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FABP6 fatty acid binding protein 6 [ Homo sapiens (human) ]

Gene ID: 2172, updated on 2-Nov-2024

Summary

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Official Symbol
FABP6provided by HGNC
Official Full Name
fatty acid binding protein 6provided by HGNC
Primary source
HGNC:HGNC:3561
See related
Ensembl:ENSG00000170231 MIM:600422; AllianceGenome:HGNC:3561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILBP; I-15P; I-BAP; ILBP3; ILLBP; I-BABP; I-BALB
Summary
This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward small intestine (RPKM 820.3) See more
Orthologs
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Genomic context

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See FABP6 in Genome Data Viewer
Location:
5q33.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (160187381..160238722)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (160715939..160767284)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159614388..159665729)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901124 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:159455528-159455695 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159469604-159470298 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159470299-159470993 Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159487609-159488120 Neighboring gene PWWP domain containing 2A Neighboring gene MPRA-validated peak5557 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159507098-159508004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159508005-159508910 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:159513521-159513688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23555 Neighboring gene MPRA-validated peak5558 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16575 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159546009-159546508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23557 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159588248-159588903 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159589561-159590215 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159591897-159592496 Neighboring gene Sharpr-MPRA regulatory region 721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:159593698-159594298 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159602660-159603248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16579 Neighboring gene MPRA-validated peak5559 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16580 Neighboring gene FABP6 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16581 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159664401-159665356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23558 Neighboring gene uncharacterized LOC105377691 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene cyclin J like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma. Fang C, et al. Cancer Res, 2007 Oct 1. PMID 17909007
  2. Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. Fujita M, et al. Eur J Biochem, 1995 Oct 15. PMID 7588781
  3. Cloning and chromosomal localization of the human ileal lipid-binding protein. Oelkers P, et al. Biochim Biophys Acta, 1995 Jul 13. PMID 7619861
  4. Immunohistochemical distribution of intestinal 15 kDa protein in human tissues. Watanabe K, et al. Arch Histol Cytol, 1995 Aug. PMID 8527237
  5. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. Kurz M, et al. Proteins, 2003 Feb 1. PMID 12486725

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. REST Promotes Autophagy in Gastric Cancer by Transcriptionally Activating FABP6 to Inhibit the Akt/mTOR Signaling Pathway.
    Title: REST Promotes Autophagy in Gastric Cancer by Transcriptionally Activating FABP6 to Inhibit the Akt/mTOR Signaling Pathway.
  2. Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein.
    Title: Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein.
  3. Fatty Acid Binding Protein 6 Inhibition Decreases Cell Cycle Progression, Migration and Autophagy in Bladder Cancers.
    Title: Fatty Acid Binding Protein 6 Inhibition Decreases Cell Cycle Progression, Migration and Autophagy in Bladder Cancers.
  4. Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells.
    Title: Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells.
  5. Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma.
    Title: Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma.
  6. Functional suppression of FABP7 significantly inhibited SKRC10 clear cell renal cell carcinoma (ccRCC) cells growth and resulted in a significant reduction of the invasive potential but did not cause growth inhibition of SKRC7 cells. Functional suppression of FABP6 resulted in significant growth inhibition of SKRC7 cells. This is the first report about the complementary role of FABP6 for FABP7 in ccRCC.
    Title: Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma.
  7. Experimental analysis showed the importance of LEF1, ETV4 and FABP6 as three co-regulated prognostic markers in patients with colorectal cancer metastasis.
    Title: An integrated study on TFs and miRNAs in colorectal cancer metastasis and evaluation of three co-regulated candidate genes as prognostic markers.
  8. Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR
    Title: Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR.
  9. Analysis of slow and fast motions in I-BABP indicates largely different energy landscapes for the apo and holo states suggesting that optimization of binding interactions might be achieved by altering the dynamic behavior of specific protein segments.
    Title: Temperature dependence of backbone dynamics in human ileal bile acid-binding protein: implications for the mechanism of ligand binding.
  10. show, using electrospray ionization mass spectroscopy, that human ILBP binds bile acids with a 3:1 ratio, even at low protein and ligand concentrations
    Title: Cooperativity and site selectivity in the ileal lipid binding protein.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gastrotropin
Names
GT
fatty acid binding protein 6, ileal
ileal bile acid binding protein
ileal lipid-binding protein
illeal lipid-binding protein
intestinal 15 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029500.1 RefSeqGene

    Range
    47140..56350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040442.1 → NP_001035532.1  gastrotropin isoform 1

    See identical proteins and their annotated locations for NP_001035532.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AI208231, BC022489, X90908
    Consensus CDS
    CCDS43393.1
    UniProtKB/Swiss-Prot
    P51161
    Conserved Domains (1) summary
    pfam14651
    Location:52 → 177
    Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family

  2. NM_001130958.2 → NP_001124430.1  gastrotropin isoform 1

    See identical proteins and their annotated locations for NP_001124430.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional 5' exon, as compared to variant 1. Both variants 1 and 3 encode the same isoform 1.
    Source sequence(s)
    DQ132786
    Consensus CDS
    CCDS43393.1
    UniProtKB/Swiss-Prot
    P51161
    Related
    ENSP00000377549.4, ENST00000393980.8
    Conserved Domains (1) summary
    pfam14651
    Location:52 → 177
    Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family

  3. NM_001445.3 → NP_001436.1  gastrotropin isoform 2

    See identical proteins and their annotated locations for NP_001436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two 5' exons and has an alternate 5' sequence, and the translation initiation starts from a downstream AUG codon, as compared to variant 1. The encoded protein (isoform 2) is dominant and shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    X90908
    Consensus CDS
    CCDS4349.1
    UniProtKB/Swiss-Prot
    P51161, Q07DR7, Q8TBI3, Q9UGI7
    Related
    ENSP00000385433.4, ENST00000402432.4
    Conserved Domains (1) summary
    cl21528
    Location:1 → 128
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    160187381..160238722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    160715939..160767284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51161.2 GenPept UniProtKB/Swiss-Prot:P51161

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