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Syngr1 synaptogyrin 1 [ Mus musculus (house mouse) ]

Gene ID: 20972, updated on 2-Nov-2024

Summary

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Official Symbol
Syngr1provided by MGI
Official Full Name
synaptogyrin 1provided by MGI
Primary source
MGI:MGI:1328323
See related
Ensembl:ENSMUSG00000022415 AllianceGenome:MGI:1328323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p29; Syngr1b
Summary
Involved in regulation of long-term neuronal synaptic plasticity and regulation of short-term neuronal synaptic plasticity. Acts upstream of or within cellular response to leukemia inhibitory factor. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human SYNGR1 (synaptogyrin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 56.1), cortex adult (RPKM 51.4) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Syngr1 in Genome Data Viewer
Location:
15 E1; 15 37.85 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79975537..80003702)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80091334..80119501)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 43 Neighboring gene ribosomal protein L3 Neighboring gene predicted gene, 24204 Neighboring gene predicted gene, 31134 Neighboring gene STARR-seq mESC enhancer starr_39220 Neighboring gene STARR-seq mESC enhancer starr_39222 Neighboring gene STARR-positive B cell enhancer ABC_E10868 Neighboring gene predicted gene, 31253 Neighboring gene STARR-seq mESC enhancer starr_39224 Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 1 Neighboring gene mannoside acetylglucosaminyltransferase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhanced functional recovery by levodopa is associated with decreased levels of synaptogyrin following stroke in aged mice. Häggman Henrikson J, et al. Brain Res Bull, 2020 Feb. PMID 31805305
  2. Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. Raja MK, et al. Elife, 2019 May 15. PMID 31090538, Free PMC Article
  3. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Janz R, et al. Neuron, 1999 Nov. PMID 10595519
  4. Characterization of synaptogyrin 3 as a new synaptic vesicle protein. Belizaire R, et al. J Comp Neurol, 2004 Mar 8. PMID 14755516
  5. Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells. Belfort GM, et al. J Biol Chem, 2003 Nov 28. PMID 12928441

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhanced functional recovery by levodopa is associated with decreased levels of synaptogyrin following stroke in aged mice.
    Title: Enhanced functional recovery by levodopa is associated with decreased levels of synaptogyrin following stroke in aged mice.
  2. Cellugyrin and synaptogyrin have roles in facilitating targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment
    Title: Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein targeting ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of short-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synaptogyrin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411782.1 → NP_001398711.1  synaptogyrin-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes a different segment for its 5' UTR, 5' coding region, 3' coding region, and 3' UTR, as compared to variant 1a. The encoded isoform (2) has distinct N- and C-termini, compared to isoform 1a.
    Source sequence(s)
    AC161199

  2. NM_001411783.1 → NP_001398712.1  synaptogyrin-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes a different segment for its 5' UTR and 5' coding region, as compared to variant 1a. The encoded isoform (3) has a distinct N-terminus, compared to isoform 1a.
    Source sequence(s)
    AC161199

  3. NM_009303.3 → NP_033329.1  synaptogyrin-1 isoform 1b

    See identical proteins and their annotated locations for NP_033329.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1b) includes a different segment for its 3' coding region and 3' UTR, as compared to variant 1a. The encoded isoform (1b) has a distinct and shorter C-terminus, compared to isoform 1a.
    Source sequence(s)
    AC161199
    Consensus CDS
    CCDS27658.1
    UniProtKB/TrEMBL
    Q3U6D7
    Related
    ENSMUSP00000009728.7, ENSMUST00000009728.13
    Conserved Domains (1) summary
    pfam01284
    Location:21 → 167
    MARVEL; Membrane-associating domain

  4. NM_207708.2 → NP_997591.1  synaptogyrin-1 isoform 1a

    See identical proteins and their annotated locations for NP_997591.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1a) encodes the longest protein (isoform 1a).
    Source sequence(s)
    AC161199
    Consensus CDS
    CCDS27657.1
    UniProtKB/Swiss-Prot
    B9EI16, O55100, Q543Y5, Q9DCB0
    Related
    ENSMUSP00000009727.6, ENSMUST00000009727.12
    Conserved Domains (1) summary
    pfam01284
    Location:21 → 167
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79975537..80003702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55100.2 GenPept UniProtKB/Swiss-Prot:O55100

Gene LinkOut

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