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Rufy1 RUN and FYVE domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 216724, updated on 2-Nov-2024

Summary

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Official Symbol
Rufy1provided by MGI
Official Full Name
RUN and FYVE domain containing 1provided by MGI
Primary source
MGI:MGI:2429762
See related
Ensembl:ENSMUSG00000020375 AllianceGenome:MGI:2429762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rabip4; ZFYVE12; 3000002E04Rik
Summary
Predicted to enable identical protein binding activity; protein domain specific binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within protein transport; regulation of endocytosis; and small GTPase-mediated signal transduction. Located in cytoplasm. Is expressed in brain; genitourinary system; heart; liver; and lung. Orthologous to human RUFY1 (RUN and FYVE domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 5.9), adrenal adult (RPKM 5.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rufy1 in Genome Data Viewer
Location:
11 B1.3; 11 30.57 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50280113..50322101, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50389286..50431274, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6978 Neighboring gene predicted gene, 53701 Neighboring gene microRNA 804 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:50190892-50191075 Neighboring gene STARR-positive B cell enhancer ABC_E2985 Neighboring gene chibby family member 3 Neighboring gene heterogeneous nuclear ribonucleoprotein H1 Neighboring gene STARR-positive B cell enhancer ABC_E2986 Neighboring gene STARR-positive B cell enhancer ABC_E5222 Neighboring gene predicted gene, 53702 Neighboring gene predicted gene, 36763

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4. Mari M, et al. J Biol Chem, 2001 Nov 9. PMID 11509568
  2. 5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity. Ruan QT, et al. FASEB J, 2020 Jul. PMID 32401417, Free PMC Article
  3. Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity. Yazdani N, et al. PLoS Genet, 2015 Dec. PMID 26658939, Free PMC Article
  4. The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes. Mari M, et al. J Cell Sci, 2006 Apr 1. PMID 16522682
  5. The Rab4A effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts. Vukmirica J, et al. J Biol Chem, 2006 Nov 24. PMID 17001082

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rabip4 plays a role in the endocytotic trafficking of Glut4 in 3T3-L1 adipocytes.
    Title: The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.
  2. Rabip4s, possibly via their interaction with Rab4, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
    Title: The Rab4A effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in early endosome to Golgi transport IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to Golgi transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal vesicle fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
NOT located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RUN and FYVE domain-containing protein 1
Names
FYVE-finger containing protein
Rab4a interacting protein
rab4-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172557.3 → NP_766145.1  RUN and FYVE domain-containing protein 1

    See identical proteins and their annotated locations for NP_766145.1

    Status: VALIDATED

    Source sequence(s)
    AK046625, AK046633, BQ176179
    Consensus CDS
    CCDS24635.1
    UniProtKB/Swiss-Prot
    Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6
    Related
    ENSMUSP00000020643.4, ENSMUST00000020643.4
    Conserved Domains (3) summary
    cd15758
    Location:638 → 708
    FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins
    pfam02759
    Location:151 → 274
    RUN; RUN domain
    cl02073
    Location:444 → 589
    DUF3422; Protein of unknown function (DUF3422)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50280113..50322101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532841.5 → XP_006532904.1  RUN and FYVE domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    TIGR02168
    Location:237 → 540
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15758
    Location:545 → 615
    FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins
    pfam02759
    Location:58 → 179
    RUN; RUN domain

  2. XM_017314442.2 → XP_017169931.1  RUN and FYVE domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    pfam02759
    Location:151 → 272
    RUN; RUN domain

RNA

  1. XR_001779949.2 RNA Sequence

  2. XR_004936914.1 RNA Sequence

  3. XR_004936913.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIJ7.1 GenPept UniProtKB/Swiss-Prot:Q8BIJ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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