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Arhgap29 Rho GTPase activating protein 29 [ Mus musculus (house mouse) ]

Gene ID: 214137, updated on 2-Nov-2024

Summary

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Official Symbol
Arhgap29provided by MGI
Official Full Name
Rho GTPase activating protein 29provided by MGI
Primary source
MGI:MGI:2443818
See related
Ensembl:ENSMUSG00000039831 AllianceGenome:MGI:2443818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Parg1; A830014I19; 6720461J18Rik; B130017I01Rik
Summary
Predicted to enable GTPase activator activity and PDZ domain binding activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including 1st branchial arch; alimentary system epithelium; facial prominence; meninges; and skin. Orthologous to human ARHGAP29 (Rho GTPase activating protein 29). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 25.9), subcutaneous fat pad adult (RPKM 19.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgap29 in Genome Data Viewer
Location:
3 G1; 3 52.94 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (121746752..121810326)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (121953113..122016677)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34050 Neighboring gene predicted gene, 34119 Neighboring gene predicted gene, 46821 Neighboring gene VISTA enhancer mm435 Neighboring gene ATP-binding cassette, sub-family A member 4 Neighboring gene STARR-positive B cell enhancer ABC_E3466 Neighboring gene predicted gene, 40138 Neighboring gene STARR-seq mESC enhancer starr_08870 Neighboring gene lysine (K)-specific demethylase 4D pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted re-sequencing on 1p22 among non-syndromic orofacial clefts from Han Chinese population. Li MJ, et al. Front Genet, 2022. PMID 36061182, Free PMC Article
  2. MicroRNA-1291 promotes endometrial fibrosis by regulating the ArhGAP29-RhoA/ROCK1 signaling pathway in a murine model. Xu Q, et al. Mol Med Rep, 2017 Oct. PMID 28849001, Free PMC Article
  3. Expression and mutation analyses implicate ARHGAP29 as the etiologic gene for the cleft lip with or without cleft palate locus identified by genome-wide association on chromosome 1p22. Leslie EJ, et al. Birth Defects Res A Clin Mol Teratol, 2012 Nov. PMID 23008150, Free PMC Article
  4. The Mafb cleft-associated variant H131Q is not required for palatogenesis in the mouse. Paul BJ, et al. Dev Dyn, 2021 Oct. PMID 33715275, Free PMC Article
  5. ARHGAP29 Mutation Is Associated with Abnormal Oral Epithelial Adhesions. Paul BJ, et al. J Dent Res, 2017 Oct. PMID 28817352, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 29
Names
PTPL1-associated RhoGAP 1
rho-type GTPase-activating protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356524.1 → NP_001343453.1  rho GTPase-activating protein 29

    Status: VALIDATED

    Source sequence(s)
    AC100183
    Consensus CDS
    CCDS17807.1
    UniProtKB/Swiss-Prot
    Q3V135, Q7TMW2, Q8BLJ2, Q8BLR8, Q8CGF1
    Conserved Domains (3) summary
    smart00109
    Location:614 → 659
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:671 → 883
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl12013
    Location:220 → 436
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_172525.3 → NP_766113.1  rho GTPase-activating protein 29

    See identical proteins and their annotated locations for NP_766113.1

    Status: VALIDATED

    Source sequence(s)
    AC100183
    Consensus CDS
    CCDS17807.1
    UniProtKB/Swiss-Prot
    Q3V135, Q7TMW2, Q8BLJ2, Q8BLR8, Q8CGF1
    Related
    ENSMUSP00000044624.8, ENSMUST00000037958.14
    Conserved Domains (3) summary
    smart00109
    Location:614 → 659
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:671 → 883
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl12013
    Location:220 → 436
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    121746752..121810326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501290.3 → XP_006501353.1  rho GTPase-activating protein 29 isoform X2

    See identical proteins and their annotated locations for XP_006501353.1

    Conserved Domains (3) summary
    smart00109
    Location:550 → 595
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:607 → 819
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:156 → 372
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_006501289.4 → XP_006501352.1  rho GTPase-activating protein 29 isoform X1

    See identical proteins and their annotated locations for XP_006501352.1

    Conserved Domains (3) summary
    smart00109
    Location:550 → 595
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:607 → 819
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:156 → 372
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGF1.1 GenPept UniProtKB/Swiss-Prot:Q8CGF1

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