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Depp1 DEPP1 autophagy regulator [ Mus musculus (house mouse) ]

Gene ID: 213393, updated on 28-Oct-2024

Summary

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Official Symbol
Depp1provided by MGI
Official Full Name
DEPP1 autophagy regulatorprovided by MGI
Primary source
MGI:MGI:1918730
See related
Ensembl:ENSMUSG00000048489 AllianceGenome:MGI:1918730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Depp; Fseg; 8430408G22Rik
Summary
Predicted to be involved in regulation of autophagy. Located in mitochondrion. Is expressed in endothelium of renal artery and metanephros. Orthologous to human DEPP1 (DEPP autophagy regulator 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in liver adult (RPKM 61.7), liver E18 (RPKM 58.4) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Depp1 in Genome Data Viewer
Location:
6 E3; 6 53.83 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (116627645..116629808)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116650684..116652847)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 422 Neighboring gene STARR-seq mESC enhancer starr_17106 Neighboring gene Ras association (RalGDS/AF-6) domain family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E6474 Neighboring gene microRNA 7043 Neighboring gene STARR-positive B cell enhancer ABC_E2202 Neighboring gene STARR-positive B cell enhancer mm9_chr6:116632394-116632695 Neighboring gene transmembrane protein 72 Neighboring gene predicted gene, 22882

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DEPP Deficiency Contributes to Browning of White Adipose Tissue. Guo F, et al. Int J Mol Sci, 2022 Jun 12. PMID 35743009, Free PMC Article
  2. DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS-induced FGF21. Li W, et al. FASEB J, 2018 Oct. PMID 29702025
  3. Insulin-mediated regulation of decidual protein induced by progesterone (DEPP) in adipose tissue and liver. Kuroda Y, et al. Horm Metab Res, 2010 Mar. PMID 19937567
  4. Accelerated coronary angiogenesis by vegfr1-knockout endocardial cells. Zhang Z, et al. PLoS One, 2013. PMID 23894673, Free PMC Article
  5. Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells. Shin D, et al. Dev Dyn, 2005 Aug. PMID 15977181

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Clone Names

  • MGC6835

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein DEPP1
Names
decidual protein induced by progesterone
fat-specific expressed
fat-specific-expressed gene protein
protein DEPP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166580.1 → NP_001160052.1  protein DEPP1

    See identical proteins and their annotated locations for NP_001160052.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC160973, BC058515
    Consensus CDS
    CCDS51882.1
    UniProtKB/Swiss-Prot
    Q8BU66, Q8K2F3
    Related
    ENSMUSP00000136165.2, ENSMUST00000178241.4
    Conserved Domains (1) summary
    pfam15343
    Location:25 → 205
    DEPP; Decidual protein induced by progesterone family

  2. NM_145980.2 → NP_666092.1  protein DEPP1

    See identical proteins and their annotated locations for NP_666092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AK078806, AK087284, BB683812
    Consensus CDS
    CCDS51882.1
    UniProtKB/Swiss-Prot
    Q8BU66, Q8K2F3
    Related
    ENSMUSP00000070203.6, ENSMUST00000067354.10
    Conserved Domains (1) summary
    pfam15343
    Location:25 → 205
    DEPP; Decidual protein induced by progesterone family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    116627645..116629808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2F3.1 GenPept UniProtKB/Swiss-Prot:Q8K2F3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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