U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Syngr2 synaptogyrin 2 [ Mus musculus (house mouse) ]

Gene ID: 20973, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Syngr2provided by MGI
Official Full Name
synaptogyrin 2provided by MGI
Primary source
MGI:MGI:1328324
See related
Ensembl:ENSMUSG00000048277 AllianceGenome:MGI:1328324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clast2; cellugyrin
Summary
Predicted to be involved in regulated exocytosis and synaptic vesicle membrane organization. Predicted to act upstream of or within protein targeting. Located in synaptic vesicle. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human SYNGR2 (synaptogyrin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon adult (RPKM 184.2), stomach adult (RPKM 158.3) and 21 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Syngr2 in Genome Data Viewer
Location:
11 E2; 11 82.96 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117700459..117705112)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117809646..117814286)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9147 Neighboring gene predicted gene 11723 Neighboring gene transmembrane channel-like gene family 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117655547-117655805 Neighboring gene RIKEN cDNA 6030468B19 gene Neighboring gene STARR-positive B cell enhancer ABC_E5305 Neighboring gene STARR-positive B cell enhancer ABC_E5306 Neighboring gene thymidine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E11501 Neighboring gene STARR-positive B cell enhancer ABC_E4020 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117693509-117693710 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117693767-117693876 Neighboring gene arylformamidase Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117710178-117710379 Neighboring gene baculoviral IAP repeat-containing 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The C-terminus of GLUT4 targets the transporter to the perinuclear compartment but not to the insulin-responsive vesicles. Li LV, et al. Biochem J, 2009 Apr 1. PMID 19076072, Free PMC Article
  2. Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells. Belfort GM, et al. J Biol Chem, 2003 Nov 28. PMID 12928441
  3. Characterization of the human synaptogyrin gene family. Kedra D, et al. Hum Genet, 1998 Aug. PMID 9760194
  4. TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling. Beaton N, et al. Mol Metab, 2015 Nov. PMID 26629404, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cellugyrin and synaptogyrin have roles in facilitating targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment
    Title: Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein targeting ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic vesicle membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
synaptogyrin-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009304.2 → NP_033330.1  synaptogyrin-2

    See identical proteins and their annotated locations for NP_033330.1

    Status: VALIDATED

    Source sequence(s)
    AK089424, AK150234, BB368123, BY146297
    Consensus CDS
    CCDS25691.1
    UniProtKB/Swiss-Prot
    O55101, Q3TCK2, Q8C225, Q99K83
    UniProtKB/TrEMBL
    B0QZP8
    Related
    ENSMUSP00000026649.8, ENSMUST00000026649.14
    Conserved Domains (1) summary
    pfam01284
    Location:20 → 165
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117700459..117705112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245751.2 → XP_030101611.1  synaptogyrin-2 isoform X1

    UniProtKB/TrEMBL
    H3BJ78
    Related
    ENSMUSP00000134879.2, ENSMUST00000175737.2
    Conserved Domains (1) summary
    pfam01284
    Location:20 → 117
    MARVEL; Membrane-associating domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55101.1 GenPept UniProtKB/Swiss-Prot:O55101

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools