    Conserved Domains (2) summary
    cd03816
    Location:33 → 461
    GT1_ALG1_like; This family is most closely related to the GT1 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and ...
    PLN02275
    Location:29 → 424
    PLN02275; transferase, transferring glycosyl groups

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    5051410..5062773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159846.1 → XP_036015739.1  chitobiosyldiphosphodolichol beta-mannosyltransferase isoform X1

    Conserved Domains (1) summary
    cd03816
    Location:33 → 515
    GT33_ALG1-like; chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins

  2. XM_011245860.3 → XP_011244162.1  chitobiosyldiphosphodolichol beta-mannosyltransferase isoform X2

    Conserved Domains (1) summary
    cl10013
    Location:24 → 306
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

RNA

  1. XR_004939176.1 RNA Sequence

  2. XR_004939175.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921Q3.3 GenPept UniProtKB/Swiss-Prot:Q921Q3

Gene LinkOut

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