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Ifi27l2b interferon, alpha-inducible protein 27 like 2B [ Mus musculus (house mouse) ]

Gene ID: 217845, updated on 2-Nov-2024

Summary

Official Symbol
Ifi27l2bprovided by MGI
Official Full Name
interferon, alpha-inducible protein 27 like 2Bprovided by MGI
Primary source
MGI:MGI:1916390
See related
Ensembl:ENSMUSG00000021208 AllianceGenome:MGI:1916390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ISG12(b2); 1810023F06Rik
Summary
Enables identical protein binding activity. Involved in intrinsic apoptotic signaling pathway. Located in mitochondrial inner membrane. Orthologous to several human genes including IFI27L2 (interferon alpha inducible protein 27 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in duodenum adult (RPKM 471.2), small intestine adult (RPKM 461.9) and 3 other tissues See more
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Genomic context

See Ifi27l2b in Genome Data Viewer
Location:
12 E; 12 52.93 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103417157..103423482, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103450898..103457223, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene predicted gene, 53758 Neighboring gene STARR-positive B cell enhancer ABC_E2394 Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene interferon, alpha-inducible protein 27 Neighboring gene predicted gene, 53759 Neighboring gene STARR-positive B cell enhancer ABC_E7175 Neighboring gene protein phosphatase 4, regulatory subunit 4 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of cytochrome c from mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon alpha-inducible protein 27-like protein 2B
Names
interferon stimulated gene 12(b2)
interferon-stimulated gene 12 protein B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145449.2NP_663424.1  interferon alpha-inducible protein 27-like protein 2B precursor

    See identical proteins and their annotated locations for NP_663424.1

    Status: VALIDATED

    Source sequence(s)
    AC154347, AK007590, BN000232
    Consensus CDS
    CCDS26133.1
    UniProtKB/Swiss-Prot
    Q6IEB6, Q8VC49
    Related
    ENSMUSP00000041712.7, ENSMUST00000044687.7
    Conserved Domains (1) summary
    pfam06140
    Location:1288
    Ifi-6-16; Interferon-induced 6-16 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    103417157..103423482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515758.2XP_006515821.1  interferon alpha-inducible protein 27-like protein 2B isoform X1

    Conserved Domains (1) summary
    pfam06140
    Location:1279
    Ifi-6-16; Interferon-induced 6-16 family