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Arrdc1 arrestin domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 215705, updated on 2-Nov-2024

Summary

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Official Symbol
Arrdc1provided by MGI
Official Full Name
arrestin domain containing 1provided by MGI
Primary source
MGI:MGI:2446136
See related
Ensembl:ENSMUSG00000026972 AllianceGenome:MGI:2446136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including arrestin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including extracellular transport; extracellular vesicle biogenesis; and negative regulation of Notch signaling pathway. Predicted to be located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; nasal cavity epithelium; and respiratory system. Orthologous to human ARRDC1 (arrestin domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in stomach adult (RPKM 119.7), colon adult (RPKM 105.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Arrdc1 in Genome Data Viewer
Location:
2 A3; 2 16.84 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24815364..24825347, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24925352..24935335, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, N type, alpha 1B subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:24603469-24603689 Neighboring gene euchromatic histone methyltransferase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:24766046-24766347 Neighboring gene STARR-positive B cell enhancer ABC_E634 Neighboring gene STARR-positive B cell enhancer ABC_E5898 Neighboring gene zinc finger, MYND domain containing 19 Neighboring gene diphthamine biosynethesis 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of the divalent metal ion transporter via membrane budding. Mackenzie K, et al. Cell Discov, 2016. PMID 27462458, Free PMC Article
  2. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
  3. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC28029

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arrestin family protein binding IEA
Inferred from Electronic Annotation
more info
  
enables arrestin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in extracellular transport ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in extracellular vesicle biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular vesicle biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
arrestin domain-containing protein 1
Names
alpha-arrestin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162485.1 → NP_001155957.1  arrestin domain-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_001155957.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL732525
    Consensus CDS
    CCDS50521.1
    UniProtKB/Swiss-Prot
    A2AIS7, A2AIS8, Q3TDT6, Q8VEG7, Q99KN1
    Related
    ENSMUSP00000028349.8, ENSMUST00000028349.14
    Conserved Domains (2) summary
    pfam02752
    Location:162 → 283
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:7 → 139
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

  2. NM_178408.3 → NP_848495.2  arrestin domain-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AL732525
    Consensus CDS
    CCDS15741.1
    UniProtKB/Swiss-Prot
    Q99KN1
    Related
    ENSMUSP00000099999.4, ENSMUST00000102935.10
    Conserved Domains (2) summary
    pfam02752
    Location:162 → 282
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:7 → 139
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

  1. NR_027876.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and contains an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL732525
    Related
    ENSMUST00000155953.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    24815364..24825347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497841.1 → XP_006497904.1  arrestin domain-containing protein 1 isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:244 → 384
    PHA03247; large tegument protein UL36; Provisional
    pfam02752
    Location:117 → 239
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:18 → 94
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

  2. XM_006497839.3 → XP_006497902.1  arrestin domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:288 → 428
    PHA03247; large tegument protein UL36; Provisional
    pfam02752
    Location:162 → 283
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:7 → 139
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

  3. XM_006497838.3 → XP_006497901.1  arrestin domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:289 → 429
    PHA03247; large tegument protein UL36; Provisional
    pfam02752
    Location:162 → 284
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:7 → 139
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

  4. XM_006497840.5 → XP_006497903.1  arrestin domain-containing protein 1 isoform X3

    Conserved Domains (3) summary
    PHA03247
    Location:252 → 392
    PHA03247; large tegument protein UL36; Provisional
    pfam02752
    Location:125 → 247
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:14 → 102
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

  5. XM_030249390.2 → XP_030105250.1  arrestin domain-containing protein 1 isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:252 → 386
    PHA03247; large tegument protein UL36; Provisional
    pfam02752
    Location:125 → 247
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:14 → 102
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

  6. XM_006497842.3 → XP_006497905.1  arrestin domain-containing protein 1 isoform X6

    Conserved Domains (2) summary
    smart01017
    Location:34 → 107
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    PHA03247
    Location:112 → 252
    PHA03247; large tegument protein UL36; Provisional

  7. XM_036160423.1 → XP_036016316.1  arrestin domain-containing protein 1 isoform X7

    Conserved Domains (2) summary
    smart01017
    Location:34 → 107
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    PHA03247
    Location:112 → 246
    PHA03247; large tegument protein UL36; Provisional

  8. XM_030249391.1 → XP_030105251.1  arrestin domain-containing protein 1 isoform X6

    Conserved Domains (2) summary
    smart01017
    Location:34 → 107
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    PHA03247
    Location:112 → 252
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_003952025.2 RNA Sequence

  2. XR_003952030.2 RNA Sequence

  3. XR_004939481.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KN1.2 GenPept UniProtKB/Swiss-Prot:Q99KN1

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