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Ddx46 DEAD box helicase 46 [ Mus musculus (house mouse) ]

Gene ID: 212880, updated on 2-Nov-2024

Summary

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Official Symbol
Ddx46provided by MGI
Official Full Name
DEAD box helicase 46provided by MGI
Primary source
MGI:MGI:1920895
See related
Ensembl:ENSMUSG00000021500 AllianceGenome:MGI:1920895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0801; 2200005K02Rik; 8430438J23Rik
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to be located in fibrillar center and nuclear speck. Predicted to be part of U2-type spliceosomal complex. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer. Orthologous to human DDX46 (DEAD-box helicase 46). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 24.8), CNS E14 (RPKM 15.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ddx46 in Genome Data Viewer
Location:
13 B1; 13 30.06 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55782790..55829080)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55634975..55681267)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene beta-1,4-galactosyltransferase 7 Neighboring gene calcium modulating ligand Neighboring gene RIKEN cDNA B230219D22 gene Neighboring gene STARR-seq mESC enhancer starr_34621 Neighboring gene thioredoxin domain containing 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RNA helicase DDX46 inhibits innate immunity by entrapping m(6)A-demethylated antiviral transcripts in the nucleus. Zheng Q, et al. Nat Immunol, 2017 Oct. PMID 28846086
  2. CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. Wong AW, et al. Nat Immunol, 2003 Sep. PMID 12910265
  3. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  4. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
  5. Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue. Chavez JD, et al. Cell Syst, 2018 Jan 24. PMID 29199018, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31579, MGC116676

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in U2-type prespliceosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in U2-type prespliceosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
part_of U2-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX46
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DEAD box polypeptide 46
DEAD box protein 46
NP_001268984.1
XP_006517265.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282055.1 → NP_001268984.1  probable ATP-dependent RNA helicase DDX46

    See identical proteins and their annotated locations for NP_001268984.1

    Status: VALIDATED

    Source sequence(s)
    AC126408, BC092240, CJ170754
    Consensus CDS
    CCDS70464.1
    UniProtKB/Swiss-Prot
    Q569Z5, Q6ZQ42, Q8R0R6
    Related
    ENSMUSP00000153328.2, ENSMUST00000223736.2
    Conserved Domains (3) summary
    COG0513
    Location:344 → 826
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00268
    Location:378 → 581
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:618 → 714
    Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55782790..55829080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517202.5 → XP_006517265.1  probable ATP-dependent RNA helicase DDX46 isoform X1

    Conserved Domains (2) summary
    COG0513
    Location:344 → 826
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd17953
    Location:361 → 582
    DEADc_DDX46; DEAD-box helicase domain of DEAD box protein 46

RNA

  1. XR_004938009.1 RNA Sequence

  2. XR_873437.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145975.3: Suppressed sequence

    Description
    NM_145975.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q569Z5.2 GenPept UniProtKB/Swiss-Prot:Q569Z5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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