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Tfpi2 tissue factor pathway inhibitor 2 [ Mus musculus (house mouse) ]

Gene ID: 21789, updated on 2-Nov-2024

Summary

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Official Symbol
Tfpi2provided by MGI
Official Full Name
tissue factor pathway inhibitor 2provided by MGI
Primary source
MGI:MGI:108543
See related
Ensembl:ENSMUSG00000029664 AllianceGenome:MGI:108543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PP5/TFPI-2
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in blood coagulation; cellular response to fluid shear stress; and negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; liver; lung; small intestine; and spleen. Human ortholog(s) of this gene implicated in acute myeloid leukemia and retinal degeneration. Orthologous to human TFPI2 (tissue factor pathway inhibitor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E18 (RPKM 13.4), placenta adult (RPKM 12.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Tfpi2 in Genome Data Viewer
Location:
6 A1; 6 1.81 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (3962589..3988977, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (3962589..3988978, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene calcitonin receptor Neighboring gene predicted gene, 33576 Neighboring gene STARR-seq mESC enhancer starr_15003 Neighboring gene STARR-seq mESC enhancer starr_15005 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_15006 Neighboring gene guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 Neighboring gene guanine nucleotide binding protein (G protein), gamma 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel serine/threonine protein phosphatase type 5 from Trypanosoma brucei. Chaudhuri M. Gene, 2001 Mar 21. PMID 11290414
  2. Nucleotide sequence of the gene encoding murine tissue factor pathway inhibitor-2. Kazama Y, et al. Thromb Haemost, 2000 Jan. PMID 10669168
  3. Dynamic changes of tissue factor pathway inhibitor type 2 associated with IL-1beta and TNF-alpha in the development of murine acute lung injury. Li Z, et al. Thromb Res, 2008. PMID 18499235
  4. Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice. Hong J, et al. Thromb Res, 2016 Jan. PMID 26603320
  5. Over-expression of TFPI-2 promotes atherosclerotic plaque stability by inhibiting MMPs in apoE-/- mice. Pan J, et al. Int J Cardiol, 2013 Sep 30. PMID 23608390

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Restoration of TFPI2 by LSD1 inhibition suppresses tumor progression and potentiates antitumor immunity in breast cancer.
    Title: Restoration of TFPI2 by LSD1 inhibition suppresses tumor progression and potentiates antitumor immunity in breast cancer.
  2. TFPI2 suppresses the interaction of TGF-beta2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
    Title: TFPI2 suppresses the interaction of TGF-β2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
  3. TFPI-2 Protects Against Gram-Negative Bacterial Infection.
    Title: TFPI-2 Protects Against Gram-Negative Bacterial Infection.
  4. Tissue factor pathway Inhibitor 2 potencies differ between antifibrinolytic agents against human and mouse enzymes plasmin, factor XIa, and kallikrein
    Title: S2'-subsite variations between human and mouse enzymes (plasmin, factor XIa, kallikrein) elucidate inhibition differences by tissue factor pathway inhibitor -2 domain1-wild-type, Leu17Arg-mutant and aprotinin.
  5. A novel mouse model is presented and can be used to investigate the role of TFPI-2 in the process of atherosclerosis.
    Title: Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice.
  6. Over-expression of TFPI-2 promotes atherosclerotic plaque stability, which may be related to inhibition of matrix metalloproteinases.
    Title: Over-expression of TFPI-2 promotes atherosclerotic plaque stability by inhibiting MMPs in apoE-/- mice.
  7. Dynamic changes of Tfpi2 associated with Il-1beta and Tnf-alpha in the development of acute lung injury are reported.
    Title: Dynamic changes of tissue factor pathway inhibitor type 2 associated with IL-1beta and TNF-alpha in the development of murine acute lung injury.
  8. Deficiency for the histone methyltransferase EHMT2 or for the Polycomb group protein EED, leads to biallelic expression of Tfpi2 in the extra-embryonic lineages, whereas the other genes in the cluster maintain correct imprinting.
    Title: Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.
  9. Bovine TFPI2 was compared to mouse TFPI2.
    Title: Molecular cloning, expression, and characterization of bovine tissue factor pathway inhibitor-2.
  10. Our data suggest that TFPI-2 may be an important regulator of aberrant angiogenesis associated with tumor growth/metastasis, cardiovascular diseases, chronic inflammation, or diabetes.
    Title: Adenovirus-mediated expression of tissue factor pathway inhibitor-2 inhibits endothelial cell migration and angiogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to fluid shear stress IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tissue factor pathway inhibitor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381907.1 → NP_001368836.1  tissue factor pathway inhibitor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022235
    Conserved Domains (2) summary
    cd00109
    Location:30 → 83
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:151 → 203
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  2. NM_001381908.1 → NP_001368837.1  tissue factor pathway inhibitor 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022235
    Conserved Domains (2) summary
    cd00109
    Location:70 → 123
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:191 → 243
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  3. NM_009364.4 → NP_033390.1  tissue factor pathway inhibitor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AK132268, BU755117
    Consensus CDS
    CCDS19892.1
    UniProtKB/Swiss-Prot
    O35536
    UniProtKB/TrEMBL
    Q3V1S9
    Related
    ENSMUSP00000031674.8, ENSMUST00000031674.11
    Conserved Domains (2) summary
    cd00109
    Location:34 → 87
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:155 → 206
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

RNA

  1. NR_138566.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' terminal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq criteria.
    Source sequence(s)
    AC022235

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    3962589..3988977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241056.3 → XP_011239358.1  tissue factor pathway inhibitor 2 isoform X2

    Conserved Domains (1) summary
    pfam00014
    Location:90 → 141
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  2. XM_011241055.4 → XP_011239357.1  tissue factor pathway inhibitor 2 isoform X1

    See identical proteins and their annotated locations for XP_011239357.1

    UniProtKB/Swiss-Prot
    O35536
    UniProtKB/TrEMBL
    Q3V1S9
    Conserved Domains (2) summary
    cd00109
    Location:34 → 87
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:155 → 206
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35536.1 GenPept UniProtKB/Swiss-Prot:O35536

Gene LinkOut

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