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Snx30 sorting nexin family member 30 [ Mus musculus (house mouse) ]

Gene ID: 209131, updated on 2-Nov-2024

Summary

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Official Symbol
Snx30provided by MGI
Official Full Name
sorting nexin family member 30provided by MGI
Primary source
MGI:MGI:2443882
See related
Ensembl:ENSMUSG00000028385 AllianceGenome:MGI:2443882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732481H14Rik; C030041J06Rik
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including endocytic recycling; macroautophagy; and positive regulation of autophagosome assembly. Predicted to be located in early endosome membrane. Predicted to be active in early endosome and phagophore assembly site. Is expressed in several structures, including central nervous system; hemolymphoid system; respiratory system; retina; and thyroid gland. Orthologous to human SNX30 (sorting nexin family member 30). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 5.4), placenta adult (RPKM 4.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Snx30 in Genome Data Viewer
Location:
4 B3; 4 32.81 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (59805137..59904740)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (59805131..59904740)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130308A19 gene Neighboring gene predicted gene, 54283 Neighboring gene STARR-seq mESC enhancer starr_10382 Neighboring gene STARR-positive B cell enhancer ABC_E421 Neighboring gene STARR-seq mESC enhancer starr_10383 Neighboring gene STARR-positive B cell enhancer ABC_E7970 Neighboring gene INTS3 and NABP interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E3493 Neighboring gene STARR-positive B cell enhancer ABC_E6184 Neighboring gene STARR-positive B cell enhancer ABC_E9590 Neighboring gene STARR-positive B cell enhancer ABC_E10237 Neighboring gene STARR-seq mESC enhancer starr_10384 Neighboring gene sorting nexin 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:59891511-59891739 Neighboring gene STARR-positive B cell enhancer ABC_E4632 Neighboring gene solute carrier family 46, member 2 Neighboring gene major urinary protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC106086

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sorting nexin-30
Names
novel PX domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172468.2 → NP_766056.1  sorting nexin-30

    See identical proteins and their annotated locations for NP_766056.1

    Status: VALIDATED

    Source sequence(s)
    AK147437, AL831738, BB645079
    Consensus CDS
    CCDS18226.1
    UniProtKB/Swiss-Prot
    Q3UHE6, Q8CE50
    Related
    ENSMUSP00000030080.7, ENSMUST00000030080.7
    Conserved Domains (2) summary
    cd06860
    Location:91 → 206
    PX_SNX7_30_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 7 and 30
    cd07667
    Location:190 → 429
    BAR_SNX30; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 30

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    59805137..59904740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537724.3 → XP_006537787.1  sorting nexin-30 isoform X1

    See identical proteins and their annotated locations for XP_006537787.1

    Conserved Domains (2) summary
    cd06860
    Location:1 → 102
    PX_SNX7_30_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 7 and 30
    cl12013
    Location:86 → 325
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_006537725.5 → XP_006537788.1  sorting nexin-30 isoform X1

    See identical proteins and their annotated locations for XP_006537788.1

    Conserved Domains (2) summary
    cd06860
    Location:1 → 102
    PX_SNX7_30_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 7 and 30
    cl12013
    Location:86 → 325
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CE50.1 GenPept UniProtKB/Swiss-Prot:Q8CE50

Gene LinkOut

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