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Coro6 coronin 6 [ Mus musculus (house mouse) ]

Gene ID: 216961, updated on 2-Nov-2024

Summary

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Official Symbol
Coro6provided by MGI
Official Full Name
coronin 6provided by MGI
Primary source
MGI:MGI:2183448
See related
Ensembl:ENSMUSG00000020836 AllianceGenome:MGI:2183448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration. Is expressed in bladder; heart; intestine; and skeletal muscle. Orthologous to human CORO6 (coronin 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in heart adult (RPKM 120.1), cortex adult (RPKM 32.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Coro6 in Genome Data Viewer
Location:
11 B5; 11 46.58 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77353149..77361310)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77462321..77470484)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene slingshot protein phosphatase 2 Neighboring gene heat shock protein 1, alpha pseudogene Neighboring gene STARR-seq mESC enhancer starr_30053 Neighboring gene 60S ribosomal protein L35-like Neighboring gene VISTA enhancer mm146 Neighboring gene STARR-positive B cell enhancer ABC_E5248 Neighboring gene STARR-seq mESC enhancer starr_30055 Neighboring gene microRNA mir-12181 Neighboring gene ankyrin repeat domain 13b Neighboring gene STARR-seq mESC enhancer starr_30056 Neighboring gene GIT ArfGAP 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton. Chen Y, et al. J Neurosci, 2014 Feb 12. PMID 24523531, Free PMC Article
  2. RBM24 is a major regulator of muscle-specific alternative splicing. Yang J, et al. Dev Cell, 2014 Oct 13. PMID 25313962
  3. Heterozygous loss of Rbm24 in the adult mouse heart increases sarcomere slack length but does not affect function. de Groot NE, et al. Sci Rep, 2020 May 6. PMID 32376900, Free PMC Article
  4. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Kannan M, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078390, Free PMC Article
  5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings demonstrate that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the neuromuscular junction
    Title: Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
coronin-6
Names
clipin E
coronin 6/clipin E type D
coronin, actin binding protein 6
coronin-like protein E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368670.1 → NP_001355599.1  coronin-6 isoform D

    Status: VALIDATED

    Source sequence(s)
    AL607072
    Consensus CDS
    CCDS88194.1
    UniProtKB/TrEMBL
    B9EIZ7
    Related
    ENSMUSP00000056862.6, ENSMUST00000052515.12
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 426
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_139128.2 → NP_624354.1  coronin-6 isoform A

    See identical proteins and their annotated locations for NP_624354.1

    Status: VALIDATED

    Source sequence(s)
    AL607072
    Consensus CDS
    CCDS25077.1
    UniProtKB/Swiss-Prot
    Q3TZ14, Q5F262, Q5F263, Q5F264, Q5F265, Q920M3, Q920M4, Q920M5
    Related
    ENSMUSP00000021190.3, ENSMUST00000021190.9
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 465
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_139129.2 → NP_624355.1  coronin-6 isoform C

    See identical proteins and their annotated locations for NP_624355.1

    Status: VALIDATED

    Source sequence(s)
    AL607072
    Consensus CDS
    CCDS25078.1
    UniProtKB/Swiss-Prot
    Q920M5
    Related
    ENSMUSP00000078703.3, ENSMUST00000079770.3
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 425
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_139130.3 → NP_624356.1  coronin-6 isoform B

    See identical proteins and their annotated locations for NP_624356.1

    Status: VALIDATED

    Source sequence(s)
    AL607072
    Consensus CDS
    CCDS25079.1
    UniProtKB/Swiss-Prot
    Q920M5
    Related
    ENSMUSP00000104028.3, ENSMUST00000108391.9
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 465
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_160865.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL607072

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    77353149..77361310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532940.3 → XP_006533003.1  coronin-6 isoform X1

    See identical proteins and their annotated locations for XP_006533003.1

    UniProtKB/Swiss-Prot
    Q920M5
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 466
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006532938.4 → XP_006533001.1  coronin-6 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 466
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_006532945.4 → XP_006533008.1  coronin-6 isoform X4

    See identical proteins and their annotated locations for XP_006533008.1

    UniProtKB/Swiss-Prot
    Q3TZ14, Q5F262, Q5F263, Q5F264, Q5F265, Q920M3, Q920M4, Q920M5
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 465
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_036156578.1 → XP_036012471.1  coronin-6 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 466
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_006532944.3 → XP_006533007.1  coronin-6 isoform X3

    See identical proteins and their annotated locations for XP_006533007.1

    UniProtKB/Swiss-Prot
    Q920M5
    Related
    ENSMUSP00000099551.2, ENSMUST00000102493.8
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 465
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_017314462.3 → XP_017169951.2  coronin-6 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 466
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_006532941.3 → XP_006533004.1  coronin-6 isoform X1

    See identical proteins and their annotated locations for XP_006533004.1

    UniProtKB/Swiss-Prot
    Q920M5
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 466
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_006532942.3 → XP_006533005.1  coronin-6 isoform X1

    See identical proteins and their annotated locations for XP_006533005.1

    UniProtKB/Swiss-Prot
    Q920M5
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 466
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. XM_017314461.3 → XP_017169950.1  coronin-6 isoform X1

    UniProtKB/Swiss-Prot
    Q920M5
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 466
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  10. XM_006532946.3 → XP_006533009.1  coronin-6 isoform X5

    See identical proteins and their annotated locations for XP_006533009.1

    UniProtKB/TrEMBL
    B9EIZ7
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 426
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  11. XM_006532947.4 → XP_006533010.1  coronin-6 isoform X6

    See identical proteins and their annotated locations for XP_006533010.1

    UniProtKB/Swiss-Prot
    Q920M5
    Conserved Domains (2) summary
    sd00039
    Location:37 → 79
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9 → 425
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_001779955.3 RNA Sequence

  2. XR_388405.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920M5.1 GenPept UniProtKB/Swiss-Prot:Q920M5

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