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Atxn7l3 ataxin 7-like 3 [ Mus musculus (house mouse) ]

Gene ID: 217218, updated on 2-Nov-2024

Summary

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Official Symbol
Atxn7l3provided by MGI
Official Full Name
ataxin 7-like 3provided by MGI
Primary source
MGI:MGI:3036270
See related
Ensembl:ENSMUSG00000059995 AllianceGenome:MGI:3036270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E030022H21Rik
Summary
Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of DUBm complex and SAGA complex. Orthologous to human ATXN7L3 (ataxin 7 like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cortex adult (RPKM 32.3), whole brain E14.5 (RPKM 28.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Atxn7l3 in Genome Data Viewer
Location:
11 D; 11 66.29 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102180126..102187615, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102289300..102297045, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E911 Neighboring gene homologous recombination factor with OB-fold Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102128926-102129035 Neighboring gene ankyrin repeat and SOCS box-containing 16 Neighboring gene STARR-positive B cell enhancer ABC_E1432 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102156604-102156807 Neighboring gene transmembrane and ubiquitin-like domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E469 Neighboring gene predicted gene, 33851 Neighboring gene STARR-positive B cell enhancer ABC_E5281 Neighboring gene upstream binding transcription factor, RNA polymerase I Neighboring gene STARR-seq mESC enhancer starr_30800 Neighboring gene solute carrier family 4 (anion exchanger), member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription. Wang F, et al. Cell Death Differ, 2021 Aug. PMID 33731875, Free PMC Article
  2. The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription. Bonnet J, et al. Genes Dev, 2014 Sep 15. PMID 25228644, Free PMC Article
  3. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. Brand M, et al. EMBO J, 2001 Jun 15. PMID 11406595, Free PMC Article
  4. Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Khang R, et al. Sci Rep, 2021 Nov 23. PMID 34815492, Free PMC Article
  5. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. Brand M, et al. J Biol Chem, 1999 Jun 25. PMID 10373431

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC161359

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DUBm complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DUBm complex IEA
Inferred from Electronic Annotation
more info
  
part_of DUBm complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
ataxin-7-like protein 3
Names
SAGA-associated factor 11 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098836.2 → NP_001092306.1  ataxin-7-like protein 3 isoform a

    See identical proteins and their annotated locations for NP_001092306.1

    Status: VALIDATED

    Source sequence(s)
    AL954730
    Consensus CDS
    CCDS48942.1
    UniProtKB/TrEMBL
    Z4YN62
    Related
    ENSMUSP00000102750.3, ENSMUST00000107132.3
    Conserved Domains (2) summary
    pfam08209
    Location:80 → 112
    Sgf11; Sgf11 (transcriptional regulation protein)
    pfam08313
    Location:215 → 244
    SCA7; zinc-binding domain

  2. NM_001098837.2 → NP_001092307.1  ataxin-7-like protein 3 isoform b

    See identical proteins and their annotated locations for NP_001092307.1

    Status: VALIDATED

    Source sequence(s)
    AL954730
    Consensus CDS
    CCDS48941.1
    UniProtKB/Swiss-Prot
    A2AWT2, A2AWT3, A2AWT4, Q8C1T7
    UniProtKB/TrEMBL
    Z4YN62
    Related
    ENSMUSP00000072967.3, ENSMUST00000073234.9
    Conserved Domains (2) summary
    pfam08209
    Location:80 → 112
    Sgf11; Sgf11 (transcriptional regulation protein)
    pfam08313
    Location:208 → 237
    SCA7; zinc-binding domain

  3. NM_001403848.1 → NP_001390777.1  ataxin-7-like protein 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL954730

  4. NM_001403849.1 → NP_001390778.1  ataxin-7-like protein 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL954730
    UniProtKB/Swiss-Prot
    A2AWT2, A2AWT3, A2AWT4, Q8C1T7

  5. NM_001403850.1 → NP_001390779.1  ataxin-7-like protein 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL954730
    UniProtKB/Swiss-Prot
    A2AWT2, A2AWT3, A2AWT4, Q8C1T7

  6. NM_001403852.1 → NP_001390781.1  ataxin-7-like protein 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL954730

  7. NM_001403854.1 → NP_001390783.1  ataxin-7-like protein 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL954730

  8. NM_001403855.1 → NP_001390784.1  ataxin-7-like protein 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL954730

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102180126..102187615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533045.4 → XP_006533108.1  ataxin-7-like protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006533108.1

    Conserved Domains (2) summary
    pfam08209
    Location:80 → 112
    Sgf11; Sgf11 (transcriptional regulation protein)
    pfam08313
    Location:234 → 263
    SCA7; zinc-binding domain

  2. XM_036156595.1 → XP_036012488.1  ataxin-7-like protein 3 isoform X7

    Conserved Domains (1) summary
    pfam08313
    Location:108 → 137
    SCA7; zinc-binding domain

  3. XM_036156592.1 → XP_036012485.1  ataxin-7-like protein 3 isoform X2

    Conserved Domains (2) summary
    pfam08209
    Location:80 → 112
    Sgf11; Sgf11 (transcriptional regulation protein)
    pfam08313
    Location:234 → 263
    SCA7; zinc-binding domain

  4. XM_036156594.1 → XP_036012487.1  ataxin-7-like protein 3 isoform X6

    Related
    ENSMUSP00000121917.2, ENSMUST00000141516.8
    Conserved Domains (1) summary
    pfam08313
    Location:127 → 156
    SCA7; zinc-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AWT3.1 GenPept UniProtKB/Swiss-Prot:A2AWT3

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