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Trp53bp2 transformation related protein 53 binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 209456, updated on 2-Nov-2024

Summary

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Official Symbol
Trp53bp2provided by MGI
Official Full Name
transformation related protein 53 binding protein 2provided by MGI
Primary source
MGI:MGI:2138319
See related
Ensembl:ENSMUSG00000026510 AllianceGenome:MGI:2138319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
53BP2; ASPP2; Tp53bp2; PPP1R13A
Summary
Predicted to enable NF-kappaB binding activity; p53 binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including embryo development; heart development; and response to ionizing radiation. Predicted to be located in cell junction and cytosol. Predicted to be active in nucleus. Predicted to colocalize with perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Used to study chromosome 1q41-q42 deletion syndrome. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 11.1), CNS E11.5 (RPKM 10.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Trp53bp2 in Genome Data Viewer
Location:
1 H5; 1 84.93 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (182236737..182289997)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (182409167..182462436)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene F-box protein 28 Neighboring gene STARR-seq mESC enhancer starr_03278 Neighboring gene STARR-positive B cell enhancer mm9_chr1:184271643-184271944 Neighboring gene STARR-positive B cell enhancer ABC_E5879 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4402 Neighboring gene calpain 2 Neighboring gene STARR-seq mESC enhancer starr_03280 Neighboring gene predicted gene, 37885 Neighboring gene STARR-seq mESC enhancer starr_03281 Neighboring gene STARR-positive B cell enhancer mm9_chr1:184469487-184469788 Neighboring gene predicted gene, 46081 Neighboring gene GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhancing ASPP2 promotes acute liver injury via an inflammatory immunoregulatory mechanism. Zhang X, et al. Front Immunol, 2024. PMID 38840923, Free PMC Article
  2. Dysregulated hepatic lipid metabolism and gut microbiota associated with early-stage NAFLD in ASPP2-deficiency mice. Xie F, et al. Front Immunol, 2022. PMID 36466835, Free PMC Article
  3. RDIVpSGP motif of ASPP2 binds to 14-3-3 and enhances ASPP2/k18/14-3-3 ternary complex formulation to promote BRAF/MEK/ERK signal inhibited cell proliferation in hepatocellular carcinoma. Yang T, et al. Cancer Gene Ther, 2022 Nov. PMID 35504951
  4. ASPP2 reduction attenuates HBV induced chronic liver damage: A hybrid mouse model study. Wang Y, et al. Biochem Biophys Res Commun, 2022 Jun 25. PMID 35436632
  5. New insights into the expanding complexity of the tumor suppressor ASPP2. Kampa KM, et al. Cell Cycle, 2009 Sep 15. PMID 19657229

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhancing ASPP2 promotes acute liver injury via an inflammatory immunoregulatory mechanism.
    Title: Enhancing ASPP2 promotes acute liver injury via an inflammatory immunoregulatory mechanism.
  2. Dysregulated hepatic lipid metabolism and gut microbiota associated with early-stage NAFLD in ASPP2-deficiency mice.
    Title: Dysregulated hepatic lipid metabolism and gut microbiota associated with early-stage NAFLD in ASPP2-deficiency mice.
  3. RDIVpSGP motif of ASPP2 binds to 14-3-3 and enhances ASPP2/k18/14-3-3 ternary complex formulation to promote BRAF/MEK/ERK signal inhibited cell proliferation in hepatocellular carcinoma.
    Title: RDIVpSGP motif of ASPP2 binds to 14-3-3 and enhances ASPP2/k18/14-3-3 ternary complex formulation to promote BRAF/MEK/ERK signal inhibited cell proliferation in hepatocellular carcinoma.
  4. ASPP2 reduction attenuates HBV induced chronic liver damage: A hybrid mouse model study.
    Title: ASPP2 reduction attenuates HBV induced chronic liver damage: A hybrid mouse model study.
  5. Knockout of ASPP2 promotes DEN-induced hepatocarcinogenesis via the NF-kappaB pathway in mice.
    Title: Knockout of ASPP2 promotes DEN-induced hepatocarcinogenesis via the NF-κB pathway in mice.
  6. ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.
    Title: ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.
  7. Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms.
    Title: Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms.
  8. hese data suggest that downregulation of ASPP2 can ameliorate Acute kidney injury induced by I/R through activating autophagy, which may provide a novel therapeutic strage for Acute kidney injury.
    Title: Deficiency of apoptosis-stimulating protein two of p53 ameliorates acute kidney injury induced by ischemia reperfusion in mice through upregulation of autophagy.
  9. identified a previously unreported Merlin-binding protein, apoptosis-stimulated p53 protein 2 (ASPP2, also called Tp53bp2), that bound to closed-conformation Merlin predominately through the FERM domain.
    Title: Proximity biotinylation identifies a set of conformation-specific interactions between Merlin and cell junction proteins.
  10. These results suggest that ASPP2 plays an important role in p53-mediated neuronal apoptosis under gp120 stress.
    Title: ASPP2 involvement in p53-mediated HIV-1 envelope glycoprotein gp120 neurotoxicity in mice cerebrocortical neurons.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables p53 binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
apoptosis-stimulating of p53 protein 2
Names
p53-binding protein 2
p53BP2
tumor protein p53 binding protein, 2
tumor suppressor p53-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173378.3 → NP_775554.2  apoptosis-stimulating of p53 protein 2

    Status: VALIDATED

    Source sequence(s)
    AC131742
    Consensus CDS
    CCDS48476.1
    UniProtKB/Swiss-Prot
    Q3UYM7, Q8CG79, Q8K2L5
    UniProtKB/TrEMBL
    E9QJU8
    Related
    ENSMUSP00000112508.2, ENSMUST00000117245.2
    Conserved Domains (5) summary
    cd00204
    Location:942 → 1053
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:936 → 1022
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:936 → 962
    ANK; ANK repeat [structural motif]
    cl00155
    Location:17 → 90
    UBQ; Ubiquitin-like proteins
    cl17036
    Location:1066 → 1122
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    182236737..182289997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CG79.3 GenPept UniProtKB/Swiss-Prot:Q8CG79

Gene LinkOut

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