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Slc17a2 solute carrier family 17 (sodium phosphate), member 2 [ Mus musculus (house mouse) ]

Gene ID: 218103, updated on 2-Nov-2024

Summary

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Official Symbol
Slc17a2provided by MGI
Official Full Name
solute carrier family 17 (sodium phosphate), member 2provided by MGI
Primary source
MGI:MGI:2443098
See related
Ensembl:ENSMUSG00000036110 AllianceGenome:MGI:2443098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NPT3; C730032N17Rik
Summary
Enables urate transmembrane transporter activity. Predicted to be involved in monoatomic anion transport. Located in apical plasma membrane. Orthologous to human SLC17A2 (solute carrier family 17 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 29.3), liver E18 (RPKM 6.3) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Slc17a2 in Genome Data Viewer
Location:
13 A3.1; 13 9.94 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23990924..24009174)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23806941..23825191)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 38 Neighboring gene STARR-positive B cell enhancer ABC_E8516 Neighboring gene predicted gene 11337 Neighboring gene solute carrier family 17 (sodium phosphate), member 3 Neighboring gene solute carrier family 17 (sodium phosphate), member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wide expression of type I Na+-phosphate cotransporter 3 (NPT3/SLC17A2), a membrane potential-driven organic anion transporter. Togawa N, et al. Am J Physiol Cell Physiol, 2015 Jul 15. PMID 25972451
  2. Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation. Goodings C, et al. Stem Cells, 2015 Aug. PMID 25968920, Free PMC Article
  3. Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression. Prince JE, et al. Development, 2013 Jun. PMID 23637329, Free PMC Article
  4. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Boj SF, et al. Cell, 2012 Dec 21. PMID 23260145
  5. The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. Labialle S, et al. EMBO J, 2014 Oct 1. PMID 25124681, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suggest that murine NPT3 is a polyspecific organic anion transporter that is involved in circulation of urate throughout the body.
    Title: Wide expression of type I Na+-phosphate cotransporter 3 (NPT3/SLC17A2), a membrane potential-driven organic anion transporter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC19073

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables urate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in urate transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium-dependent phosphate transport protein 3
Names
Na(+)/PI cotransporter 3
sodium/phosphate cotransporter 3
solute carrier family 17 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377113.1 → NP_001364042.1  sodium-dependent phosphate transport protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL590388
    UniProtKB/Swiss-Prot
    Q5SZA1, Q8VCX8
    Related
    ENSMUSP00000097288.3, ENSMUST00000099697.3
    Conserved Domains (1) summary
    cd17318
    Location:21 → 462
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  2. NM_144836.3 → NP_659085.1  sodium-dependent phosphate transport protein 3 isoform 2

    See identical proteins and their annotated locations for NP_659085.1

    Status: VALIDATED

    Source sequence(s)
    AL590388
    Consensus CDS
    CCDS36620.1
    UniProtKB/Swiss-Prot
    Q5SZA1
    Related
    ENSMUSP00000006786.5, ENSMUST00000006786.11
    Conserved Domains (1) summary
    cd17318
    Location:21 → 434
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23990924..24009174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516646.2 → XP_006516709.1  sodium-dependent phosphate transport protein 3 isoform X1

    Conserved Domains (1) summary
    cd17318
    Location:21 → 464
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  2. XM_006516654.4 → XP_006516717.1  sodium-dependent phosphate transport protein 3 isoform X9

    Conserved Domains (1) summary
    cl28910
    Location:21 → 312
    MFS; Major Facilitator Superfamily

  3. XM_006516649.2 → XP_006516712.1  sodium-dependent phosphate transport protein 3 isoform X3

    Conserved Domains (1) summary
    cd17318
    Location:21 → 435
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  4. XM_006516651.3 → XP_006516714.1  sodium-dependent phosphate transport protein 3 isoform X5

    Conserved Domains (1) summary
    cd17318
    Location:21 → 436
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  5. XM_006516653.4 → XP_006516716.1  sodium-dependent phosphate transport protein 3 isoform X7

    Conserved Domains (1) summary
    cl28910
    Location:21 → 312
    MFS; Major Facilitator Superfamily

  6. XM_036157986.1 → XP_036013879.1  sodium-dependent phosphate transport protein 3 isoform X8

    Conserved Domains (1) summary
    cl28910
    Location:21 → 310
    MFS; Major Facilitator Superfamily

  7. XM_006516648.4 → XP_006516711.1  sodium-dependent phosphate transport protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006516711.1

    UniProtKB/Swiss-Prot
    Q5SZA1, Q8VCX8
    Conserved Domains (1) summary
    cd17318
    Location:21 → 462
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  8. XM_006516650.4 → XP_006516713.1  sodium-dependent phosphate transport protein 3 isoform X4

    Conserved Domains (1) summary
    cd17318
    Location:21 → 433
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

  9. XM_006516652.3 → XP_006516715.1  sodium-dependent phosphate transport protein 3 isoform X6

    See identical proteins and their annotated locations for XP_006516715.1

    UniProtKB/Swiss-Prot
    Q5SZA1
    Conserved Domains (1) summary
    cd17318
    Location:21 → 434
    MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

RNA

  1. XR_003950445.1 RNA Sequence

  2. XR_382067.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SZA1.1 GenPept UniProtKB/Swiss-Prot:Q5SZA1

Gene LinkOut

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