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Paox polyamine oxidase (exo-N4-amino) [ Mus musculus (house mouse) ]

Gene ID: 212503, updated on 2-Nov-2024

Summary

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Official Symbol
Paoxprovided by MGI
Official Full Name
polyamine oxidase (exo-N4-amino)provided by MGI
Primary source
MGI:MGI:1916983
See related
Ensembl:ENSMUSG00000025464 AllianceGenome:MGI:1916983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pao; 2410012F02Rik
Summary
Enables polyamine oxidase activity. Acts upstream of or within polyamine catabolic process. Predicted to be located in peroxisomal matrix. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human PAOX (polyamine oxidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver adult (RPKM 11.4), ovary adult (RPKM 8.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Paox in Genome Data Viewer
Location:
7 F4; 7 85.14 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139693182..139714249)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140115735..140134334)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene proline-rich acidic protein 1 Neighboring gene fucose mutarotase Neighboring gene enoyl Coenzyme A hydratase, short chain, 1, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E1747 Neighboring gene mitochondrial ribosome-associated GTPase 1 Neighboring gene shadow of prion protein Neighboring gene olfactory receptor family 6 subfamily AE member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mechanistic studies of para-substituted N,N'-dibenzyl-1,4-diaminobutanes as substrates for a mammalian polyamine oxidase. Pozzi MH, et al. Biochemistry, 2009 Dec 29. PMID 19911805, Free PMC Article
  2. Inhibition of polyamine and spermine oxidases by polyamine analogues. Bianchi M, et al. FEBS J, 2006 Mar. PMID 16519678
  3. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Royo M, et al. Biochemistry, 2005 May 10. PMID 15865452, Free PMC Article
  4. Mechanistic studies of the role of a conserved histidine in a mammalian polyamine oxidase. Tormos JR, et al. Arch Biochem Biophys, 2012 Dec 1. PMID 22959971, Free PMC Article
  5. A lysine conserved in the monoamine oxidase family is involved in oxidation of the reduced flavin in mouse polyamine oxidase. Henderson Pozzi M, et al. Arch Biochem Biophys, 2010 Jun 15. PMID 20417173, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Steady-state kinetics of His64 mutant proteins shows that the mutations result in a decrease of ~15-fold in the rate constant for amine oxidation.
    Title: Mechanistic studies of the role of a conserved histidine in a mammalian polyamine oxidase.
  2. N,N'-dibenzyl-1,4-diaminobutanes, with only two nitrogens, are also substrates of polyamine oxidase.
    Title: Mechanistic studies of para-substituted N,N'-dibenzyl-1,4-diaminobutanes as substrates for a mammalian polyamine oxidase.
  3. translated amino acid sequences of mpao and bpao have a -Pro-Arg-Leu peroxisomal targeting signal at the extreme C termini and a beta-alpha-beta FAD-binding motif is present in the N-terminal portion of mPAO.
    Title: Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase.
  4. new mechanism for pathogen-induced oxidative stress in macrophages in which activation of PAO1 leads to H(2)O(2) release and apoptosis by a mitochondrial-dependent cell death pathway
    Title: Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables polyamine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyamine oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polyamine oxidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables spermine oxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within polyamine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within polyamine catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in polyamine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of spermidine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in putrescine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in putrescine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in putrescine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in putrescine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in spermidine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in spermine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermine catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Names
exo-N4-amino
peroxisomal N1-acetyl-spermine/spermidine oxidase
NP_001333654.1
NP_722478.2
XP_006536229.4
XP_006536230.1
XP_006536231.1
XP_011248141.1
XP_011248143.3
XP_017177591.1
XP_017177592.1
XP_030098194.1
XP_036008771.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346725.2 → NP_001333654.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109205
    Consensus CDS
    CCDS85452.1
    UniProtKB/TrEMBL
    Q3TXR6
    Related
    ENSMUSP00000095580.4, ENSMUST00000097967.4

  2. NM_153783.4 → NP_722478.2  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 1

    See identical proteins and their annotated locations for NP_722478.2

    Status: VALIDATED

    Source sequence(s)
    AC109205
    Consensus CDS
    CCDS21965.1
    UniProtKB/Swiss-Prot
    Q8C0L6, Q8K254
    UniProtKB/TrEMBL
    Q4GX45
    Related
    ENSMUSP00000026537.6, ENSMUST00000026537.13
    Conserved Domains (2) summary
    PLN02568
    Location:6 → 490
    PLN02568; polyamine oxidase
    pfam13450
    Location:10 → 79
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139693182..139714249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249839.4 → XP_011248141.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X2

    See identical proteins and their annotated locations for XP_011248141.1

    UniProtKB/TrEMBL
    Q4GX45
    Conserved Domains (1) summary
    PLN02568
    Location:3 → 440
    PLN02568; polyamine oxidase

  2. XM_030242334.2 → XP_030098194.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X5

    Conserved Domains (1) summary
    PLN02568
    Location:42 → 386
    PLN02568; polyamine oxidase

  3. XM_011249841.4 → XP_011248143.3  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X6

    Conserved Domains (1) summary
    PLN02568
    Location:105 → 380
    PLN02568; polyamine oxidase

  4. XM_017322103.3 → XP_017177592.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X5

    Conserved Domains (1) summary
    PLN02568
    Location:42 → 386
    PLN02568; polyamine oxidase

  5. XM_006536166.4 → XP_006536229.4  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X1

    UniProtKB/TrEMBL
    Q4GX45
    Conserved Domains (1) summary
    PLN02568
    Location:141 → 485
    PLN02568; polyamine oxidase

  6. XM_036152878.1 → XP_036008771.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X2

    UniProtKB/TrEMBL
    Q4GX45
    Conserved Domains (1) summary
    PLN02568
    Location:3 → 440
    PLN02568; polyamine oxidase

  7. XM_006536167.5 → XP_006536230.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X4

    Conserved Domains (1) summary
    PLN02568
    Location:6 → 323
    PLN02568; polyamine oxidase

  8. XM_017322102.3 → XP_017177591.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X3

    Conserved Domains (1) summary
    PLN02568
    Location:6 → 323
    PLN02568; polyamine oxidase

  9. XM_006536168.4 → XP_006536231.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X5

    Conserved Domains (1) summary
    PLN02568
    Location:42 → 386
    PLN02568; polyamine oxidase

RNA

  1. XR_001785516.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0L6.3 GenPept UniProtKB/Swiss-Prot:Q8C0L6

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