Stat5b signal transducer and activator of transcription 5B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stat5bprovided by MGI
Official Full Name: signal transducer and activator of transcription 5Bprovided by MGI
Primary source: MGI:MGI:103035
See related: Ensembl:ENSMUSG00000020919 AllianceGenome:MGI:103035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in cellular response to growth factor stimulus; growth hormone receptor signaling pathway via JAK-STAT; and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on taurine metabolic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of defense response; and positive regulation of lymphocyte activation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; growth hormone insensitivity syndrome with immune dysregulation 1; and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 41.1), ovary adult (RPKM 18.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.63 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100671557..100741407, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100780731..100859004, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation.
Title: Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation.
The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis.
Title: The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis.
Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes.
Title: Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes.
STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth.
Title: STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth.
Constitutively Active STAT5b Feminizes Mouse Liver Gene Expression.
Title: Constitutively Active STAT5b Feminizes Mouse Liver Gene Expression.
Growth Hormone-induced STAT5B Regulates Star Gene Expression Through a Cooperation With cJUN in Mouse MA-10 Leydig Cells.
Title: Growth Hormone-induced STAT5B Regulates Star Gene Expression Through a Cooperation With cJUN in Mouse MA-10 Leydig Cells.
Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice.
Title: Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice.
Stat5B is required for IgE-Mediated mast cell function in vitro and in vivo.
Title: Stat5B is required for IgE-Mediated mast cell function in vitro and in vivo.
STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.
Title: STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.
The neonatal microenvironment programs innate gammadelta T cells through the transcription factor STAT5.
Title: The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Stat5b (e-PCR), detects polymorphism
- UniSTS:144515

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Peyer's patch development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell differentiation in thymus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of activated T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acute-phase response	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within development of secondary female sexual characteristics	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within development of secondary male sexual characteristics	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within development of secondary male sexual characteristics	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in erythropoietin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female pregnancy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of gamma-delta T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of interleukin-2 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid storage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within luteinization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in luteinization	ISO Inferred from Sequence Orthology more info
acts_upstream_of lymphocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mast cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of myeloid cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within natural killer cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of natural killer cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of natural killer cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of B cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of activated T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fibroblast growth factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-2 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of lymphocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within progesterone metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of steroid metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to interleukin-15	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to interleukin-2	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to interleukin-4	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect taurine metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal transducer and activator of transcription 5B

Names: mammary gland factor STAT5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113563.2 → NP_001107035.1 signal transducer and activator of transcription 5B

See identical proteins and their annotated locations for NP_001107035.1

Status: VALIDATED

Source sequence(s)

AI414876, AK045531, AK150098, AL591466

Consensus CDS

CCDS25438.1

UniProtKB/Swiss-Prot

A2A5D5, P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1, Q9R0X8

Related

ENSMUSP00000004143.3, ENSMUST00000004143.3

Conserved Domains (4) summary

cd10420
Location:573 → 717

SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins

pfam01017
Location:141 → 330

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:332 → 582

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:2 → 124

STAT_int; STAT protein, protein interaction domain
NM_001362682.1 → NP_001349611.1 signal transducer and activator of transcription 5B

Status: VALIDATED

Source sequence(s)

AL591466

Consensus CDS

CCDS25438.1

UniProtKB/Swiss-Prot

A2A5D5, P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1, Q9R0X8

Conserved Domains (4) summary

cd10420
Location:573 → 717

SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins

pfam01017
Location:141 → 330

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:332 → 582

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:2 → 124

STAT_int; STAT protein, protein interaction domain
NM_011489.3 → NP_035619.3 signal transducer and activator of transcription 5B

See identical proteins and their annotated locations for NP_035619.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.

Source sequence(s)

AI414876, AK045531, AK150098, AL591466

Consensus CDS

CCDS25438.1

UniProtKB/Swiss-Prot

A2A5D5, P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1, Q9R0X8

Related

ENSMUSP00000102981.3, ENSMUST00000107358.9

Conserved Domains (4) summary

cd10420
Location:573 → 717

SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins

pfam01017
Location:141 → 330

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:332 → 582

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:2 → 124

STAT_int; STAT protein, protein interaction domain