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Hk3 hexokinase 3 [ Mus musculus (house mouse) ]

Gene ID: 212032, updated on 2-Nov-2024

Summary

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Official Symbol
Hk3provided by MGI
Official Full Name
hexokinase 3provided by MGI
Primary source
MGI:MGI:2670962
See related
Ensembl:ENSMUSG00000025877 AllianceGenome:MGI:2670962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HK III; HK-III
Summary
Predicted to enable enzyme binding activity; hexokinase activity; and hormone binding activity. Predicted to be involved in several processes, including fructose 6-phosphate metabolic process; glycolytic process; and negative regulation of hydrogen peroxide-mediated programmed cell death. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; musculoskeletal system; and olfactory epithelium. Orthologous to human HK3 (hexokinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in mammary gland adult (RPKM 8.5), spleen adult (RPKM 6.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Hk3 in Genome Data Viewer
Location:
13 B1; 13 29.8 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55153798..55169233, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55005985..55021475, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930526F13 gene Neighboring gene predicted gene, 31313 Neighboring gene unc-5 netrin receptor A Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_34599 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1877 Neighboring gene zinc finger protein 346 Neighboring gene STARR-positive B cell enhancer mm9_chr13:55226322-55226622 Neighboring gene predicted gene, 46415

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of HK3 as a promising immunomodulatory and prognostic target in sepsis-induced acute lung injury. Zhu M, et al. Biochem Biophys Res Commun, 2024 Apr 30. PMID 38484574
  2. Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels. van der Kooij MA, et al. J Mol Med (Berl), 2022 Oct. PMID 35943566, Free PMC Article
  3. Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism. Lundgaard I, et al. Nat Commun, 2015 Apr 23. PMID 25904018, Free PMC Article
  4. Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice. Leite TC, et al. FEBS Lett, 2011 Jan 3. PMID 21074528
  5. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Yavari A, et al. Cell Metab, 2016 May 10. PMID 27133129, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of HK3 as a promising immunomodulatory and prognostic target in sepsis-induced acute lung injury.
    Title: Identification of HK3 as a promising immunomodulatory and prognostic target in sepsis-induced acute lung injury.
  2. Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels.
    Title: Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels.
  3. Hexokinase expression is highly enriched in neurons compared to astrocytes.
    Title: Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC143940

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables fructokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hexokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables hormone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in fructose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fructose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of hydrogen peroxide-mediated programmed cell death ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hexokinase-3
Names
hexokinase type III
hexokinase-C
NP_001028417.1
NP_001193319.1
NP_001193320.1
NP_001193321.1
XP_036013853.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033245.4 → NP_001028417.1  hexokinase-3 isoform 1

    See identical proteins and their annotated locations for NP_001028417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC154610, AK171580, BI133441
    Consensus CDS
    CCDS26538.1
    UniProtKB/Swiss-Prot
    Q3TAX6, Q3TRM8, Q3UDP1, Q3UEA4
    UniProtKB/TrEMBL
    Q3TBG9, Q3TQE0, Q3TVQ4
    Related
    ENSMUSP00000051215.7, ENSMUST00000052949.13
    Conserved Domains (3) summary
    PLN02914
    Location:70 → 469
    PLN02914; hexokinase
    pfam00349
    Location:480 → 672
    Hexokinase_1
    pfam03727
    Location:678 → 912
    Hexokinase_2

  2. NM_001206390.1 → NP_001193319.1  hexokinase-3 isoform 1

    See identical proteins and their annotated locations for NP_001193319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS26538.1
    UniProtKB/Swiss-Prot
    Q3TAX6, Q3TRM8, Q3UDP1, Q3UEA4
    UniProtKB/TrEMBL
    Q3TBG9, Q3TQE0, Q3TVQ4
    Related
    ENSMUSP00000123233.2, ENSMUST00000126234.8
    Conserved Domains (3) summary
    PLN02914
    Location:70 → 469
    PLN02914; hexokinase
    pfam00349
    Location:480 → 672
    Hexokinase_1
    pfam03727
    Location:678 → 912
    Hexokinase_2

  3. NM_001206391.1 → NP_001193320.1  hexokinase-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS56884.1
    UniProtKB/TrEMBL
    E9Q8S8, Q08EC2
    Related
    ENSMUSP00000116717.2, ENSMUST00000123097.8
    Conserved Domains (3) summary
    PTZ00107
    Location:429 → 868
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:435 → 627
    Hexokinase_1; Hexokinase
    pfam03727
    Location:633 → 867
    Hexokinase_2; Hexokinase

  4. NM_001206392.1 → NP_001193321.1  hexokinase-3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS56883.1
    UniProtKB/TrEMBL
    E9Q3Z4, Q3TCB2
    Related
    ENSMUSP00000115227.2, ENSMUST00000153665.8
    Conserved Domains (3) summary
    PLN02914
    Location:15 → 414
    PLN02914; hexokinase
    pfam00349
    Location:425 → 617
    Hexokinase_1
    pfam03727
    Location:623 → 857
    Hexokinase_2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55153798..55169233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157960.1 → XP_036013853.1  hexokinase-3 isoform X1

    UniProtKB/TrEMBL
    E9Q3Z4, Q3TCB2
    Conserved Domains (3) summary
    PLN02914
    Location:15 → 414
    PLN02914; hexokinase
    pfam00349
    Location:425 → 617
    Hexokinase_1
    pfam03727
    Location:623 → 857
    Hexokinase_2

RNA

  1. XR_004938008.1 RNA Sequence

    Related
    ENSMUST00000132309.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TRM8.2 GenPept UniProtKB/Swiss-Prot:Q3TRM8

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