U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 [ Mus musculus (house mouse) ]

Gene ID: 217944, updated on 30-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Rapgef5provided by MGI
Official Full Name
Rap guanine nucleotide exchange factor (GEF) 5provided by MGI
Primary source
MGI:MGI:2444365
See related
Ensembl:ENSMUSG00000041992 AllianceGenome:MGI:2444365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GFR; Mrgef; mmr-gef; mKIAA0277; 4932413M22; D030051B22Rik
Summary
Predicted to enable GTP-dependent protein binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to be located in nuclear body. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart and pericardium; and sensory organ. Orthologous to human RAPGEF5 (Rap guanine nucleotide exchange factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 12.6), cortex adult (RPKM 11.5) and 23 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rapgef5 in Genome Data Viewer
Location:
12 F2; 12 63.06 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (117480146..117723472)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (117516526..117759737)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:118623787-118624087 Neighboring gene predicted gene, 39559 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:118685906-118686089 Neighboring gene predicted gene, 31482 Neighboring gene STARR-positive B cell enhancer ABC_E4048 Neighboring gene STARR-seq mESC enhancer starr_33424 Neighboring gene STARR-seq mESC enhancer starr_33425 Neighboring gene predicted gene, 53774 Neighboring gene STARR-positive B cell enhancer mm9_chr12:119003289-119003590 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:119058566-119058867 Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene cell division cycle associated 7 like Neighboring gene dynein, axonemal, heavy chain 11

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression of the guanine nucleotide exchange factor, RAPGEF5, during mouse and human embryogenesis. Alharatani R, et al. Gene Expr Patterns, 2019 Dec. PMID 31163262
  2. Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder. Bithell A, et al. PLoS One, 2010 Apr 28. PMID 20436929, Free PMC Article
  3. Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants. Codner GF, et al. BMC Biol, 2018 Jun 21. PMID 29925374, Free PMC Article
  4. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Bithell A, et al. Brain Res Dev Brain Res, 2003 Dec 19. PMID 14643017
  5. Dlx transcription factors promote migration through repression of axon and dendrite growth. Cobos I, et al. Neuron, 2007 Jun 21. PMID 17582329, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rap guanine nucleotide exchange factor 5
Names
M-Ras-regulated Rap GEF
MR-GEF
Mras regulated guanine nucleotide exchange factor
guanine nucleotide exchange factor for Rap1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373989.1 → NP_001360918.1  rap guanine nucleotide exchange factor 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC139993, AC163283, AC163286
    Conserved Domains (3) summary
    smart00147
    Location:639 → 878
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:367 → 498
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:98 → 221
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

  2. NM_175930.6 → NP_787126.3  rap guanine nucleotide exchange factor 5 isoform 2

    See identical proteins and their annotated locations for NP_787126.3

    Status: VALIDATED

    Source sequence(s)
    AC139993, AC163283, AC163286
    Consensus CDS
    CCDS36577.1
    UniProtKB/Swiss-Prot
    Q8BJJ9, Q8C0Q9, Q8C0R5
    Related
    ENSMUSP00000105313.3, ENSMUST00000109691.4
    Conserved Domains (3) summary
    smart00147
    Location:574 → 813
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:302 → 433
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:33 → 156
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    117480146..117723472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157373.1 → XP_036013266.1  rap guanine nucleotide exchange factor 5 isoform X2

    Conserved Domains (2) summary
    smart00229
    Location:410 → 514
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:141 → 264
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

  2. XM_030246682.2 → XP_030102542.1  rap guanine nucleotide exchange factor 5 isoform X1

    Conserved Domains (3) summary
    smart00147
    Location:598 → 837
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:326 → 457
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:57 → 180
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0Q9.2 GenPept UniProtKB/Swiss-Prot:Q8C0Q9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools