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Tesk1 testis specific protein kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 21754, updated on 2-Nov-2024

Summary

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Official Symbol
Tesk1provided by MGI
Official Full Name
testis specific protein kinase 1provided by MGI
Primary source
MGI:MGI:1201675
See related
Ensembl:ENSMUSG00000028458 AllianceGenome:MGI:1201675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein kinase binding activity and protein serine/threonine kinase activity. Involved in nuclear-transcribed mRNA catabolic process, no-go decay; podocyte cell migration; and regulation of actin cytoskeleton organization. Predicted to be located in centrosome; cytoplasmic vesicle; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in cochlea and tooth. Orthologous to human TESK1 (testis associated actin remodelling kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 319.6), adrenal adult (RPKM 38.4) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Tesk1 in Genome Data Viewer
Location:
4 A5; 4 23.04 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43442277..43448075)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43442277..43448075)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RUN and SH3 domain containing 2 Neighboring gene predicted gene, 52698 Neighboring gene STARR-seq mESC enhancer starr_10053 Neighboring gene ciliary microtubule inner protein 2B Neighboring gene CD72 antigen Neighboring gene STARR-positive B cell enhancer ABC_E2109 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:43495064-43495217 Neighboring gene STARR-positive B cell enhancer ABC_E834 Neighboring gene suppression inducing transmembrane adaptor 1 Neighboring gene RNA component of mitochondrial RNAase P

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cell-type-specific expression of a TESK1 promoter-linked lacZ gene in transgenic mice. Toshima J, et al. Biochem Biophys Res Commun, 2001 Aug 24. PMID 11511097
  2. Structural organization and chromosomal localization of the mouse tesk1 (testis-specific protein kinase 1) gene. Toshima J, et al. Gene, 1998 Jan 12. PMID 9469938
  3. Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1). Wang L, et al. Sci Rep, 2018 Aug 16. PMID 30115939, Free PMC Article
  4. Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations. Morita R, et al. PLoS One, 2016. PMID 27588418, Free PMC Article
  5. Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Fang Q, et al. Sci Rep, 2019 Mar 4. PMID 30833597, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of vesicle localization ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of vesicle localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, no-go decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in podocyte cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of stress fiber assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dual specificity testis-specific protein kinase 1
Names
testicular protein kinase 1
NP_035701.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011571.3 → NP_035701.3  dual specificity testis-specific protein kinase 1

    See identical proteins and their annotated locations for NP_035701.3

    Status: VALIDATED

    Source sequence(s)
    AK144302, BB325506, BC099699
    Consensus CDS
    CCDS18094.1
    UniProtKB/Swiss-Prot
    O70146, O70147, Q499W7
    Related
    ENSMUSP00000050087.7, ENSMUST00000060864.13
    Conserved Domains (2) summary
    smart00219
    Location:56 → 306
    TyrKc; Tyrosine kinase, catalytic domain
    cd14155
    Location:58 → 312
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43442277..43448075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70146.3 GenPept UniProtKB/Swiss-Prot:O70146

Gene LinkOut

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