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Tcn2 transcobalamin 2 [ Mus musculus (house mouse) ]

Gene ID: 21452, updated on 2-Nov-2024

Summary

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Official Symbol
Tcn2provided by MGI
Official Full Name
transcobalamin 2provided by MGI
Primary source
MGI:MGI:98534
See related
Ensembl:ENSMUSG00000020432 AllianceGenome:MGI:98534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcn-2
Summary
Enables cargo receptor ligand activity and cobalamin binding activity. Involved in cobalamin transport. Is active in external side of plasma membrane and extracellular space. Is expressed in central nervous system; eye; genitourinary system; and liver. Human ortholog(s) of this gene implicated in Parkinson's disease; megaloblastic anemia; and transcobalamin II deficiency. Orthologous to human TCN2 (transcobalamin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 764.5), large intestine adult (RPKM 133.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Tcn2 in Genome Data Viewer
Location:
11 A1; 11 2.76 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3867077..3882078, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3917077..3932078, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921536K21 gene Neighboring gene dual specificity phosphatase 18 Neighboring gene solute carrier family 35, member E4 Neighboring gene STARR-seq mESC enhancer starr_28367 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene pescadillo ribosomal biogenesis factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transport of vitamin B12 into mouse leukemia cells. DiGirolamo PM, et al. Arch Biochem Biophys, 1975 Jun. PMID 237480
  2. Allelic forms of mouse transcobalamin 2. Fràter-Schröder M, et al. Biochem Genet, 1982 Oct. PMID 7181844
  3. Mouse transcobalamin has features resembling both human transcobalamin and haptocorrin. Hygum K, et al. PLoS One, 2011. PMID 21655200, Free PMC Article
  4. The murine leukemia inhibition factor gene (Lif) is located on proximal chromosome 11, not chromosome 13. Bottorff D, et al. Mamm Genome, 1992. PMID 1477476
  5. Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter. Boachie J, et al. Int J Mol Sci, 2021 Mar 17. PMID 33803025, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter.
    Title: Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cargo receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cargo receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
enables cobalamin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cobalamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cobalamin binding ISO
Inferred from Sequence Orthology
more info
  
enables cobalamin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular carrier activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cobalamin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cobalamin transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cobalamin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cobalamin transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cobalt ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transcobalamin-2
Names
TC II
TC-2
TCII
transcobalamin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130458.1 → NP_001123930.1  transcobalamin-2 precursor

    See identical proteins and their annotated locations for NP_001123930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK133707, AK143761, BB849607
    Consensus CDS
    CCDS24371.1
    UniProtKB/Swiss-Prot
    O88968, Q3TD34, Q3UP69, Q5SQ21
    Related
    ENSMUSP00000105620.3, ENSMUST00000109993.9
    Conserved Domains (2) summary
    pfam01122
    Location:11 → 327
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:355 → 428
    DUF4430; Domain of unknown function (DUF4430)

  2. NM_001130459.1 → NP_001123931.1  transcobalamin-2 precursor

    See identical proteins and their annotated locations for NP_001123931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK143761, AK147176
    Consensus CDS
    CCDS24371.1
    UniProtKB/Swiss-Prot
    O88968, Q3TD34, Q3UP69, Q5SQ21
    Related
    ENSMUSP00000105617.2, ENSMUST00000109990.8
    Conserved Domains (2) summary
    pfam01122
    Location:11 → 327
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:355 → 428
    DUF4430; Domain of unknown function (DUF4430)

  3. NM_015749.3 → NP_056564.1  transcobalamin-2 precursor

    See identical proteins and their annotated locations for NP_056564.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1
    Source sequence(s)
    AK143761, AK147176, BB844284
    Consensus CDS
    CCDS24371.1
    UniProtKB/Swiss-Prot
    O88968, Q3TD34, Q3UP69, Q5SQ21
    Related
    ENSMUSP00000105616.4, ENSMUST00000109989.10
    Conserved Domains (2) summary
    pfam01122
    Location:11 → 327
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:355 → 428
    DUF4430; Domain of unknown function (DUF4430)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3867077..3882078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514611.3 → XP_006514674.1  transcobalamin-2 isoform X1

    See identical proteins and their annotated locations for XP_006514674.1

    UniProtKB/Swiss-Prot
    O88968, Q3TD34, Q3UP69, Q5SQ21
    Related
    ENSMUSP00000105618.2, ENSMUST00000109991.8
    Conserved Domains (2) summary
    pfam01122
    Location:11 → 327
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:355 → 428
    DUF4430; Domain of unknown function (DUF4430)

  2. XM_006514610.5 → XP_006514673.1  transcobalamin-2 isoform X1

    See identical proteins and their annotated locations for XP_006514673.1

    UniProtKB/Swiss-Prot
    O88968, Q3TD34, Q3UP69, Q5SQ21
    Related
    ENSMUSP00000020710.5, ENSMUST00000020710.11
    Conserved Domains (2) summary
    pfam01122
    Location:11 → 327
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:355 → 428
    DUF4430; Domain of unknown function (DUF4430)

  3. XM_006514612.4 → XP_006514675.1  transcobalamin-2 isoform X1

    See identical proteins and their annotated locations for XP_006514675.1

    UniProtKB/Swiss-Prot
    O88968, Q3TD34, Q3UP69, Q5SQ21
    Related
    ENSMUSP00000105619.2, ENSMUST00000109992.8
    Conserved Domains (2) summary
    pfam01122
    Location:11 → 327
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:355 → 428
    DUF4430; Domain of unknown function (DUF4430)

  4. XM_006514613.4 → XP_006514676.1  transcobalamin-2 isoform X1

    See identical proteins and their annotated locations for XP_006514676.1

    UniProtKB/Swiss-Prot
    O88968, Q3TD34, Q3UP69, Q5SQ21
    Related
    ENSMUSP00000105615.2, ENSMUST00000109988.2
    Conserved Domains (2) summary
    pfam01122
    Location:11 → 327
    Cobalamin_bind; Eukaryotic cobalamin-binding protein
    pfam14478
    Location:355 → 428
    DUF4430; Domain of unknown function (DUF4430)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88968.1 GenPept UniProtKB/Swiss-Prot:O88968

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