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Scyl2 SCY1-like 2 (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 213326, updated on 2-Nov-2024

Summary

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Official Symbol
Scyl2provided by MGI
Official Full Name
SCY1-like 2 (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1289172
See related
Ensembl:ENSMUSG00000069539 AllianceGenome:MGI:1289172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CVAK104; D10Ertd802e
Summary
Predicted to enable signaling receptor binding activity. Involved in pyramidal neuron development. Predicted to be located in Golgi apparatus; clathrin-coated vesicle; and endosome membrane. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-4. Orthologous to human SCYL2 (SCY1 like pseudokinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.5), CNS E14 (RPKM 10.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Scyl2 in Genome Data Viewer
Location:
10 C2; 10 45.05 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (89474582..89522179, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (89638720..89686317, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27520 Neighboring gene STARR-positive B cell enhancer ABC_E1404 Neighboring gene STARR-seq mESC enhancer starr_27521 Neighboring gene nuclear receptor subfamily 1, group H, member 4 Neighboring gene solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 Neighboring gene RIKEN cDNA 1500026H17 gene Neighboring gene STARR-positive B cell enhancer ABC_E5164 Neighboring gene STARR-seq mESC enhancer starr_27523 Neighboring gene STARR-positive B cell enhancer ABC_E2334 Neighboring gene ARP6 actin-related protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. Gingras S, et al. J Neurosci, 2015 Jul 22. PMID 26203146, Free PMC Article
  2. Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network. Düwel M, et al. Mol Biol Cell, 2006 Oct. PMID 16914521, Free PMC Article
  3. A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). Terabayashi T, et al. J Biol Chem, 2009 Sep 25. PMID 19643732, Free PMC Article
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our findings clearly establish the SCY1-like family of protein pseudokinases as key regulators of neuronal function and survival.
    Title: SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in brain development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in pyramidal neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor internalization IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SCY1-like protein 2
Names
coated vesicle-associated kinase of 104 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310704.2 → NP_001297633.1  SCY1-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127279, AI661906
    Consensus CDS
    CCDS78881.1
    UniProtKB/TrEMBL
    G5E8J9
    Related
    ENSMUSP00000089874.6, ENSMUST00000092227.12
    Conserved Domains (4) summary
    smart00220
    Location:32 → 327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08430
    Location:741 → 873
    Forkhead_N; Forkhead N-terminal region
    cd14011
    Location:38 → 329
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    sd00044
    Location:373 → 403
    HEAT; HEAT repeat [structural motif]

  2. NM_001358843.1 → NP_001345772.1  SCY1-like protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127279, AI661906, CB247519, CN528758
    Conserved Domains (3) summary
    cd14011
    Location:38 → 329
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    sd00044
    Location:373 → 403
    HEAT; HEAT repeat [structural motif]
    pfam08430
    Location:745 → 883
    Forkhead_N; Forkhead N-terminal region

  3. NM_198021.3 → NP_932138.1  SCY1-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_932138.1

    Status: VALIDATED

    Source sequence(s)
    AC127279, AI661906
    Consensus CDS
    CCDS36027.1
    UniProtKB/Swiss-Prot
    Q3UT57, Q3UWU9, Q8CFE4, Q8K0M4
    Related
    ENSMUSP00000133992.2, ENSMUST00000174252.8
    Conserved Domains (4) summary
    smart00220
    Location:32 → 327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08430
    Location:742 → 874
    Forkhead_N; Forkhead N-terminal region
    cd14011
    Location:38 → 329
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    sd00044
    Location:373 → 403
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    89474582..89522179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243394.3 → XP_011241696.1  SCY1-like protein 2 isoform X1

    Conserved Domains (3) summary
    cd14011
    Location:38 → 329
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
    sd00044
    Location:373 → 403
    HEAT; HEAT repeat [structural motif]
    pfam08430
    Location:746 → 884
    Forkhead_N; Forkhead N-terminal region

  2. XM_036155724.1 → XP_036011617.1  SCY1-like protein 2 isoform X2

    Conserved Domains (1) summary
    cd14011
    Location:38 → 329
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFE4.1 GenPept UniProtKB/Swiss-Prot:Q8CFE4

Gene LinkOut

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