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Lpcat1 lysophosphatidylcholine acyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 210992, updated on 2-Nov-2024

Summary

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Official Symbol
Lpcat1provided by MGI
Official Full Name
lysophosphatidylcholine acyltransferase 1provided by MGI
Primary source
MGI:MGI:2384812
See related
Ensembl:ENSMUSG00000021608 AllianceGenome:MGI:2384812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rd11; Aytl2; LPCAT; LPCAT-1; mLPCAT1; lysoPAFAT; 2900035H07Rik
Summary
Enables O-acyltransferase activity. Involved in phospholipid biosynthetic process. Acts upstream of or within several processes, including negative regulation of phosphatidylcholine biosynthetic process; positive regulation of protein catabolic process; and surfactant homeostasis. Located in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including eye; genitourinary system; lung; nervous system; and vascular system. Orthologous to human LPCAT1 (lysophosphatidylcholine acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 143.7), liver E14.5 (RPKM 30.7) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Lpcat1 in Genome Data Viewer
Location:
13 C1; 13 39.97 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (73615332..73664539)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73467231..73516420)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34991 Neighboring gene mitochondrial ribosomal protein L36 Neighboring gene ephemeron, early developmental lncRNA Neighboring gene STARR-seq mESC enhancer starr_34992 Neighboring gene solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Neighboring gene CLPTM1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Acyl-CoA:lysophosphatidylcholine acyltransferase I (Lpcat1) catalyzes histone protein O-palmitoylation to regulate mRNA synthesis. Zou C, et al. J Biol Chem, 2011 Aug 12. PMID 21685381, Free PMC Article
  2. Phosphatidylcholine formation by LPCAT1 is regulated by Ca(2+) and the redox status of the cell. Soupene E, et al. BMC Biochem, 2012 Jun 7. PMID 22676268, Free PMC Article
  3. AAV-mediated lysophosphatidylcholine acyltransferase 1 (Lpcat1) gene replacement therapy rescues retinal degeneration in rd11 mice. Dai X, et al. Invest Ophthalmol Vis Sci, 2014 Mar 20. PMID 24557352, Free PMC Article
  4. Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism. Deng X, et al. Biomed Pharmacother, 2022 Nov. PMID 36099794
  5. Lysophosphatidylcholine acyltransferase 1 controls mitochondrial reactive oxygen species generation and survival of retinal photoreceptor cells. Nagata K, et al. J Biol Chem, 2022 Jun. PMID 35452679, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lysophospholipid acyltransferase-mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation.
    Title: Lysophospholipid acyltransferase-mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation.
  2. LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth.
    Title: LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth.
  3. LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3.
    Title: LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3.
  4. Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
    Title: Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
  5. Lysophosphatidylcholine acyltransferase 1 controls mitochondrial reactive oxygen species generation and survival of retinal photoreceptor cells.
    Title: Lysophosphatidylcholine acyltransferase 1 controls mitochondrial reactive oxygen species generation and survival of retinal photoreceptor cells.
  6. ROBO4 deletion ameliorates PAF-mediated skin inflammation via regulating the mRNA translation efficiency of LPCAT1/LPCAT2 and the expression of PAF receptor.
    Title: ROBO4 deletion ameliorates PAF-mediated skin inflammation via regulating the mRNA translation efficiency of LPCAT1/LPCAT2 and the expression of PAF receptor.
  7. These results provide insight into understanding of the retinal degeneration seen in rd11 mice that lack LPCAT1.
    Title: Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids.
  8. LPCAT1 interacts with StarD10 and that amino acids 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction.
    Title: Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically Interacts with Phospholipid Transfer Protein StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type II Cells.
  9. Almost wild-type LPCAT1 expression in photoreceptors with strong rod rhodopsin and M/S cone opsin staining, and normal visually-guided water maze behavioral performances were observed in treated rd11 mice.
    Title: AAV-mediated lysophosphatidylcholine acyltransferase 1 (Lpcat1) gene replacement therapy rescues retinal degeneration in rd11 mice.
  10. Residue Cys-211 of the conserved motif III is not essential for catalysis and not sufficient for sensitivity to treatment by sulfhydryl-modifier agents.
    Title: Phosphatidylcholine formation by LPCAT1 is regulated by Ca(2+) and the redox status of the cell.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC8148

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerophosphocholine O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-alkylglycerophosphocholine O-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-alkylglycerophosphocholine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables lysophosphatidic acid acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plasmalogen synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine acyl-chain remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within surfactant homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysophosphatidylcholine acyltransferase 1
Names
1-acylglycerol-3-phosphate O-acyltransferase
1-acylglycerophosphocholine O-acyltransferase
1-alkenylglycerophosphocholine O-acyltransferase
1-alkylglycerophosphocholine O-acetyltransferase
LPC acyltransferase 1
acetyl-CoA:lyso-PAF acetyltransferase
acetyl-CoA:lyso-platelet-activating factor acetyltransferase
acyltransferase-like 2
lyso-PAF acetyltransferase
lysoPC acyltransferase 1
NP_001355610.1
NP_001355611.1
NP_663351.3
XP_006517252.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368681.1 → NP_001355610.1  lysophosphatidylcholine acyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154547
    Conserved Domains (3) summary
    cd07991
    Location:1 → 212
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG5126
    Location:276 → 375
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam13833
    Location:330 → 380
    EF-hand_8; EF-hand domain pair

  2. NM_001368682.1 → NP_001355611.1  lysophosphatidylcholine acyltransferase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154547, AK046507
    Conserved Domains (3) summary
    cd07991
    Location:1 → 111
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG5126
    Location:175 → 274
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam13833
    Location:229 → 279
    EF-hand_8; EF-hand domain pair

  3. NM_145376.6 → NP_663351.3  lysophosphatidylcholine acyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_663351.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154547
    Consensus CDS
    CCDS36726.1
    UniProtKB/Swiss-Prot
    Q3TAX4, Q3TFD2, Q6NXZ6, Q8BG23, Q8BUX7, Q99JU6
    Related
    ENSMUSP00000022099.9, ENSMUST00000022099.15
    Conserved Domains (5) summary
    cd07991
    Location:103 → 314
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:59 → 242
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    pfam13499
    Location:421 → 479
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:432 → 483
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:384 → 437
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    73615332..73664539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517189.4 → XP_006517252.1  lysophosphatidylcholine acyltransferase 1 isoform X1

    Conserved Domains (3) summary
    COG5126
    Location:127 → 226
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam13833
    Location:181 → 231
    EF-hand_8; EF-hand domain pair
    cl17185
    Location:2 → 63
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TFD2.1 GenPept UniProtKB/Swiss-Prot:Q3TFD2

Gene LinkOut

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