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Adgrb3 adhesion G protein-coupled receptor B3 [ Mus musculus (house mouse) ]

Gene ID: 210933, updated on 28-Oct-2024

Summary

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Official Symbol
Adgrb3provided by MGI
Official Full Name
adhesion G protein-coupled receptor B3provided by MGI
Primary source
MGI:MGI:2441837
See related
Ensembl:ENSMUSG00000033569 AllianceGenome:MGI:2441837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bai3; A830096D10Rik
Summary
Enables GTPase activator activity. Involved in regulation of dendrite morphogenesis; regulation of synapse maturation; and regulation of synapse pruning. Acts upstream of or within several processes, including motor learning; neuron remodeling; and positive regulation of synapse assembly. Located in postsynapse and synaptic cleft. Is active in cerebellar climbing fiber to Purkinje cell synapse and postsynaptic density membrane. Is expressed in several structures, including brain; lung; skeletal muscle; and testis. Orthologous to human ADGRB3 (adhesion G protein-coupled receptor B3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in CNS E18 (RPKM 11.3), cerebellum adult (RPKM 9.2) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Adgrb3 in Genome Data Viewer
Location:
1 A5; 1 10.39 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (25106557..25869338, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (25067476..25834772, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00455 Neighboring gene STARR-seq mESC enhancer starr_00456 Neighboring gene STARR-seq mESC enhancer starr_00457 Neighboring gene STARR-seq mESC enhancer starr_00458 Neighboring gene predicted gene 9443 Neighboring gene predicted gene 29414 Neighboring gene STARR-seq mESC enhancer starr_00459 Neighboring gene STARR-seq mESC enhancer starr_00460 Neighboring gene STARR-seq mESC enhancer starr_00462 Neighboring gene predicted gene, 20172 Neighboring gene predicted gene, 22260 Neighboring gene STARR-seq mESC enhancer starr_00463 Neighboring gene predicted gene, 25294 Neighboring gene STARR-seq mESC enhancer starr_00464 Neighboring gene predicted gene 9884 Neighboring gene predicted gene, 39614

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in the Cochlea and Is Necessary for Hearing Function in Mice. Saegusa C, et al. Int J Mol Sci, 2023 Dec 4. PMID 38069416, Free PMC Article
  2. Generation and initial characterization of mice lacking full-length BAI3 (ADGRB3) expression. Shiu FH, et al. Basic Clin Pharmacol Toxicol, 2023 Oct. PMID 37337931, Free PMC Article
  3. Regulation of the Bcas1 and Baiap3 transcripts in the subthalamic nucleus in mice recovering from MPTP toxicity. Lauridsen JB, et al. Neurosci Res, 2011 Jul. PMID 21514331
  4. The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Lanoue V, et al. Mol Psychiatry, 2013 Aug. PMID 23628982, Free PMC Article
  5. Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. Kee HJ, et al. J Cereb Blood Flow Metab, 2002 Sep. PMID 12218411

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in the Cochlea and Is Necessary for Hearing Function in Mice.
    Title: Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in the Cochlea and Is Necessary for Hearing Function in Mice.
  2. Generation and initial characterization of mice lacking full-length BAI3 (ADGRB3) expression.
    Title: Generation and initial characterization of mice lacking full-length BAI3 (ADGRB3) expression.
  3. The secreted complement component 1, q subcomponent-like protein 4 (C1qL4) repress myoblast fusion by specifically interacting with G protein-coupled receptor BAI3 (BAI3). Stabilin-2 interacts with BAI3 and stimulates its fusion promoting activity. The resulting activated heterotrimeric G-proteins contribute to the initial recruitment of Elmo proteins to the membrane, which are then stabilized on BAI3.
    Title: Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.
  4. Signal transduction via C1qL1-BAI3 interaction is required for motor learning, triggers pruting of surplus cerebellar climbing fibers, and is required to maintain climbing fiber synapses.
    Title: Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum.
  5. G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates.
    Title: G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates.
  6. results reveal that the BAI3 receptor controls dendritic arborization growth and branching in cultured neurons.
    Title: The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons.
  7. Two transcripts with significant regulation from days 7 to 28 in the 1-methyl-4-phenyl-tetrahydropyridine treated groups are identified: brain specific angiogenesis inhibitor associated protein 3 (Baiap3) and breast carcinoma amplified sequence 1 (Bcas1).
    Title: Regulation of the Bcas1 and Baiap3 transcripts in the subthalamic nucleus in mice recovering from MPTP toxicity.
  8. C1ql proteins are secreted signaling molecules that bind to BAI3 and act, at least in part, to regulate synapse formation and/or maintenance.
    Title: The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation
  • Transposon induced (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107444

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within maintenance of synapse structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within motor learning IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in myoblast fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse pruning IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse pruning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cerebellar climbing fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cerebellar climbing fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic cleft IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adhesion G protein-coupled receptor B3
Names
G protein-coupled receptor BAI3
brain-specific angiogenesis inhibitor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175642.4 → NP_783573.4  adhesion G protein-coupled receptor B3 precursor

    See identical proteins and their annotated locations for NP_783573.4

    Status: VALIDATED

    Source sequence(s)
    AC116556, AK044248, AK129162, BC032251
    Consensus CDS
    CCDS14855.1
    UniProtKB/Swiss-Prot
    G3XA05, Q80ZF8
    UniProtKB/TrEMBL
    Q499E3
    Related
    ENSMUSP00000116231.2, ENSMUST00000151309.8
    Conserved Domains (5) summary
    smart00303
    Location:816 → 867
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:510 → 576
    HormR; Domain present in hormone receptors
    smart00209
    Location:348 → 398
    TSP1; Thrombospondin type 1 repeats
    cd15989
    Location:872 → 1164
    7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:594 → 794
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    25106557..25869338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163215.1 → XP_036019108.1  adhesion G protein-coupled receptor B3 isoform X3

    UniProtKB/TrEMBL
    Q499E3
    Conserved Domains (6) summary
    smart00303
    Location:779 → 830
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:473 → 539
    HormR; Domain present in hormone receptors
    smart00209
    Location:311 → 361
    TSP1; Thrombospondin type 1 repeats
    cd15989
    Location:835 → 1127
    7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:557 → 757
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    pfam19188
    Location:29 → 203
    AGRB_N; Adhesion GPCR B N-terminal region

  2. XM_036163213.1 → XP_036019106.1  adhesion G protein-coupled receptor B3 isoform X1

    UniProtKB/TrEMBL
    Q499E3
    Related
    ENSMUSP00000116759.2, ENSMUST00000146592.8
    Conserved Domains (6) summary
    smart00303
    Location:816 → 867
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:510 → 576
    HormR; Domain present in hormone receptors
    smart00209
    Location:348 → 398
    TSP1; Thrombospondin type 1 repeats
    cd15251
    Location:874 → 1131
    7tmB2_BAI_Adhesion_VII; brain-specific angiogenesis inhibitors, group VII adhesion GPCRs, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:594 → 794
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    pfam19188
    Location:29 → 203
    AGRB_N; Adhesion GPCR B N-terminal region

  3. XM_006495817.5 → XP_006495880.1  adhesion G protein-coupled receptor B3 isoform X2

    UniProtKB/TrEMBL
    Q499E3
    Conserved Domains (5) summary
    smart00303
    Location:816 → 867
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:510 → 576
    HormR; Domain present in hormone receptors
    smart00209
    Location:348 → 398
    TSP1; Thrombospondin type 1 repeats
    cd15989
    Location:872 → 1164
    7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:594 → 794
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  4. XM_036163223.1 → XP_036019116.1  adhesion G protein-coupled receptor B3 isoform X5

    UniProtKB/TrEMBL
    Q8K0A3
    Conserved Domains (3) summary
    smart00303
    Location:228 → 279
    GPS; G-protein-coupled receptor proteolytic site domain
    cd15989
    Location:284 → 576
    7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:6 → 206
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  5. XM_006495818.5 → XP_006495881.1  adhesion G protein-coupled receptor B3 isoform X5

    UniProtKB/TrEMBL
    Q8K0A3
    Conserved Domains (3) summary
    smart00303
    Location:228 → 279
    GPS; G-protein-coupled receptor proteolytic site domain
    cd15989
    Location:284 → 576
    7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:6 → 206
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  6. XM_017319555.3 → XP_017175044.1  adhesion G protein-coupled receptor B3 isoform X4

    UniProtKB/TrEMBL
    Q68FL1
    Conserved Domains (5) summary
    smart00303
    Location:483 → 534
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:177 → 243
    HormR; Domain present in hormone receptors
    smart00209
    Location:15 → 65
    TSP1; Thrombospondin type 1 repeats
    cd15989
    Location:539 → 831
    7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:261 → 461
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  7. XM_036163221.1 → XP_036019114.1  adhesion G protein-coupled receptor B3 isoform X4

    UniProtKB/TrEMBL
    Q68FL1
    Conserved Domains (5) summary
    smart00303
    Location:483 → 534
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:177 → 243
    HormR; Domain present in hormone receptors
    smart00209
    Location:15 → 65
    TSP1; Thrombospondin type 1 repeats
    cd15989
    Location:539 → 831
    7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:261 → 461
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZF8.2 GenPept UniProtKB/Swiss-Prot:Q80ZF8

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