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Mfsd4b4 major facilitator superfamily domain containing 4B4 [ Mus musculus (house mouse) ]

Gene ID: 213332, updated on 2-Nov-2024

Summary

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Official Symbol
Mfsd4b4provided by MGI
Official Full Name
major facilitator superfamily domain containing 4B4provided by MGI
Primary source
MGI:MGI:3035041
See related
Ensembl:ENSMUSG00000096687 AllianceGenome:MGI:3035041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable D-glucose transmembrane transporter activity. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 4.3), limb E14.5 (RPKM 4.1) and 28 other tissues See more
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Genomic context

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See Mfsd4b4 in Genome Data Viewer
Location:
10 B1; 10 21.27 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39766009..39775202, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39890013..39899206, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene REV3 like, DNA directed polymerase zeta catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_26404 Neighboring gene STARR-seq mESC enhancer starr_26405 Neighboring gene predicted gene, 22105 Neighboring gene STARR-seq mESC enhancer starr_26406 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene isopentenyl-diphosphate delta isomerase, pseudogene 3 Neighboring gene major facilitator superfamily domain containing 4B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
major facilitator superfamily domain containing 4B4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384225.1 → NP_001371154.1  major facilitator superfamily domain containing 4B4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1and 3 encode the longer isoform (1).
    Source sequence(s)
    AC118733
    UniProtKB/TrEMBL
    J3QNS5
    Related
    ENSMUSP00000136934.2, ENSMUST00000178045.9
    Conserved Domains (1) summary
    cl28910
    Location:7 → 405
    MFS; Major Facilitator Superfamily

  2. NM_001384226.1 → NP_001371155.1  major facilitator superfamily domain containing 4B4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: Variants 2, 4, and 5 encode the shorter isoform (2).
    Source sequence(s)
    AC118733
    UniProtKB/TrEMBL
    J3QPW5
    Related
    ENSMUSP00000137516.2, ENSMUST00000178563.3
    Conserved Domains (1) summary
    cl28910
    Location:1 → 359
    MFS; Major Facilitator Superfamily

  3. NM_001416571.1 → NP_001403500.1  major facilitator superfamily domain containing 4B4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1and 3 encode the longer isoform (1).
    Source sequence(s)
    AC118733
    UniProtKB/TrEMBL
    J3QNS5

  4. NM_001416572.1 → NP_001403501.1  major facilitator superfamily domain containing 4B4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: Variants 2, 4, and 5 encode the shorter isoform (2).
    Source sequence(s)
    AC118733
    UniProtKB/TrEMBL
    J3QPW5

  5. NM_001416573.1 → NP_001403502.1  major facilitator superfamily domain containing 4B4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: Variants 2, 4, and 5 encode the shorter isoform (2).
    Source sequence(s)
    AC118733
    UniProtKB/TrEMBL
    J3QPW5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    39766009..39775202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155725.1 → XP_036011618.1  major facilitator superfamily domain containing 4B4 isoform X1

    UniProtKB/TrEMBL
    J3QNS5
    Conserved Domains (1) summary
    cl28910
    Location:7 → 405
    MFS; Major Facilitator Superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_008345.1: Suppressed sequence

    Description
    NG_008345.1: This RefSeq was permanently suppressed because there is sufficient evidence that this locus is transcribed.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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