Dsg1c desmoglein 1 gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dsg1cprovided by MGI
Official Full Name: desmoglein 1 gammaprovided by MGI
Primary source: MGI:MGI:2664358
See related: Ensembl:ENSMUSG00000034774 AllianceGenome:MGI:2664358
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dsg6; dsg1g; Dsg1gamma
Summary: This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 18 A2; 18 11.26 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (20380397..20418088)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (20247340..20285031)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sgk1 regulates Dsg1c expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure.
Title: Sgk1 regulates desmoglein 1 expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure.
Expressed in brain, skeletal muscle, and liver, among other tissues. Similar to Dsg2 in its tissue distribution. Orthologous Dsg1 gamma was not found in human genome, suggesting desmosomal cadherin gene cluster contracted during mammalian evolution.
Title: A novel mouse desmosomal cadherin family member, desmoglein 1 gamma.
Desmogleins 4, 5, and 6 are all expressed in the epidermis but are expressed during different times of mouse development.
Title: Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dsg6-pending (e-PCR), detects polymorphism
- UniSTS:257221

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables gamma-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in desmosome	IBA Inferred from Biological aspect of Ancestor more info
located_in desmosome	IDA Inferred from Direct Assay more info	PubMed
located_in desmosome	ISO Inferred from Sequence Orthology more info
located_in desmosome	TAS Traceable Author Statement more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: desmoglein-1-gamma

Names: desmoglein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181680.2 → NP_859008.1 desmoglein-1-gamma preproprotein

See identical proteins and their annotated locations for NP_859008.1

Status: REVIEWED

Source sequence(s)

AC108943, AK034104, AY192159

Consensus CDS

CCDS29079.1

UniProtKB/Swiss-Prot

Q7TQ61, Q7TSF0

Related

ENSMUSP00000054799.7, ENSMUST00000054128.7

Conserved Domains (3) summary

cd11304
Location:165 → 265

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:73 → 155

CA; Cadherin repeats

pfam01049
Location:616 → 730

Cadherin_C; Cadherin cytoplasmic region