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Gabpb2 GA repeat binding protein, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 213054, updated on 2-Nov-2024

Summary

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Official Symbol
Gabpb2provided by MGI
Official Full Name
GA repeat binding protein, beta 2provided by MGI
Primary source
MGI:MGI:95612
See related
Ensembl:ENSMUSG00000038766 AllianceGenome:MGI:95612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gabpb2-1; 5830427M07; 1810015F01Rik; 9430006E19Rik; A430024B14Rik
Summary
Enables identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human GABPB2 (GA binding protein transcription factor subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 10.1), liver E14 (RPKM 9.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gabpb2 in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95089077..95125291, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95181766..95218110, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9169 Neighboring gene STARR-seq mESC enhancer starr_08369 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C Neighboring gene STARR-seq mESC enhancer starr_08372 Neighboring gene predicted gene, 16740 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GABPbeta2 is dispensible for normal lymphocyte development but moderately affects B cell responses. Jing X, et al. J Biol Chem, 2008 Sep 5. PMID 18628204, Free PMC Article
  2. Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells. Yu S, et al. Cell Stem Cell, 2012 Aug 3. PMID 22862946, Free PMC Article
  3. Neuregulin-1-stimulated phosphorylation of GABP in skeletal muscle cells. Fromm L, et al. Biochemistry, 2001 May 1. PMID 11318655
  4. Genes encoding the acetaminophen and selenium binding proteins map to mouse chromosome 3. Navarro CL, et al. Mamm Genome, 1996 Dec. PMID 8995767
  5. p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Mardaryev AN, et al. Development, 2014 Jan. PMID 24346698, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The findings identify the tetramer-forming GABPbeta2 as specific HSC regulators and potential therapeutic targets in treating LSC-based hematological malignancy.
    Title: Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells.
  2. GABPbeta2 has a distinct role in restraining B cell expansion and humoral responses.
    Title: GABPbeta2 is dispensible for normal lymphocyte development but moderately affects B cell responses.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
GA-binding protein subunit beta-2
Names
GA-binding protein beta-2-1
GABP subunit beta-2
GABP subunit beta-2-1
GABPB-2
NP_084161.1
NP_766100.1
XP_006501313.1
XP_006501314.1
XP_006501315.1
XP_011238360.1
XP_011238361.1
XP_011238362.1
XP_011238363.1
XP_017175004.1
XP_036018887.1
XP_036018888.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029885.1 → NP_084161.1  GA-binding protein subunit beta-2

    See identical proteins and their annotated locations for NP_084161.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC140190, AK141382, BP768545, CJ101339
    Consensus CDS
    CCDS17605.1
    UniProtKB/Swiss-Prot
    A7E218, P81069, Q8CDA6
    Related
    ENSMUSP00000121283.2, ENSMUST00000136139.8
    Conserved Domains (5) summary
    PHA02876
    Location:86 → 193
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:298 → 359
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:42 → 130
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)

  2. NM_172512.2 → NP_766100.1  GA-binding protein subunit beta-2

    See identical proteins and their annotated locations for NP_766100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC140190, AK030849, BP768545, CJ101339
    Consensus CDS
    CCDS17605.1
    UniProtKB/Swiss-Prot
    A7E218, P81069, Q8CDA6
    Related
    ENSMUSP00000102827.2, ENSMUST00000107209.8
    Conserved Domains (5) summary
    PHA02876
    Location:86 → 193
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:298 → 359
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:42 → 130
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95089077..95125291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501252.5 → XP_006501315.1  GA-binding protein subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006501315.1

    UniProtKB/Swiss-Prot
    A7E218, P81069, Q8CDA6
    Conserved Domains (5) summary
    PHA02876
    Location:86 → 193
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:298 → 359
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:42 → 130
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)

  2. XM_006501251.5 → XP_006501314.1  GA-binding protein subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006501314.1

    UniProtKB/Swiss-Prot
    A7E218, P81069, Q8CDA6
    Conserved Domains (5) summary
    PHA02876
    Location:86 → 193
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:298 → 359
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:42 → 130
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)

  3. XM_011240060.4 → XP_011238362.1  GA-binding protein subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_011238362.1

    UniProtKB/Swiss-Prot
    A7E218, P81069, Q8CDA6
    Conserved Domains (5) summary
    PHA02876
    Location:86 → 193
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:298 → 359
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:42 → 130
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)

  4. XM_006501250.5 → XP_006501313.1  GA-binding protein subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006501313.1

    UniProtKB/Swiss-Prot
    A7E218, P81069, Q8CDA6
    Conserved Domains (5) summary
    PHA02876
    Location:86 → 193
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:298 → 359
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:42 → 130
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)

  5. XM_036162994.1 → XP_036018887.1  GA-binding protein subunit beta-2 isoform X3

    Conserved Domains (2) summary
    COG0666
    Location:5 → 77
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:5 → 33
    ANK; ANK repeat [structural motif]

  6. XM_011240059.3 → XP_011238361.1  GA-binding protein subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_011238361.1

    UniProtKB/Swiss-Prot
    A7E218, P81069, Q8CDA6
    Conserved Domains (5) summary
    PHA02876
    Location:86 → 193
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:298 → 359
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:42 → 130
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)

  7. XM_017319515.2 → XP_017175004.1  GA-binding protein subunit beta-2 isoform X2

    UniProtKB/Swiss-Prot
    P81069
    Conserved Domains (4) summary
    PHA02876
    Location:86 → 193
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:42 → 130
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)

  8. XM_011240061.3 → XP_011238363.1  GA-binding protein subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_011238363.1

    UniProtKB/Swiss-Prot
    A7E218, P81069, Q8CDA6
    Conserved Domains (5) summary
    PHA02876
    Location:86 → 193
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:298 → 359
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:42 → 130
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)

  9. XM_011240058.3 → XP_011238360.1  GA-binding protein subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_011238360.1

    UniProtKB/Swiss-Prot
    A7E218, P81069, Q8CDA6
    Conserved Domains (5) summary
    PHA02876
    Location:86 → 193
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:298 → 359
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:42 → 130
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)

  10. XM_036162995.1 → XP_036018888.1  GA-binding protein subunit beta-2 isoform X4

    Conserved Domains (4) summary
    PHA02876
    Location:86 → 193
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:42 → 130
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81069.2 GenPept UniProtKB/Swiss-Prot:P81069

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