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Utp25 UTP25 small subunit processome component [ Mus musculus (house mouse) ]

Gene ID: 215193, updated on 2-Nov-2024

Summary

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Official Symbol
Utp25provided by MGI
Official Full Name
UTP25 small subunit processome componentprovided by MGI
Primary source
MGI:MGI:2138080
See related
Ensembl:ENSMUSG00000016181 AllianceGenome:MGI:2138080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Def; mDef; Diexf
Summary
Predicted to enable U3 snoRNA binding activity and rRNA binding activity. Involved in positive regulation of embryonic development. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in cerebral cortex; submandibular gland primordium; tooth; and vibrissa. Orthologous to human UTP25 (UTP25 small subunit processome component). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 6.5), limb E14.5 (RPKM 4.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Utp25 in Genome Data Viewer
Location:
1 H6; 1 97.56 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (192786707..192812603, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (193104399..193130283, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin XIV Neighboring gene predicted gene, 39746 Neighboring gene predicted gene, 31406 Neighboring gene predicted gene, 39747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194913524-194913725 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194948976-194949260 Neighboring gene STARR-positive B cell enhancer ABC_E3355 Neighboring gene RIKEN cDNA A130010J15 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194995551-194995752 Neighboring gene STARR-positive B cell enhancer ABC_E7790 Neighboring gene interferon regulatory factor 6 Neighboring gene TRAF3 interacting protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ribosome biogenesis gene DEF/UTP25 is essential for liver homeostasis and regeneration. Huang W, et al. Sci China Life Sci, 2020 Nov. PMID 32303961
  2. Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation. Wei J, et al. iScience, 2023 Jul 21. PMID 37456842, Free PMC Article
  3. Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53. Aryal NK, et al. Oncotarget, 2017 Nov 28. PMID 29262616, Free PMC Article
  4. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
  5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ribosome biogenesis gene DEF/UTP25 is essential for liver homeostasis and regeneration.
    Title: Ribosome biogenesis gene DEF/UTP25 is essential for liver homeostasis and regeneration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables U3 snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U3 snoRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in embryonic organ development ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic organ development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein destabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
U3 small nucleolar RNA-associated protein 25 homolog
Names
UTP25 small subunit processor component
digestive-organ expansion factor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368818.2 → NP_001355747.1  U3 small nucleolar RNA-associated protein 25 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL365322
    UniProtKB/Swiss-Prot
    Q8BTT6, Q8BWJ1, Q8VEC2
    Conserved Domains (1) summary
    pfam06862
    Location:175 → 650
    UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

  2. NM_001368819.2 → NP_001355748.1  U3 small nucleolar RNA-associated protein 25 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL365322
    Conserved Domains (1) summary
    pfam06862
    Location:288 → 510
    UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

  3. NM_145415.3 → NP_663390.2  U3 small nucleolar RNA-associated protein 25 homolog isoform 1

    See identical proteins and their annotated locations for NP_663390.2

    Status: VALIDATED

    Source sequence(s)
    AL365322
    Consensus CDS
    CCDS15631.1
    UniProtKB/Swiss-Prot
    Q8BTT6, Q8BWJ1, Q8VEC2
    UniProtKB/TrEMBL
    A0A0R4J114
    Related
    ENSMUSP00000082691.2, ENSMUST00000085555.7
    Conserved Domains (1) summary
    pfam06862
    Location:288 → 763
    UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

RNA

  1. NR_151719.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL365322
    Related
    ENSMUST00000195291.6

  2. NR_185200.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL365322

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    192786707..192812603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252943.2 → XP_030108803.1  U3 small nucleolar RNA-associated protein 25 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8BTT6, Q8BWJ1, Q8VEC2
    Conserved Domains (1) summary
    pfam06862
    Location:175 → 650
    UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

  2. XM_006497250.2 → XP_006497313.1  U3 small nucleolar RNA-associated protein 25 homolog isoform X2

    Conserved Domains (1) summary
    pfam06862
    Location:1 → 466
    UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

RNA

  1. XR_004941611.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTT6.2 GenPept UniProtKB/Swiss-Prot:Q8BTT6

Gene LinkOut

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