Cblb Casitas B-lineage lymphoma b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cblbprovided by MGI
Official Full Name: Casitas B-lineage lymphoma bprovided by MGI
Primary source: MGI:MGI:2146430
See related: Ensembl:ENSMUSG00000022637 AllianceGenome:MGI:2146430
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cbl-b
Summary: Predicted to enable receptor tyrosine kinase binding activity and ubiquitin protein ligase activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway; regulation of postsynaptic neurotransmitter receptor internalization; and regulation protein catabolic process at postsynapse. Acts upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of T cell anergy; and positive regulation of protein metabolic process. Is active in glutamatergic synapse and postsynapse. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.7), CNS E14 (RPKM 6.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B5; 16 32.88 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (51851593..52028410)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (52031230..52208047)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 ubiquitin ligase CBLB regulates innate immune responses and bacterial dissemination during nontuberculous mycobacteria infection.
Title: E3 ubiquitin ligase CBLB regulates innate immune responses and bacterial dissemination during nontuberculous mycobacteria infection.
Exploring the role of CBLB in acute myocardial infarction: transcriptomic, microbiomic, and metabolomic analyses.
Title: Exploring the role of CBLB in acute myocardial infarction: transcriptomic, microbiomic, and metabolomic analyses.
Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.
Title: Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.
T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation.
Title: T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation.
The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes.
Title: The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes.
Involvement of the E3 ubiquitin ligase Cblb in host defense and evaluation of transcriptome during Trueperella pyogenes infection.
Title: Involvement of the E3 ubiquitin ligase Cblb in host defense and evaluation of transcriptome during Trueperella pyogenes infection.
IFT80 negatively regulates osteoclast differentiation via association with Cbl-b to disrupt TRAF6 stabilization and activation.
Title: IFT80 negatively regulates osteoclast differentiation via association with Cbl-b to disrupt TRAF6 stabilization and activation.
Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice.
Title: Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice.
Overproduction of IFNgamma by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity.
Title: Overproduction of IFNγ by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity.
Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells.
Title: Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells.

Submit: New GeneRIF Correction See all GeneRIFs (89)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI429560 (e-PCR)
- UniSTS:166002

AI851073 (e-PCR)
- UniSTS:180913

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell anergy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peptidyl-amino acid modification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of T cell anergy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of platelet-derived growth factor receptor-alpha signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation protein catabolic process at postsynapse	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase CBL-B

Names: RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; casitas B-lineage lymphoma proto-oncogene b; signal transduction protein CBL-B

NP_001028410.1

EC 2.3.2.27

XP_006522010.1

EC 2.3.2.27

XP_006522011.1

EC 2.3.2.27

XP_006522012.1

EC 2.3.2.27

XP_006522013.1

EC 2.3.2.27

XP_006522014.1

EC 2.3.2.27

XP_006522015.1

EC 2.3.2.27

XP_036015751.1

EC 2.3.2.27

XP_036015752.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033238.1 → NP_001028410.1 E3 ubiquitin-protein ligase CBL-B

See identical proteins and their annotated locations for NP_001028410.1

Status: VALIDATED

Source sequence(s)

AK147367, AK161486, AK164519, CJ102432, CJ110973, CJ244362

Consensus CDS

CCDS37355.1

UniProtKB/TrEMBL

B9EKI5

Related

ENSMUSP00000110115.2, ENSMUST00000114471.3

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:887 → 927

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 164

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

51851593..52028410

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521950.4 → XP_006522013.1 E3 ubiquitin-protein ligase CBL-B isoform X1

See identical proteins and their annotated locations for XP_006522013.1

UniProtKB/Swiss-Prot

E9QMY2, Q3TTA7

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:931 → 971

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 165

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_006521949.1 → XP_006522012.1 E3 ubiquitin-protein ligase CBL-B isoform X1

See identical proteins and their annotated locations for XP_006522012.1

UniProtKB/Swiss-Prot

E9QMY2, Q3TTA7

Related

ENSMUSP00000153787.2, ENSMUST00000227879.2

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:931 → 971

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 165

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_036159859.1 → XP_036015752.1 E3 ubiquitin-protein ligase CBL-B isoform X3

UniProtKB/TrEMBL

B9EKI5

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:887 → 927

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 164

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_006521948.1 → XP_006522011.1 E3 ubiquitin-protein ligase CBL-B isoform X1

See identical proteins and their annotated locations for XP_006522011.1

UniProtKB/Swiss-Prot

E9QMY2, Q3TTA7

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:931 → 971

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 165

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_006521951.1 → XP_006522014.1 E3 ubiquitin-protein ligase CBL-B isoform X3

See identical proteins and their annotated locations for XP_006522014.1

UniProtKB/TrEMBL

B9EKI5

Related

ENSMUSP00000154583.2, ENSMUST00000227062.2

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:887 → 927

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 164

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_006521947.1 → XP_006522010.1 E3 ubiquitin-protein ligase CBL-B isoform X1

See identical proteins and their annotated locations for XP_006522010.1

UniProtKB/Swiss-Prot

E9QMY2, Q3TTA7

Related

ENSMUSP00000154755.2, ENSMUST00000226593.2

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:931 → 971

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 165

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_036159858.1 → XP_036015751.1 E3 ubiquitin-protein ligase CBL-B isoform X2

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:891 → 931

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 164

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
XM_006521952.5 → XP_006522015.1 E3 ubiquitin-protein ligase CBL-B isoform X4

UniProtKB/Swiss-Prot

Q3TTA7

Related

ENSMUSP00000153753.2, ENSMUST00000227756.2

Conserved Domains (4) summary

cd09920
Location:96 → 192

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:779 → 819

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cd16709
Location:202 → 267

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02761
Location:19 → 102

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain