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Mms22l MMS22-like, DNA repair protein [ Mus musculus (house mouse) ]

Gene ID: 212377, updated on 2-Nov-2024

Summary

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Official Symbol
Mms22lprovided by MGI
Official Full Name
MMS22-like, DNA repair proteinprovided by MGI
Primary source
MGI:MGI:2684980
See related
Ensembl:ENSMUSG00000045751 AllianceGenome:MGI:2684980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm134; F730047E07Rik
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; protein localization to chromatin; and replication fork processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of FACT complex and MCM complex. Predicted to be active in nuclear replication fork and site of double-strand break. Is expressed in cerebral cortex ventricular layer. Orthologous to human MMS22L (MMS22 like, DNA repair protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14.5 (RPKM 6.1), CNS E11.5 (RPKM 6.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Mms22l in Genome Data Viewer
Location:
4 A3; 4 10.36 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (24496451..24602950)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (24496451..24602950)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09772 Neighboring gene predicted gene, 31145 Neighboring gene predicted gene 27243 Neighboring gene STARR-seq mESC enhancer starr_09774 Neighboring gene tubulin, beta 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09775 Neighboring gene STARR-seq mESC enhancer starr_09776 Neighboring gene STARR-seq mESC enhancer starr_09777 Neighboring gene STARR-seq mESC enhancer starr_09778 Neighboring gene STARR-seq mESC enhancer starr_09780 Neighboring gene STARR-seq mESC enhancer starr_09781 Neighboring gene kelch-like 32 Neighboring gene predicted gene, 31436 Neighboring gene predicted gene, 31379

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
  2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to chromatin IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
involved_in replication fork processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of FACT complex ISO
Inferred from Sequence Orthology
more info
  
part_of FACT complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of MCM complex ISO
Inferred from Sequence Orthology
more info
  
part_of MCM complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear replication fork ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in site of double-strand break IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein MMS22-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199467.3 → NP_955761.2  protein MMS22-like

    See identical proteins and their annotated locations for NP_955761.2

    Status: VALIDATED

    Source sequence(s)
    AK089531, AK164069, BC094429, BX296536, CK639437
    Consensus CDS
    CCDS18006.2
    UniProtKB/Swiss-Prot
    B1AUR6, B7ZN61, D3YXA0, Q6R5F9, Q80UT0
    UniProtKB/TrEMBL
    G8JL47
    Related
    ENSMUSP00000103857.3, ENSMUST00000108222.9
    Conserved Domains (2) summary
    pfam14910
    Location:26 → 730
    MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
    pfam14911
    Location:849 → 1225
    MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

RNA

  1. NR_149739.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK089531, AK164069, AL671913, BC094429, BE623427, BX296536, CK639437

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    24496451..24602950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537730.4 → XP_006537793.1  protein MMS22-like isoform X1

    See identical proteins and their annotated locations for XP_006537793.1

    UniProtKB/TrEMBL
    G8JL47
    Conserved Domains (2) summary
    pfam14910
    Location:26 → 730
    MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
    pfam14911
    Location:850 → 1226
    MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

  2. XM_036163937.1 → XP_036019830.1  protein MMS22-like isoform X1

    UniProtKB/TrEMBL
    G8JL47
    Conserved Domains (2) summary
    pfam14910
    Location:26 → 730
    MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
    pfam14911
    Location:850 → 1226
    MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

  3. XM_036163938.1 → XP_036019831.1  protein MMS22-like isoform X2

    UniProtKB/Swiss-Prot
    B1AUR6, B7ZN61, D3YXA0, Q6R5F9, Q80UT0
    UniProtKB/TrEMBL
    G8JL47
    Conserved Domains (2) summary
    pfam14910
    Location:26 → 730
    MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
    pfam14911
    Location:849 → 1225
    MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

  4. XM_036163939.1 → XP_036019832.1  protein MMS22-like isoform X3

    Conserved Domains (2) summary
    pfam14910
    Location:11 → 369
    MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
    pfam14911
    Location:489 → 865
    MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

  5. XM_011249970.4 → XP_011248272.1  protein MMS22-like isoform X4

    Conserved Domains (2) summary
    pfam14910
    Location:29 → 249
    MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
    pfam14911
    Location:369 → 745
    MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

RNA

  1. XR_003954900.1 RNA Sequence

  2. XR_003954899.1 RNA Sequence

  3. XR_004941857.1 RNA Sequence

    Related
    ENSMUST00000154349.9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AUR6.1 GenPept UniProtKB/Swiss-Prot:B1AUR6

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