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Fam168b family with sequence similarity 168, member B [ Mus musculus (house mouse) ]

Gene ID: 214469, updated on 2-Nov-2024

Summary

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Official Symbol
Fam168bprovided by MGI
Official Full Name
family with sequence similarity 168, member Bprovided by MGI
Primary source
MGI:MGI:2448487
See related
Ensembl:ENSMUSG00000037503 AllianceGenome:MGI:2448487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mani; mKIAA4042
Summary
Acts upstream of or within axonogenesis and gene expression. Is active in membrane. Is expressed in endolymphatic appendage and otocyst. Orthologous to human FAM168B (family with sequence similarity 168 member B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 73.1), thymus adult (RPKM 71.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fam168b in Genome Data Viewer
Location:
1 B; 1 13.34 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34852307..34882094, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34813218..34843050, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene STARR-seq mESC enhancer starr_00584 Neighboring gene predicted gene, 32790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:34859246-34859433 Neighboring gene small integral membrane protein 39 Neighboring gene STARR-seq mESC enhancer starr_00587 Neighboring gene pleckstrin homology domain containing, family B (evectins) member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:34924123-34924424 Neighboring gene uncharacterized protein C19orf29 homolog Neighboring gene STARR-seq mESC enhancer starr_00589 Neighboring gene STARR-seq mESC enhancer starr_00590

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The novel protein MANI modulates neurogenesis and neurite-cone growth. Mishra M, et al. J Cell Mol Med, 2011 Aug. PMID 20716133, Free PMC Article
  2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
  3. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Clone Names

  • KIAA4042, MGC58017

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myelin-associated neurite-outgrowth inhibitor
Names
protein FAM168B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160235.2 → NP_001153707.1  myelin-associated neurite-outgrowth inhibitor isoform 1

    See identical proteins and their annotated locations for NP_001153707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site around the middle of the CDS compared to variant 4. It encodes isoform 1, which is shorter than isoform 4.
    Source sequence(s)
    AC107738
    Consensus CDS
    CCDS48236.1
    UniProtKB/TrEMBL
    G3UWF0
    Related
    ENSMUSP00000131720.2, ENSMUST00000167518.8
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 206
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  2. NM_001160236.2 → NP_001153708.1  myelin-associated neurite-outgrowth inhibitor isoform 2

    See identical proteins and their annotated locations for NP_001153708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' CDS compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AC107738
    Consensus CDS
    CCDS48235.1
    UniProtKB/TrEMBL
    E9Q917
    Related
    ENSMUSP00000128676.2, ENSMUST00000170092.8
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 201
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  3. NM_001403152.1 → NP_001390081.1  myelin-associated neurite-outgrowth inhibitor isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AC107738

  4. NM_174997.3 → NP_778162.1  myelin-associated neurite-outgrowth inhibitor isoform 3

    See identical proteins and their annotated locations for NP_778162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' CDS and uses an alternate splice site near the central region of the CDS, compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4.
    Source sequence(s)
    AC107738
    Consensus CDS
    CCDS14873.1
    UniProtKB/Swiss-Prot
    Q3UNC7, Q5DTR7, Q80XQ8
    Related
    ENSMUSP00000042212.6, ENSMUST00000047534.12
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 194
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    34852307..34882094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XQ8.1 GenPept UniProtKB/Swiss-Prot:Q80XQ8

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