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Bicral BRD4 interacting chromatin remodeling complex associated protein like [ Mus musculus (house mouse) ]

Gene ID: 210982, updated on 28-Oct-2024

Summary

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Official Symbol
Bicralprovided by MGI
Official Full Name
BRD4 interacting chromatin remodeling complex associated protein likeprovided by MGI
Primary source
MGI:MGI:2673855
See related
Ensembl:ENSMUSG00000036568 AllianceGenome:MGI:2673855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gltscr1l; mKIAA0240
Summary
Predicted to be involved in positive regulation of DNA-templated transcription. Part of SWI/SNF complex. Is expressed in several structures, including genitourinary system; heart; nervous system; respiratory system; and sensory organ. Orthologous to human BICRAL (BICRA like chromatin remodeling complex associated protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 3.2), cerebellum adult (RPKM 3.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bicral in Genome Data Viewer
Location:
17 C; 17 22.9 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47109046..47201329, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46798116..46890442, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7539 Neighboring gene STARR-positive B cell enhancer ABC_E7540 Neighboring gene ribosomal protein L7-like 1 Neighboring gene peroxisomal biogenesis factor 39 Neighboring gene STARR-seq mESC enhancer starr_42679 Neighboring gene STARR-seq mESC enhancer starr_42682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:46965989-46966172 Neighboring gene STARR-seq mESC enhancer starr_42687 Neighboring gene STARR-seq mESC enhancer starr_42689 Neighboring gene STARR-positive B cell enhancer ABC_E170 Neighboring gene STARR-seq mESC enhancer starr_42692 Neighboring gene tubulin-specific chaperone C Neighboring gene peripherin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Gatchalian J, et al. Nat Commun, 2018 Dec 3. PMID 30510198, Free PMC Article
  2. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. Alpsoy A, et al. J Biol Chem, 2018 Mar 16. PMID 29374058, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1)  1 citation

General gene information

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Markers

Homology

Clone Names

  • KIAA0240

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of GBAF complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
BRD4-interacting chromatin-remodeling complex-associated protein-like
Names
GLTSCR1-like
GLTSCR1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100452.2 → NP_001093922.1  BRD4-interacting chromatin-remodeling complex-associated protein-like

    See identical proteins and their annotated locations for NP_001093922.1

    Status: VALIDATED

    Source sequence(s)
    CT030702
    Consensus CDS
    CCDS50126.1
    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Related
    ENSMUSP00000156590.2, ENSMUST00000233537.2
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47109046..47201329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160440.1 → XP_036016333.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  2. XM_006523976.4 → XP_006524039.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    See identical proteins and their annotated locations for XP_006524039.1

    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  3. XM_036160439.1 → XP_036016332.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  4. XM_036160438.1 → XP_036016331.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  5. XM_036160437.1 → XP_036016330.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  6. XM_011246345.4 → XP_011244647.2  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  7. XM_017317377.2 → XP_017172866.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  8. XM_036160441.1 → XP_036016334.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  9. XM_011246346.4 → XP_011244648.3  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

    Conserved Domains (2) summary
    PRK07003
    Location:496 → 697
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:712 → 812
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  10. XM_006523974.5 → XP_006524037.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X3

    Conserved Domains (2) summary
    PRK07003
    Location:513 → 714
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:729 → 829
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  11. XM_006523981.5 → XP_006524044.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    See identical proteins and their annotated locations for XP_006524044.1

    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  12. XM_036160436.1 → XP_036016329.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  13. XM_036160435.1 → XP_036016328.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    Q8CHH5
    UniProtKB/TrEMBL
    B2RX81
    Conserved Domains (2) summary
    PRK07003
    Location:492 → 693
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:708 → 808
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  14. XM_006523975.4 → XP_006524038.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X4

    Conserved Domains (2) summary
    PRK07003
    Location:495 → 696
    PRK07003; DNA polymerase III subunit gamma/tau
    pfam15249
    Location:711 → 811
    GLTSCR1; Conserved region of unknown function on GLTSCR protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHH5.2 GenPept UniProtKB/Swiss-Prot:Q8CHH5

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