Slc39a2 solute carrier family 39 (zinc transporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc39a2provided by MGI
Official Full Name: solute carrier family 39 (zinc transporter), member 2provided by MGI
Primary source: MGI:MGI:2684326
See related: Ensembl:ENSMUSG00000072572 AllianceGenome:MGI:2684326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zip2; Gm289; ZIP-2; hZIP2; Gm1789; F730005G13Rik
Summary: Enables zinc ion transmembrane transporter activity. Involved in keratinocyte differentiation and zinc ion transmembrane transport. Acts upstream of or within zinc ion transport. Located in plasma membrane. Is expressed in several structures, including genitourinary system; gut; liver; spleen; and yolk sac. Orthologous to human SLC39A2 (solute carrier family 39 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 3.9), frontal lobe adult (RPKM 3.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 26.71 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (52130539..52134202)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (51893082..51896745)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of p67(phox) in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3.
Title: Upregulation of p67(phox) in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3.
Loss of Zip2 expression is associated with myocardial ischemia/reperfusion injury.
Title: The critical role of the zinc transporter Zip2 (SLC39A2) in ischemia/reperfusion injury in mouse hearts.
results of this study suggest that ZIP2, a zinc transporter expressed specifically in the epidermis, and zinc taken up by ZIP2 are necessary for the differentiation of keratinocytes
Title: ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation.
ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc
Title: Structure, function, and regulation of a subfamily of mouse zinc transporter genes.
Slc39a2 apparently plays a critical role in zinc homeostasis when zinc is replete, but they play important, noncompensatory roles when this metal is deficient
Title: Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency.
These studies suggest that active expression of the Zip2 gene in these few specific cell types, aforementioned, plays a particularly important role during zinc deficiency.
Title: Targeting of the mouse Slc39a2 (Zip2) gene reveals highly cell-specific patterns of expression, and unique functions in zinc, iron, and calcium homeostasis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:547105

Slc39a2 (e-PCR), detects polymorphism
- UniSTS:547105

Slc39a2 (e-PCR), detects polymorphism
- UniSTS:265584

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cadmium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cadmium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within zinc ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc transporter ZIP2

Names: solute carrier family 39 member 2; zrt- and Irt-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.