U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gprc6a G protein-coupled receptor, family C, group 6, member A [ Mus musculus (house mouse) ]

Gene ID: 210198, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Gprc6aprovided by MGI
Official Full Name
G protein-coupled receptor, family C, group 6, member Aprovided by MGI
Primary source
MGI:MGI:2429498
See related
Ensembl:ENSMUSG00000019905 AllianceGenome:MGI:2429498
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables G protein-coupled receptor activity. Involved in regulation of testosterone biosynthetic process and response to amino acid. Is active in plasma membrane. Is expressed in several structures, including femur; liver; male reproductive gland or organ; musculature; and spleen. Orthologous to human GPRC6A (G protein-coupled receptor class C group 6 member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gprc6a in Genome Data Viewer
Location:
10 B3; 10 25.66 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (51490919..51507554, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (51614823..51631458, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46224 Neighboring gene family with sequence similarity 162, member B Neighboring gene STARR-seq mESC enhancer starr_26663 Neighboring gene regulatory factor X, 6 Neighboring gene Sumo1 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Extracellular Ca(2+) aggravates IgE-induced allergic reaction in mast cells through GPRC6A, a novel family C G-protein-coupled receptor. Liu G, et al. Life Sci, 2022 Dec 15. PMID 36257460
  2. GPRC6A mediates the non-genomic effects of steroids. Pi M, et al. J Biol Chem, 2010 Dec 17. PMID 20947496, Free PMC Article
  3. No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. Wellendorph P, et al. J Mol Endocrinol, 2009 Mar. PMID 19103720
  4. GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. Pi M, et al. PLoS One, 2008. PMID 19050760, Free PMC Article
  5. The L-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release. Smajilovic S, et al. Amino Acids, 2013 Feb. PMID 22714012

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Extracellular Ca[2+] aggravates IgE-induced allergic reaction in mast cells through GPRC6A, a novel family C G-protein-coupled receptor.
    Title: Extracellular Ca(2+) aggravates IgE-induced allergic reaction in mast cells through GPRC6A, a novel family C G-protein-coupled receptor.
  2. Role of Nutrient-sensing Receptor GPRC6A in Regulating Colonic Group 3 Innate Lymphoid Cells and Inflamed Mucosal Healing.
    Title: Role of Nutrient-sensing Receptor GPRC6A in Regulating Colonic Group 3 Innate Lymphoid Cells and Inflamed Mucosal Healing.
  3. Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis.
    Title: Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis.
  4. Role of GPRC6A in Regulating Hepatic Energy Metabolism in Mice.
    Title: Role of GPRC6A in Regulating Hepatic Energy Metabolism in Mice.
  5. Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice.
    Title: Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice.
  6. If the regulatory functions of GPRC6A identified in mice translate to humans, and polymorphisms in GPRC6A are found to predict racial disparities in human diseases, GPRC6A may be a new gene target to predict, prevent, and treat MetS, PCa, and other disorders impacted by GPRC6A.
    Title: GPRC6A: Jack of all metabolism (or master of none).
  7. findings imply the possibility to ameliorate menopause-induced metabolic disorder by GPRC6A and adiponectin signaling
    Title: Adiponectin receptor 1 resists the decline of serum osteocalcin and GPRC6A expression in ovariectomized mice.
  8. GPCR6A activation by Alum leads to the initiation of innate inflammatory responses whereas it is an important signal for the limitation of adaptive immune responses induced by Alum, partially explained by B cell IL-10.
    Title: GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses.
  9. the loss of osteocalcin/Gprc6a signaling has a profound effect on beta-cell mass accrual during late pancreas morphogenesis
    Title: Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a.
  10. the GPRC6A receptor is involved in regulating exercise behaviour
    Title: Enhanced voluntary wheel running in GPRC6A receptor knockout mice.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (9)  1 citation

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC124360

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of testosterone biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of testosterone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to amino acid IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to amino acid ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G-protein coupled receptor family C group 6 member A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153071.1 → NP_694711.1  G-protein coupled receptor family C group 6 member A precursor

    See identical proteins and their annotated locations for NP_694711.1

    Status: PROVISIONAL

    Source sequence(s)
    AY101365
    Consensus CDS
    CCDS23834.1
    UniProtKB/Swiss-Prot
    Q5DK51, Q5DK52, Q8K4Z6
    Related
    ENSMUSP00000020062.4, ENSMUST00000020062.4
    Conserved Domains (4) summary
    cd06361
    Location:37 → 506
    PBP1_GPC6A_like; Ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor
    pfam00003
    Location:605 → 838
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:75 → 482
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:520 → 571
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    51490919..51507554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4Z6.1 GenPept UniProtKB/Swiss-Prot:Q8K4Z6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous