U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chtf18 CTF18, chromosome transmission fidelity factor 18 [ Mus musculus (house mouse) ]

Gene ID: 214901, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Chtf18provided by MGI
Official Full Name
CTF18, chromosome transmission fidelity factor 18provided by MGI
Primary source
MGI:MGI:2384887
See related
Ensembl:ENSMUSG00000019214 AllianceGenome:MGI:2384887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CTF18; Chl12; 6030457M03Rik
Summary
Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Acts upstream of or within germ cell development; meiotic nuclear division; and negative regulation of chromosome segregation. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and integumental system. Orthologous to human CHTF18 (chromosome transmission fidelity factor 18). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in thymus adult (RPKM 10.4), CNS E11.5 (RPKM 10.3) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Chtf18 in Genome Data Viewer
Location:
17 A3.3; 17 12.83 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25938004..25946409, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25719030..25727434, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930541O19 gene Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene guanine nucleotide binding protein (G protein), gamma 13 Neighboring gene STARR-positive B cell enhancer ABC_E3190 Neighboring gene RNA pseudouridylate synthase domain containing 1 Neighboring gene mesothelin-like Neighboring gene mesothelin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast. Berkowitz KM, et al. Mol Hum Reprod, 2008 Mar. PMID 18250106
  2. CHTF18 ensures the quantity and quality of the ovarian reserve†. Holton RA, et al. Biol Reprod, 2020 Jun 23. PMID 32219340, Free PMC Article
  3. Disruption of CHTF18 causes defective meiotic recombination in male mice. Berkowitz KM, et al. PLoS Genet, 2012. PMID 23133398, Free PMC Article
  4. Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models. Ni L, et al. Mol Reprod Dev, 2016 Dec. PMID 27739607
  5. Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Ulmke PA, et al. Stem Cell Reports, 2021 Apr 13. PMID 33798452, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC38008

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA clamp loader activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to DNA clamp loader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
part_of Ctf18 RFC-like complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
chromosome transmission fidelity protein 18 homolog
Names
CTF18, chromosome transmission fidelity factor 18 homolog
Chl12 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145409.2 → NP_663384.2  chromosome transmission fidelity protein 18 homolog

    See identical proteins and their annotated locations for NP_663384.2

    Status: VALIDATED

    Source sequence(s)
    AK077947, BB861615, BC083096
    Consensus CDS
    CCDS28523.1
    UniProtKB/Swiss-Prot
    Q8BIW9, Q8R1R7
    UniProtKB/TrEMBL
    A0A0R4J0I4
    Related
    ENSMUSP00000043896.8, ENSMUST00000048054.14
    Conserved Domains (2) summary
    cd00009
    Location:347 → 516
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    cl19912
    Location:486 → 553
    DNA_pol3_delta; DNA polymerase III, delta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25938004..25946409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524017.5 → XP_006524080.1  chromosome transmission fidelity protein 18 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8BIW9, Q8R1R7
    UniProtKB/TrEMBL
    E9PVJ3
    Related
    ENSMUSP00000131768.3, ENSMUST00000170070.3
    Conserved Domains (1) summary
    PRK04195
    Location:343 → 589
    PRK04195; replication factor C large subunit; Provisional

  2. XM_030249640.2 → XP_030105500.1  chromosome transmission fidelity protein 18 homolog isoform X2

    Conserved Domains (1) summary
    PRK04195
    Location:1 → 196
    PRK04195; replication factor C large subunit; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIW9.2 GenPept UniProtKB/Swiss-Prot:Q8BIW9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous