U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kntc1 kinetochore associated 1 [ Mus musculus (house mouse) ]

Gene ID: 208628, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Kntc1provided by MGI
Official Full Name
kinetochore associated 1provided by MGI
Primary source
MGI:MGI:2673709
See related
Ensembl:ENSMUSG00000029414 AllianceGenome:MGI:2673709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
jgl; D330012D13
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore involved in kinetochore assembly. Predicted to be located in cytoskeleton; cytosol; and plasma membrane. Predicted to be part of RZZ complex. Predicted to be active in cytoplasm and kinetochore microtubule. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and spleen. Orthologous to human KNTC1 (kinetochore associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 6.8), liver E14 (RPKM 6.3) and 14 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Kntc1 in Genome Data Viewer
Location:
5 F; 5 63.17 cM
Exon count:
67
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123887755..123959656)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123749692..123821593)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene arginine/serine-rich coiled-coil 2 Neighboring gene STARR-positive B cell enhancer ABC_E104 Neighboring gene hydroxycarboxylic acid receptor 2 Neighboring gene hydrocarboxylic acid receptor 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
  2. Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Fairfield H, et al. Genome Res, 2015 Jul. PMID 25917818, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to kinetochore involved in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RZZ complex IEA
Inferred from Electronic Annotation
more info
  
part_of RZZ complex ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kinetochore-associated protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042421.1 → NP_001035886.1  kinetochore-associated protein 1

    See identical proteins and their annotated locations for NP_001035886.1

    Status: VALIDATED

    Source sequence(s)
    AC129582, AK172905, BY010626
    Consensus CDS
    CCDS39274.1
    UniProtKB/Swiss-Prot
    Q6A0B3, Q8C3Y4
    Related
    ENSMUSP00000031366.8, ENSMUST00000031366.12
    Conserved Domains (1) summary
    pfam10493
    Location:1582 → 2126
    Rod_C; Rough deal protein C-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    123887755..123959656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530253.5 → XP_006530316.1  kinetochore-associated protein 1 isoform X5

  2. XM_006530252.5 → XP_006530315.1  kinetochore-associated protein 1 isoform X4

  3. XM_006530250.4 → XP_006530313.1  kinetochore-associated protein 1 isoform X2

    Conserved Domains (1) summary
    pfam10493
    Location:1579 → 1962
    Rod_C; Rough deal protein C-terminal region

  4. XM_030254330.1 → XP_030110190.1  kinetochore-associated protein 1 isoform X1

    Conserved Domains (1) summary
    pfam10493
    Location:1427 → 1976
    Rod_C; Rough deal protein C-terminal region

  5. XM_006530251.4 → XP_006530314.1  kinetochore-associated protein 1 isoform X3

    Conserved Domains (1) summary
    pfam10493
    Location:776 → 1325
    Rod_C; Rough deal protein C-terminal region

  6. XM_006530254.2 → XP_006530317.1  kinetochore-associated protein 1 isoform X6

    Conserved Domains (1) summary
    pfam10493
    Location:673 → 1222
    Rod_C; Rough deal protein C-terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C3Y4.2 GenPept UniProtKB/Swiss-Prot:Q8C3Y4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous