Nudt15 nudix hydrolase 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudt15provided by MGI
Official Full Name: nudix hydrolase 15provided by MGI
Primary source: MGI:MGI:2443366
See related: Ensembl:ENSMUSG00000033405 AllianceGenome:MGI:2443366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MTH2; 6530403O17; A730068G11Rik
Summary: Enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity. Acts upstream of or within purine deoxyribonucleoside triphosphate catabolic process and response to reactive oxygen species. Predicted to be active in cytosol. Used to study leukopenia; neutropenia; and pancytopenia. Human ortholog(s) of this gene implicated in thiopurine S-methyltransferase deficiency. Orthologous to human NUDT15 (nudix hydrolase 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 1.7), heart adult (RPKM 1.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 39.06 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (73756320..73785682, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (73518880..73548242, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nudt15-mediated inflammatory signaling contributes to divergent outcomes in leukemogenesis and hematopoiesis.
Title: Nudt15-mediated inflammatory signaling contributes to divergent outcomes in leukemogenesis and hematopoiesis.
Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells.
Title: Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells.
Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15(R138C) knock-in mice.
Title: Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15(R138C) knock-in mice.
These results suggest that the MTH2 deficiency might be one of the causative factors for accelerated aging.
Title: Age-related alterations in the expression of MTH2 in the hippocampus of the SAMP8 mouse with learning and memory deterioration.
MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals; MTH2 could act as an MTH1 redundancy factor [MTH2]
Title: Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-oxo-dGDP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA protection	IEA Inferred from Electronic Annotation more info
involved_in DNA protection	ISO Inferred from Sequence Orthology more info
involved_in dGTP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dGTP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dGTP catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleoside phosphate catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within purine deoxyribonucleoside triphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in purine nucleotide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nucleotide triphosphate diphosphatase NUDT15

Names: 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15; 8-oxo-dGTPase NUDT15; MutT homolog 2; nucleoside diphosphate-linked moiety X motif 15; nucleoside diphosphate-linked to another moiety X hydrolase 15; nudix (nucleoside diphosphate linked moiety X)-type motif 15; nudix motif 15; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15

NP_001347413.1

EC 3.6.1.9

NP_766115.1

EC 3.6.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360484.1 → NP_001347413.1 nucleotide triphosphate diphosphatase NUDT15

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant, but shorter, transcript. It has a transcriptional start site that is internal relative to that of variant 2. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC113198, AK032657, AK040749, AK043196, BY267802

Consensus CDS

CCDS27270.1

UniProtKB/Swiss-Prot

Q8BG93

UniProtKB/TrEMBL

Q3TH44

Conserved Domains (1) summary

cd04678
Location:27 → 142

Nudix_Hydrolase_19; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
NM_172527.3 → NP_766115.1 nucleotide triphosphate diphosphatase NUDT15

See identical proteins and their annotated locations for NP_766115.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC113198, AK032657, AK040749, AK043196

Consensus CDS

CCDS27270.1

UniProtKB/Swiss-Prot

Q8BG93

UniProtKB/TrEMBL

Q3TH44

Related

ENSMUSP00000039537.2, ENSMUST00000043813.3

Conserved Domains (1) summary

cd04678
Location:27 → 142

Nudix_Hydrolase_19; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...