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Rskr ribosomal protein S6 kinase related [ Mus musculus (house mouse) ]

Gene ID: 216976, updated on 2-Nov-2024

Summary

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Official Symbol
Rskrprovided by MGI
Official Full Name
ribosomal protein S6 kinase relatedprovided by MGI
Primary source
MGI:MGI:2652869
See related
Ensembl:ENSMUSG00000037593 AllianceGenome:MGI:2652869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sgk494
Summary
Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Orthologous to human RSKR (ribosomal protein S6 kinase related). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 4.5), testis adult (RPKM 2.6) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Rskr in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78181580..78187631)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78290712..78296805)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30092 Neighboring gene stromal cell derived factor 2 Neighboring gene small nuclear ribonucleoprotein N pseudogene Neighboring gene bridge-like lipid transfer protein family member 2 Neighboring gene predicted gene 3948 Neighboring gene STARR-positive B cell enhancer ABC_E9832 Neighboring gene sperm associated antigen 5 Neighboring gene aldolase C, fructose-bisphosphate

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase-related protein
Names
sugen kinase 494
NP_001274135.1
NP_001391729.1
NP_001391743.1
NP_001391746.1
NP_001391749.1
NP_001391750.1
NP_001391751.1
NP_001391752.1
NP_001391753.1
NP_001391754.1
NP_001391755.1
XP_006533032.1
XP_006533033.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287206.1 → NP_001274135.1  ribosomal protein S6 kinase-related protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591070, BC059191, BY266382
    Conserved Domains (1) summary
    cl21453
    Location:108 → 352
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001404800.1 → NP_001391729.1  ribosomal protein S6 kinase-related protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591070
    UniProtKB/TrEMBL
    A0A5F8MPD4
    Related
    ENSMUSP00000158919.2, ENSMUST00000238934.2

  3. NM_001404814.1 → NP_001391743.1  ribosomal protein S6 kinase-related protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL591070

  4. NM_001404817.1 → NP_001391746.1  ribosomal protein S6 kinase-related protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591070

  5. NM_001404820.1 → NP_001391749.1  ribosomal protein S6 kinase-related protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL591070

  6. NM_001404821.1 → NP_001391750.1  ribosomal protein S6 kinase-related protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL591070

  7. NM_001404822.1 → NP_001391751.1  ribosomal protein S6 kinase-related protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL591070

  8. NM_001404823.1 → NP_001391752.1  ribosomal protein S6 kinase-related protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL591070

  9. NM_001404824.1 → NP_001391753.1  ribosomal protein S6 kinase-related protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL591070

  10. NM_001404825.1 → NP_001391754.1  ribosomal protein S6 kinase-related protein isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL591070

  11. NM_001404826.1 → NP_001391755.1  ribosomal protein S6 kinase-related protein isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL591070

RNA

  1. NR_175867.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591070

  2. NR_175868.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591070

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78181580..78187631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532969.5 → XP_006533032.1  ribosomal protein S6 kinase-related protein isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:20 → 219
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006532970.5 → XP_006533033.1  ribosomal protein S6 kinase-related protein isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:2 → 171
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_388408.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001045522.1: Suppressed sequence

    Description
    NM_001045522.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SYL1.1 GenPept UniProtKB/Swiss-Prot:Q5SYL1

Gene LinkOut

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