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Tfdp1 transcription factor Dp 1 [ Mus musculus (house mouse) ]

Gene ID: 21781, updated on 2-Nov-2024

Summary

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Official Symbol
Tfdp1provided by MGI
Official Full Name
transcription factor Dp 1provided by MGI
Primary source
MGI:MGI:101934
See related
Ensembl:ENSMUSG00000038482 AllianceGenome:MGI:101934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dp1; Drtf1
Summary
Enables DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of fat cell proliferation. Acts upstream of or within anoikis; epidermis development; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in mismatch repair cancer syndrome. Orthologous to several human genes including TFDP1 (transcription factor Dp-1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 53.8), liver E14 (RPKM 51.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tfdp1 in Genome Data Viewer
Location:
8 A1.1; 8 5.78 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13388273..13428448)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13338725..13378448)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene predicted gene, 25014 Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene STARR-positive B cell enhancer ABC_E6621 Neighboring gene ATPase, H+/K+ exchanging, beta polypeptide Neighboring gene G protein-coupled receptor kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of protein phosphatase 2A expression correlates with phosphorylation of DP-1 and reversal of dysplasia through differentiation in a conditional mouse model of cancer progression. Tilli MT, et al. Cancer Res, 2003 Nov 15. PMID 14633688
  2. Deregulated expression of DP1 induces epidermal proliferation and enhances skin carcinogenesis. Wang D, et al. Mol Carcinog, 2001 Jun. PMID 11429786
  3. A new component of the transcription factor DRTF1/E2F. Girling R, et al. Nature, 1993 Mar 4. PMID 8446173
  4. Modulation of E2F activity is linked to interferon-induced growth suppression of hematopoietic cells. Iwase S, et al. J Biol Chem, 1997 May 9. PMID 9139687
  5. In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis. Tran NT, et al. Leukemia, 2024 Sep. PMID 39043964, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
    Title: In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
  2. Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.
    Title: Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.
  3. KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.
    Title: KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.
  4. Kbtbd5 regulates skeletal muscle myogenesis through the regulation of E2F1-DP1 activity
    Title: Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.
  5. Cell cycle suppression by Cdk5 is made through the formation of a previously unknown complex consisting of the p35-Cdk5 dimer and E2F1, which excludes the E2F1 cofactor, DP1, thus inhibiting E2F1 binding to the promoters of various cell cycle genes.
    Title: Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex.
  6. Persistent PP2A expression prevented the appearance of the phosphorylated form of DP-1 required for cellular differentiation and reversal of dysplasia after loss of oncogene expression.
    Title: Loss of protein phosphatase 2A expression correlates with phosphorylation of DP-1 and reversal of dysplasia through differentiation in a conditional mouse model of cancer progression.
  7. Results show that Dp1 is largely dispensable for embryonic development, despite the absolute extraembryonic requirement for Dp1.
    Title: Dp1 is largely dispensable for embryonic development.
  8. Absolutely required for extra-embryonic development and consequently embryonic survival.
    Title: Dp1 is required for extra-embryonic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anoikis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Rb-E2F complex ISO
Inferred from Sequence Orthology
more info
  
part_of Rb-E2F complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor Dp-1
Names
DRTF1-polypeptide 1
E2F dimerization partner 1
cell cycle regulatory transcription factor DP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291765.2 → NP_001278694.1  transcription factor Dp-1 isoform 1

    See identical proteins and their annotated locations for NP_001278694.1

    Status: VALIDATED

    Source sequence(s)
    AC130818
    Consensus CDS
    CCDS22110.1
    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3, Q9D297
    Related
    ENSMUSP00000147881.2, ENSMUST00000209885.2
    Conserved Domains (3) summary
    cd14458
    Location:198 → 244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:112 → 193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200 → 338
    DP; Transcription factor DP

  2. NM_001291766.2 → NP_001278695.1  transcription factor Dp-1 isoform 2

    See identical proteins and their annotated locations for NP_001278695.1

    Status: VALIDATED

    Source sequence(s)
    AC130818
    Consensus CDS
    CCDS85506.1
    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78 → 124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:1 → 73
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80 → 218
    DP; Transcription factor DP

  3. NM_001291768.2 → NP_001278697.1  transcription factor Dp-1 isoform 2

    See identical proteins and their annotated locations for NP_001278697.1

    Status: VALIDATED

    Source sequence(s)
    AC130818
    Consensus CDS
    CCDS85506.1
    UniProtKB/TrEMBL
    Q9CYZ7
    Related
    ENSMUSP00000147662.2, ENSMUST00000209396.2
    Conserved Domains (3) summary
    cd14458
    Location:78 → 124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:1 → 73
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80 → 218
    DP; Transcription factor DP

  4. NM_001358991.2 → NP_001345920.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    Consensus CDS
    CCDS85506.1
    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78 → 124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:1 → 73
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80 → 218
    DP; Transcription factor DP

  5. NM_001413797.1 → NP_001400726.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  6. NM_001413798.1 → NP_001400727.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  7. NM_001413799.1 → NP_001400728.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  8. NM_001413800.1 → NP_001400729.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  9. NM_001413801.1 → NP_001400730.1  transcription factor Dp-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC130818

  10. NM_001413802.1 → NP_001400731.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  11. NM_001413803.1 → NP_001400732.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  12. NM_001413804.1 → NP_001400733.1  transcription factor Dp-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC130818

  13. NM_001413805.1 → NP_001400734.1  transcription factor Dp-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC130818

  14. NM_001413806.1 → NP_001400735.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  15. NM_001413807.1 → NP_001400736.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  16. NM_001413808.1 → NP_001400737.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  17. NM_001413809.1 → NP_001400738.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  18. NM_001413810.1 → NP_001400739.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  19. NM_001413811.1 → NP_001400740.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  20. NM_001413812.1 → NP_001400741.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  21. NM_001413813.1 → NP_001400742.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  22. NM_001413814.1 → NP_001400743.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  23. NM_001413815.1 → NP_001400744.1  transcription factor Dp-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC130818

  24. NM_001413816.1 → NP_001400745.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  25. NM_001413817.1 → NP_001400746.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  26. NM_001413818.1 → NP_001400747.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  27. NM_001413819.1 → NP_001400748.1  transcription factor Dp-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3

  28. NM_001413820.1 → NP_001400749.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  29. NM_001413821.1 → NP_001400750.1  transcription factor Dp-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/TrEMBL
    Q9CYZ7

  30. NM_001413822.1 → NP_001400751.1  transcription factor Dp-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3

  31. NM_001413823.1 → NP_001400752.1  transcription factor Dp-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC130818
    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3

  32. NM_009361.4 → NP_033387.1  transcription factor Dp-1 isoform 1

    See identical proteins and their annotated locations for NP_033387.1

    Status: VALIDATED

    Source sequence(s)
    AC130818
    Consensus CDS
    CCDS22110.1
    UniProtKB/Swiss-Prot
    Q08639
    UniProtKB/TrEMBL
    Q3V3X3, Q9D297
    Related
    ENSMUST00000211606.2
    Conserved Domains (3) summary
    cd14458
    Location:198 → 244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:112 → 193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200 → 338
    DP; Transcription factor DP

RNA

  1. NR_182219.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130818

  2. NR_182220.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130818
    Related
    ENSMUST00000210501.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13388273..13428448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312657.3 → XP_017168146.1  transcription factor Dp-1 isoform X1

    UniProtKB/TrEMBL
    Q9D297
    Conserved Domains (3) summary
    cd14458
    Location:200 → 246
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:115 → 195
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:202 → 340
    DP; Transcription factor DP

  2. XM_036153872.1 → XP_036009765.1  transcription factor Dp-1 isoform X1

    UniProtKB/TrEMBL
    Q9D297
    Conserved Domains (3) summary
    cd14458
    Location:200 → 246
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:115 → 195
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:202 → 340
    DP; Transcription factor DP

  3. XM_017312659.3 → XP_017168148.1  transcription factor Dp-1 isoform X1

    UniProtKB/TrEMBL
    Q9D297
    Conserved Domains (3) summary
    cd14458
    Location:200 → 246
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:115 → 195
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:202 → 340
    DP; Transcription factor DP

  4. XM_036153874.1 → XP_036009767.1  transcription factor Dp-1 isoform X3

    UniProtKB/TrEMBL
    Q9CYZ7
    Conserved Domains (3) summary
    cd14458
    Location:78 → 124
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:1 → 73
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:80 → 218
    DP; Transcription factor DP

  5. XM_017312658.3 → XP_017168147.1  transcription factor Dp-1 isoform X1

    UniProtKB/TrEMBL
    Q9D297
    Conserved Domains (3) summary
    cd14458
    Location:200 → 246
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:115 → 195
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:202 → 340
    DP; Transcription factor DP
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08639.1 GenPept UniProtKB/Swiss-Prot:Q08639

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