Depdc7 DEP domain containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Depdc7provided by MGI
Official Full Name: DEP domain containing 7provided by MGI
Primary source: MGI:MGI:2139258
See related: Ensembl:ENSMUSG00000027173 AllianceGenome:MGI:2139258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to be involved in intracellular signal transduction. Is expressed in cerebral cortex ventricular layer; liver; and metanephros. Orthologous to human DEPDC7 (DEP domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in placenta adult (RPKM 12.7), liver adult (RPKM 12.4) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 54.91 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (104552129..104573202, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (104721784..104742857, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2)

General gene information

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Markers

AV216087 (e-PCR)
- UniSTS:164168

RH131194 (e-PCR)
- UniSTS:214477

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: DEP domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144804.2 → NP_659053.1 DEP domain-containing protein 7

See identical proteins and their annotated locations for NP_659053.1

Status: VALIDATED

Source sequence(s)

AK134830, DV647572

Consensus CDS

CCDS16492.1

UniProtKB/Swiss-Prot

Q3TN66, Q3UNR5, Q91WS7

Related

ENSMUSP00000028595.8, ENSMUST00000028595.8

Conserved Domains (2) summary

cd04405
Location:194 → 427

RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...

cd04446
Location:39 → 133

DEP_DEPDC4; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.