Utp6 UTP6 small subunit processome component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Utp6provided by MGI
Official Full Name: UTP6 small subunit processome componentprovided by MGI
Primary source: MGI:MGI:2445193
See related: Ensembl:ENSMUSG00000035575 AllianceGenome:MGI:2445193
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HCA66; 4732497O03Rik
Summary: Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in chromosome and nucleolus. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in several structures, including brain; branchial arch; future forebrain; heart; and inner ear. Orthologous to human UTP6 (UTP6 small subunit processome component). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 15.0), placenta adult (RPKM 9.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 47.29 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (79824782..79853213, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (79933956..79962387, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that reduced expression of HCA66, owing to haploinsufficiency of HCA66 gene, could render NF1 microdeleted patients-derived cells less susceptible to apoptosis.
Title: Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Utp6 (e-PCR), detects polymorphism
- UniSTS:498259

fe50c07.y1 (e-PCR)
- UniSTS:196579

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables snoRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: U3 small nucleolar RNA-associated protein 6 homolog

Names: UTP6, small subunit (SSU) processome component, homolog; hepatocellular carcinoma-associated antigen 66; multiple hat domains protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144826.3 → NP_659075.1 U3 small nucleolar RNA-associated protein 6 homolog

See identical proteins and their annotated locations for NP_659075.1

Status: PROVISIONAL

Source sequence(s)

AK029151

Consensus CDS

CCDS25124.1

UniProtKB/Swiss-Prot

Q8CH76, Q8VCY6

Related

ENSMUSP00000046643.6, ENSMUST00000043152.6

Conserved Domains (2) summary

COG5191
Location:1 → 222

COG5191; Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat [General function prediction only]

pfam08640
Location:9 → 81

U3_assoc_6; U3 small nucleolar RNA-associated protein 6