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Cdc27 cell division cycle 27 [ Mus musculus (house mouse) ]

Gene ID: 217232, updated on 2-Nov-2024

Summary

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Official Symbol
Cdc27provided by MGI
Official Full Name
cell division cycle 27provided by MGI
Primary source
MGI:MGI:102685
See related
Ensembl:ENSMUSG00000020687 AllianceGenome:MGI:102685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APC3
Summary
Predicted to enable protein phosphatase binding activity. Acts upstream of or within neuron projection development. Predicted to be located in centrosome; mitotic spindle; and nucleoplasm. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Is expressed in brain; cerebellum; cerebral cortex; and head. Orthologous to human CDC27 (cell division cycle 27). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.7), placenta adult (RPKM 12.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Cdc27 in Genome Data Viewer
Location:
11 E1; 11 67.79 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (104393350..104441371, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (104502524..104550620, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein tau Neighboring gene predicted gene, 22743 Neighboring gene STARR-seq mESC enhancer starr_30878 Neighboring gene STARR-seq mESC enhancer starr_30880 Neighboring gene STARR-seq mESC enhancer starr_30882 Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:104286345-104286585 Neighboring gene STARR-seq mESC enhancer starr_30888 Neighboring gene STARR-positive B cell enhancer mm9_chr11:104322909-104323210 Neighboring gene STARR-positive B cell enhancer mm9_chr11:104330691-104330991 Neighboring gene STARR-seq mESC enhancer starr_30889 Neighboring gene STARR-seq mESC enhancer starr_30890 Neighboring gene myosin, light polypeptide 4 Neighboring gene predicted gene 11665 Neighboring gene TROVE domain family, member 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base. Tugendreich S, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 8234252, Free PMC Article
  2. Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. Zur A, et al. EMBO J, 2001 Feb 15. PMID 11179223, Free PMC Article
  3. Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Akhter S, et al. Mol Cell Biol, 2004 Dec. PMID 15542852, Free PMC Article
  4. C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression. Pawar SA, et al. Proc Natl Acad Sci U S A, 2010 May 18. PMID 20439707, Free PMC Article
  5. A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain. Huang J, et al. Neuron, 2015 May 6. PMID 25913861, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cdc27 directs cyclin D1 to alternative degradation by anaphase promoting complex/cyclosome.
    Title: C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein branched polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
part_of anaphase-promoting complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cell division cycle protein 27 homolog
Names
cell division cycle 27 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285988.2 → NP_001272917.1  cell division cycle protein 27 homolog isoform 1

    See identical proteins and their annotated locations for NP_001272917.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL603709
    UniProtKB/Swiss-Prot
    A2A6Q5
    Conserved Domains (5) summary
    COG0457
    Location:507 → 768
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:573 → 601
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:641 → 673
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:17 → 92
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13181
    Location:745 → 775
    TPR_8; Tetratricopeptide repeat

  2. NM_001285989.2 → NP_001272918.1  cell division cycle protein 27 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AL603709
    UniProtKB/TrEMBL
    Q3TTW1
    Conserved Domains (5) summary
    COG0457
    Location:501 → 762
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:567 → 595
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:635 → 667
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:17 → 92
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13181
    Location:739 → 769
    TPR_8; Tetratricopeptide repeat

  3. NM_001285990.2 → NP_001272919.1  cell division cycle protein 27 homolog isoform 4

    See identical proteins and their annotated locations for NP_001272919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AL603709
    Conserved Domains (5) summary
    COG0457
    Location:373 → 634
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:439 → 467
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:507 → 539
    TPR_1; Tetratricopeptide repeat
    pfam13181
    Location:611 → 641
    TPR_8; Tetratricopeptide repeat
    pfam13424
    Location:329 → 400
    TPR_12; Tetratricopeptide repeat

  4. NM_145436.3 → NP_663411.2  cell division cycle protein 27 homolog isoform 2

    See identical proteins and their annotated locations for NP_663411.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL603709
    Consensus CDS
    CCDS36354.1
    UniProtKB/Swiss-Prot
    A2A6Q5, A2A6Q6, B2RXS0
    Related
    ENSMUSP00000091452.3, ENSMUST00000093923.9
    Conserved Domains (5) summary
    COG0457
    Location:502 → 763
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:568 → 596
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:636 → 668
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:17 → 92
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13181
    Location:740 → 770
    TPR_8; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    104393350..104441371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156600.1 → XP_036012493.1  cell division cycle protein 27 homolog isoform X4

    Conserved Domains (2) summary
    COG0457
    Location:405 → 666
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:471 → 499
    TPR; TPR repeat [structural motif]

  2. XM_036156599.1 → XP_036012492.1  cell division cycle protein 27 homolog isoform X3

    Conserved Domains (2) summary
    COG0457
    Location:441 → 702
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:507 → 535
    TPR; TPR repeat [structural motif]

  3. XM_036156597.1 → XP_036012490.1  cell division cycle protein 27 homolog isoform X2

    Conserved Domains (2) summary
    COG0457
    Location:179 → 440
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245 → 273
    TPR; TPR repeat [structural motif]

  4. XM_036156596.1 → XP_036012489.1  cell division cycle protein 27 homolog isoform X2

    Conserved Domains (2) summary
    COG0457
    Location:179 → 440
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245 → 273
    TPR; TPR repeat [structural motif]

  5. XM_006533052.5 → XP_006533115.1  cell division cycle protein 27 homolog isoform X2

    See identical proteins and their annotated locations for XP_006533115.1

    Conserved Domains (2) summary
    COG0457
    Location:179 → 440
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245 → 273
    TPR; TPR repeat [structural motif]

  6. XM_036156598.1 → XP_036012491.1  cell division cycle protein 27 homolog isoform X2

    Conserved Domains (2) summary
    COG0457
    Location:179 → 440
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245 → 273
    TPR; TPR repeat [structural motif]

  7. XM_006533050.4 → XP_006533113.1  cell division cycle protein 27 homolog isoform X1

    UniProtKB/Swiss-Prot
    A2A6Q5
    Related
    ENSMUSP00000102575.3, ENSMUST00000106962.9
    Conserved Domains (3) summary
    COG0457
    Location:508 → 769
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:574 → 602
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:17 → 92
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

  8. XM_036156601.1 → XP_036012494.1  cell division cycle protein 27 homolog isoform X5

    Conserved Domains (2) summary
    COG0457
    Location:441 → 701
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:507 → 535
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A6Q5.1 GenPept UniProtKB/Swiss-Prot:A2A6Q5

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