Stat2 signal transducer and activator of transcription 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stat2provided by MGI
Official Full Name: signal transducer and activator of transcription 2provided by MGI
Primary source: MGI:MGI:103039
See related: Ensembl:ENSMUSG00000040033 AllianceGenome:MGI:103039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1600010G07Rik
Summary: Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and ubiquitin-like protein ligase binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and type I interferon-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Used to study Zika fever. Human ortholog(s) of this gene implicated in Zika fever; immunodeficiency 44; and neutropenia. Orthologous to human STAT2 (signal transducer and activator of transcription 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 14.3), thymus adult (RPKM 11.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 76.5 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128106367..128128722)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128270498..128292853)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The redox cycling of STAT2 maintains innate immune homeostasis.
Title: The redox cycling of STAT2 maintains innate immune homeostasis.
FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE(-/-) mice atherosclerosis.
Title: FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE(-/-) mice atherosclerosis.
Evaluating the Safety of West Nile Virus Immunity During Congenital Zika Virus Infection in Mice.
Title: Evaluating the Safety of West Nile Virus Immunity During Congenital Zika Virus Infection in Mice.
Targeted Stat2 deletion in conventional dendritic cells impairs CTL responses but does not affect antibody production.
Title: Targeted Stat2 deletion in conventional dendritic cells impairs CTL responses but does not affect antibody production.
Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages.
Title: Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages.
Stat2 loss disrupts damage signalling and is protective in acute pancreatitis.
Title: Stat2 loss disrupts damage signalling and is protective in acute pancreatitis.
STAT2 Limits Host Species Specificity of Human Metapneumovirus.
Title: STAT2 Limits Host Species Specificity of Human Metapneumovirus.
Impaired upregulation of Stat2 gene restrictive to pancreatic beta-cells at the early stage of the encephalomyocarditis infection is responsible for the virus-induced diabetes development.
Title: Impaired upregulation of Stat2 gene restrictive to pancreatic β-cells is responsible for virus-induced diabetes in DBA/2 mice.
Influenza-infected STAT2-/- mice had increased morbidity, viral burden, and inflammation compared to wild-type mice. Absence of STAT2 was associated with increased accumulation of M1, M2 and M1/M2 co-expressing macrophages during influenza-bacterial super-infection. Results suggest that the STAT2 signaling is involved in suppressing macrophage activation and bacterial control during influenza-bacterial super-infection.
Title: STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection.
Both type I IFN and IFN-gamma cause promoter binding of a complete ISGF3 complex containing STAT1, STAT2 and IRF9.
Title: A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (6) 1 citation
Gene trapped (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI255964 (e-PCR)
- UniSTS:180127

AW496480 (e-PCR)
- UniSTS:180132

NoName (e-PCR)
- UniSTS:236485

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in type I interferon-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of ISGF3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ISGF3 complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal transducer and activator of transcription 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019963.2 → NP_064347.1 signal transducer and activator of transcription 2

See identical proteins and their annotated locations for NP_064347.1

Status: VALIDATED

Source sequence(s)

AC135859

Consensus CDS

CCDS24269.1

UniProtKB/TrEMBL

Q3UDU1, Q9QXJ2

Related

ENSMUSP00000082855.3, ENSMUST00000085708.3

Conserved Domains (6) summary

pfam05887
Location:742 → 820

Trypan_PARP; Procyclic acidic repetitive protein (PARP)

cd10373
Location:554 → 704

SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins

smart00964
Location:2 → 123

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:141 → 314

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:316 → 563

STAT_bind; STAT protein, DNA binding domain

pfam12188
Location:853 → 907

STAT2_C; Signal transducer and activator of transcription 2 C terminal