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Tgfa transforming growth factor alpha [ Mus musculus (house mouse) ]

Gene ID: 21802, updated on 2-Nov-2024

Summary

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Official Symbol
Tgfaprovided by MGI
Official Full Name
transforming growth factor alphaprovided by MGI
Primary source
MGI:MGI:98724
See related
Ensembl:ENSMUSG00000029999 AllianceGenome:MGI:98724
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
wa1; wa-1
Summary
This gene encodes a member of the epidermal growth factor (EGF) family of proteins that regulate cellular proliferation. The encoded protein undergoes proteolytic processing to generate a soluble glycoprotein that is secreted by the cell. The secreted protein binds to the EGF receptors to initiate signaling events resulting in cellular proliferation, mucous production or inhibition of gastric acid secretion. The transgenic expression of the encoded protein in mice induces the development of cancers in various tissues such as liver, pancreas, skin and mammary glands. Mice lacking the encoded protein exhibit a wavy coat and curly whiskers phenotype as well as abnormalities in the eye. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in ovary adult (RPKM 6.7), CNS E18 (RPKM 6.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Tgfa in Genome Data Viewer
Location:
6 D1; 6 37.62 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86172020..86252726)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86195038..86275744)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene adducin 2 Neighboring gene predicted gene, 19596 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene 40S ribosomal protein S28 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effect of alpha-tocopherol on hepatocarcinogenesis in transforming growth factor-alpha (TGF-alpha) transgenic mice treated with diethylnitrosamine. Kakizaki S, et al. Int J Vitam Nutr Res, 2001 Sep. PMID 11725690
  2. Liver regeneration and hepatocarcinogenesis in transforming growth factor-alpha-targeted mice. Russell WE, et al. Mol Carcinog, 1996 Mar. PMID 8597531
  3. Analysis of the ability of 12-O-tetradecanoylphorbol-13-acetate to induce epidermal hyperplasia, transforming growth factor-alpha, and skin tumor promotion in wa-1 mice. Kiguchi K, et al. J Invest Dermatol, 1997 May. PMID 9129233
  4. Integration of HTLV-1 provirus into mouse transforming growth factor-alpha gene. Fang J, et al. Biochem Biophys Res Commun, 1997 Apr 28. PMID 9168935
  5. Mice lacking transforming growth factor alpha have an increased susceptibility to dextran sulfate-induced colitis. Egger B, et al. Gastroenterology, 1997 Sep. PMID 9287974

See all (243) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Excess Transforming Growth Factor-alpha Changed the Cell Properties of Corneal Epithelium and Stroma.
    Title: Excess Transforming Growth Factor-α Changed the Cell Properties of Corneal Epithelium and Stroma.
  2. TGFalpha preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia.
    Title: TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia.
  3. Tgfa null mice are equally susceptible to spontaneous osteoarthritis development during aging.
    Title: Context-specific protection of TGFα null mice from osteoarthritis.
  4. Here the authors show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes trafficking of several membrane proteins, including the EGFR ligand TGFalpha, from the endoplasmic reticulum (ER) to the Golgi apparatus, thereby triggering their secretion by extracellular microvesicles.
    Title: Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα.
  5. TGF-alpha contributes to the progression of diabetic kidney disease.
    Title: Role of TGF-alpha in the progression of diabetic kidney disease.
  6. Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFalpha in eyelid stroma.
    Title: Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma.
  7. c-Myc and transforming growth factor alpha enhance the development of hepatic lesions due to mutant beta-catenin in transgenic mice.
    Title: c-Myc and transforming growth factor α enhance the development of hepatic lesions due to mutant β-catenin in transgenic mice.
  8. Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments.
    Title: FGF7 signals are relayed to autocrine EGF family growth factors to induce branching morphogenesis of mouse salivary epithelium.
  9. findings suggest that elevated PHD4 levels disturb the angiogenic balance in osteosarcoma via induction of the TGF-alpha pathway and inhibit tumor growth by reducing the expression of HIF-2alpha
    Title: PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.
  10. Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.
    Title: Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Spontaneous (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables epidermal growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
  
enables growth factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERBB2-EGFR signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in hepatocyte proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mammary gland alveolus development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protransforming growth factor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403118.1 → NP_001390047.1  protransforming growth factor alpha isoform 2 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC159549

  2. NM_031199.5 → NP_112476.1  protransforming growth factor alpha isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_112476.1

    Status: REVIEWED

    Source sequence(s)
    AC159549
    Consensus CDS
    CCDS51832.1
    UniProtKB/Swiss-Prot
    P48030
    UniProtKB/TrEMBL
    Q545E4
    Related
    ENSMUSP00000032066.10, ENSMUST00000032066.13
    Conserved Domains (2) summary
    PHA02887
    Location:43 → 82
    PHA02887; EGF-like protein; Provisional
    PHA03099
    Location:46 → 120
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    86172020..86252726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255312.1 → XP_030111172.1  protransforming growth factor alpha isoform X1

    Conserved Domains (2) summary
    PHA02887
    Location:43 → 82
    PHA02887; EGF-like protein; Provisional
    PHA03099
    Location:46 → 120
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48030.1 GenPept UniProtKB/Swiss-Prot:P48030

Gene LinkOut

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