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Tapbpl TAP binding protein-like [ Mus musculus (house mouse) ]

Gene ID: 213233, updated on 2-Nov-2024

Summary

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Official Symbol
Tapbplprovided by MGI
Official Full Name
TAP binding protein-likeprovided by MGI
Primary source
MGI:MGI:2384853
See related
Ensembl:ENSMUSG00000038213 AllianceGenome:MGI:2384853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tapbplr; TAPBPL-R
Summary
Predicted to enable MHC class I protein complex binding activity and TAP complex binding activity. Predicted to be involved in negative regulation of antigen processing and presentation of peptide antigen via MHC class I and peptide antigen assembly with MHC class I protein complex. Predicted to be located in endoplasmic reticulum. Predicted to be part of MHC class I peptide loading complex. Orthologous to human TAPBPL (TAP binding protein like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 16.5), large intestine adult (RPKM 16.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Tapbpl in Genome Data Viewer
Location:
6 F3; 6 59.32 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125200890..125208823, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125223927..125231860, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17335 Neighboring gene predicted gene, 52878 Neighboring gene STARR-positive B cell enhancer ABC_E1712 Neighboring gene vesicle-associated membrane protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:125172222-125172506 Neighboring gene RIKEN cDNA E130112N10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6490 Neighboring gene microRNA 8113 Neighboring gene CD27 antigen Neighboring gene predicted gene, 53066

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A human TAPBP (TAPASIN)-related gene, TAPBP-R. Teng MS, et al. Eur J Immunol, 2002 Apr. PMID 11920573
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27679

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class I protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MHC class I protein complex binding IEA
Inferred from Electronic Annotation
more info
  
enables MHC class I protein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables TAP complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class I IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide antigen assembly with MHC class I protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide antigen assembly with MHC class I protein complex IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide antigen assembly with MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of MHC class I peptide loading complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tapasin-related protein
Names
TAP-binding protein-related protein
TAPASIN-R
TAPBP-R
tapasin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145391.2 → NP_663366.2  tapasin-related protein precursor

    See identical proteins and their annotated locations for NP_663366.2

    Status: VALIDATED

    Source sequence(s)
    AA762569, AC140324, BC094656, BX517366
    Consensus CDS
    CCDS20547.1
    UniProtKB/Swiss-Prot
    E9QN33, Q8VD31
    Related
    ENSMUSP00000047105.8, ENSMUST00000043422.8
    Conserved Domains (3) summary
    smart00410
    Location:209 → 299
    IG_like; Immunoglobulin like
    pfam07686
    Location:209 → 306
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:271 → 401
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    125200890..125208823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255302.2 → XP_030111162.1  tapasin-related protein isoform X1

    Conserved Domains (2) summary
    pfam07686
    Location:202 → 289
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:264 → 394
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VD31.2 GenPept UniProtKB/Swiss-Prot:Q8VD31

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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