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Evi5l ecotropic viral integration site 5 like [ Mus musculus (house mouse) ]

Gene ID: 213027, updated on 2-Nov-2024

Summary

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Official Symbol
Evi5lprovided by MGI
Official Full Name
ecotropic viral integration site 5 likeprovided by MGI
Primary source
MGI:MGI:2442167
See related
Ensembl:ENSMUSG00000011832 AllianceGenome:MGI:2442167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700084G18Rik; 2310039H16Rik; 3110007G05Rik; B130050I23Rik
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in negative regulation of cilium assembly and positive regulation of GTPase activity. Is expressed in cortical plate. Orthologous to human EVI5L (ecotropic viral integration site 5 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 42.8), CNS E18 (RPKM 22.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Evi5l in Genome Data Viewer
Location:
8 A1.1; 8 1.95 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4216523..4258089)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4166551..4208089)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CD209f antigen Neighboring gene STARR-seq mESC enhancer starr_20605 Neighboring gene CD209g antigen Neighboring gene STARR-seq mESC enhancer starr_20606 Neighboring gene STARR-seq mESC enhancer starr_20608 Neighboring gene RIKEN cDNA 4932443L11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:4162949-4163058 Neighboring gene STARR-positive B cell enhancer ABC_E355 Neighboring gene STARR-seq mESC enhancer starr_20610 Neighboring gene proline rich 36 Neighboring gene leucine rich repeat containing 8 family, member E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vitro selection of Jun-associated proteins using mRNA display. Horisawa K, et al. Nucleic Acids Res, 2004 Dec 2. PMID 15576676, Free PMC Article
  2. Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l. Anderson AE, et al. Mol Cell Biol, 2017 Mar 1. PMID 27956704, Free PMC Article
  3. Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Chai G, et al. Neuron, 2021 Jan 20. PMID 33220177, Free PMC Article
  4. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123
  5. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29047

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
EVI5-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039578.4 → NP_001034667.4  EVI5-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123029, AK045240
    Consensus CDS
    CCDS40207.2
    UniProtKB/TrEMBL
    A0A6I8MWZ4, H3BJX1
    Related
    ENSMUSP00000159328.2, ENSMUST00000239400.2
    Conserved Domains (1) summary
    smart00164
    Location:112 → 320
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  2. NM_001346730.2 → NP_001333659.2  EVI5-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123029
    Consensus CDS
    CCDS85495.1
    UniProtKB/TrEMBL
    H3BJ67, H3BKQ3
    Related
    ENSMUSP00000135479.3, ENSMUST00000176149.9
    Conserved Domains (2) summary
    smart00164
    Location:112 → 320
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:358 → 715
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. NM_001368791.1 → NP_001355720.1  EVI5-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123029
    UniProtKB/TrEMBL
    H3BJ67
    Conserved Domains (2) summary
    smart00164
    Location:133 → 341
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    TIGR02168
    Location:379 → 729
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. NM_001368792.1 → NP_001355721.1  EVI5-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123029
    UniProtKB/TrEMBL
    H3BJ67
    Conserved Domains (2) summary
    smart00164
    Location:133 → 341
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:379 → 736
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. NM_001368794.1 → NP_001355723.1  EVI5-like protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123029
    UniProtKB/TrEMBL
    H3BJ67, H3BL92
    Related
    ENSMUSP00000135700.3, ENSMUST00000176825.3
    Conserved Domains (2) summary
    smart00164
    Location:112 → 320
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    TIGR02168
    Location:358 → 708
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    4216523..4258089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153868.1 → XP_036009761.1  EVI5-like protein isoform X1

    UniProtKB/TrEMBL
    H3BJ67
    Conserved Domains (2) summary
    smart00164
    Location:22 → 230
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:268 → 625
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_036153869.1 → XP_036009762.1  EVI5-like protein isoform X2

    UniProtKB/TrEMBL
    H3BJ67
    Conserved Domains (2) summary
    smart00164
    Location:22 → 230
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:268 → 590
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_006508749.3 → XP_006508812.1  EVI5-like protein isoform X3

    UniProtKB/TrEMBL
    H3BJX1
    Conserved Domains (1) summary
    smart00164
    Location:133 → 341
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RNA

  1. XR_004934796.1 RNA Sequence

  2. XR_004934795.1 RNA Sequence

  3. XR_004934794.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153536.2: Suppressed sequence

    Description
    NM_153536.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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