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Tcp10b t-complex protein 10b [ Mus musculus (house mouse) ]

Gene ID: 21462, updated on 2-Nov-2024

Summary

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Official Symbol
Tcp10bprovided by MGI
Official Full Name
t-complex protein 10bprovided by MGI
Primary source
MGI:MGI:98542
See related
Ensembl:ENSMUSG00000055602 AllianceGenome:MGI:98542
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T66B-a; Tcp-10b; Tcp-10bt; D17Leh66B; D17Leh66ba
Summary
Predicted to enable DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human TCP10L (t-complex 10 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 173.2) See more
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Genomic context

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See Tcp10b in Genome Data Viewer
Location:
17 8.76 cM; 17 A1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13279987..13301124)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (13061100..13082237)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 31, D17Leh66b region Neighboring gene predicted gene, 36226 Neighboring gene STARR-seq mESC enhancer starr_41866 Neighboring gene predicted gene 11166 Neighboring gene unc-93 homolog A Neighboring gene predicted gene, 23050

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Concerted evolution of the mouse Tcp-10 gene family: implications for the functional basis of t haplotype transmission ratio distortion. Pilder SH, et al. Genomics, 1992 Jan. PMID 1339385
  2. Functional and molecular characterization of the transcriptional regulatory region of Tcp-10bt, a testes-expressed gene from the t complex responder locus. Ewulonu UK, et al. Development, 1993 Jan. PMID 8223262
  3. An unstable family of large DNA elements in the center of the mouse t complex. Schimenti J, et al. J Mol Biol, 1987 Apr 20. PMID 2821263
  4. Polymorphisms distinguishing different mouse species and t haplotypes. Horiuchi Y, et al. Genet Res, 1992 Aug. PMID 1452014
  5. Targeted mutagenesis of a candidate t complex responder gene in mouse t haplotypes does not eliminate transmission ratio distortion. Ewulonu UK, et al. Genetics, 1996 Oct. PMID 8889539, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
t-complex protein 10b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009341.2 → NP_033367.2  t-complex protein 10b

    Status: VALIDATED

    Source sequence(s)
    AC166360, AK077165
    Consensus CDS
    CCDS28401.1
    UniProtKB/TrEMBL
    E9PYJ0, F6SKG2, Q8C5S9
    Related
    ENSMUSP00000083997.5, ENSMUST00000086787.11
    Conserved Domains (2) summary
    pfam07202
    Location:263 → 436
    Tcp10_C; T-complex protein 10 C-terminus
    pfam15030
    Location:19 → 103
    DUF4527; Protein of unknown function (DUF4527)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    13279987..13301124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523313.2 → XP_006523376.1  t-complex protein 10b isoform X1

    UniProtKB/TrEMBL
    Q8C5S9
    Conserved Domains (1) summary
    pfam07202
    Location:230 → 404
    Tcp10_C; T-complex protein 10 C-terminus
Nucleotide Protein Strain
Heading Accession and Version

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