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Plekhd1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 [ Mus musculus (house mouse) ]

Gene ID: 217682, updated on 2-Nov-2024

Summary

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Official Symbol
Plekhd1provided by MGI
Official Full Name
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1provided by MGI
Primary source
MGI:MGI:3036228
See related
Ensembl:ENSMUSG00000066438 AllianceGenome:MGI:3036228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3830431G21Rik
Summary
Is expressed in dorsal root ganglion; midbrain mantle layer; rest of cerebellum mantle layer; and trigeminal ganglion. Orthologous to human PLEKHD1 (pleckstrin homology and coiled-coil domain containing D1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 11.3), placenta adult (RPKM 7.7) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Plekhd1 in Genome Data Viewer
Location:
12 C3; 12 36.96 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80739375..80770990)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80692601..80724216)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4032 Neighboring gene solute carrier family 39 (zinc transporter), member 9 Neighboring gene ERH mRNA splicing and mitosis factor Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1, opposite strand Neighboring gene predicted gene, 51986 Neighboring gene STARR-seq mESC enhancer starr_32646 Neighboring gene coiled-coil domain containing 177 Neighboring gene STARR-seq mESC enhancer starr_32647 Neighboring gene STARR-seq mESC enhancer starr_32648 Neighboring gene sushi domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_32649 Neighboring gene STARR-positive B cell enhancer ABC_E5337 Neighboring gene STARR-seq mESC enhancer starr_32653

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family D member 1
Names
PH domain-containing family D member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177503.1 → NP_001170974.1  pleckstrin homology domain-containing family D member 1

    See identical proteins and their annotated locations for NP_001170974.1

    Status: VALIDATED

    Source sequence(s)
    AC134537, AI747346, AK028383, CF353072
    Consensus CDS
    CCDS49100.1
    UniProtKB/Swiss-Prot
    B2RPU2
    Related
    ENSMUSP00000119711.2, ENSMUST00000140770.2
    Conserved Domains (3) summary
    cd13281
    Location:18 → 156
    PH_PLEKHD1; Pleckstrin homology (PH) domain containing, family D (with coiled-coil domains) member 1 PH domain
    pfam00169
    Location:29 → 134
    PH; PH domain
    pfam09798
    Location:168 → 285
    LCD1; DNA damage checkpoint protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    80739375..80770990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515683.5 → XP_006515746.1  pleckstrin homology domain-containing family D member 1 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:146 → 392
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13281
    Location:18 → 156
    PH_PLEKHD1; Pleckstrin homology (PH) domain containing, family D (with coiled-coil domains) member 1 PH domain

  2. XM_036157310.1 → XP_036013203.1  pleckstrin homology domain-containing family D member 1 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:117 → 363
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl17171
    Location:22 → 127
    PH-like; Pleckstrin homology-like domain

  3. XM_011244059.1 → XP_011242361.1  pleckstrin homology domain-containing family D member 1 isoform X1

    See identical proteins and their annotated locations for XP_011242361.1

    Conserved Domains (2) summary
    COG1196
    Location:117 → 363
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl17171
    Location:22 → 127
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RPU2.1 GenPept UniProtKB/Swiss-Prot:B2RPU2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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